Abstract: Methods for producing megakaryocytes and platelets derived from inducible pluripotent stem cells are provided. Such megakaryocytes or platelets can be genetically modified to comprise a nucleic acid molecule encoding a therapeutic agent. The present disclosure further provides methods and compositions for loading a platelet or a megakaryocyte with a therapeutic agent and for genetically modifying a platelet or a megakaryocyte to express an agent.

Abstract: A valve disk with a disk-like valve body, which has a front with two protruding hubs and a back opposite the front. In order to permit improved flow around the valve disk and reduction of eddies on the outflow side, arc-like recesses running along an inside surface of both hubs are arranged on the front of valve body to deflect the flow around hubs.

Abstract: A control cylinder for a control valve, the control cylinder including a main body having through-openings. To optimize the flow and to reduce cavitation, the through-openings have an inside wall with a curved, oblique or conical profile and/or with edges and/or undercuts.

Abstract: A shut-off valve housing having a through-channel extending inside a main body between an inlet opening and an outlet opening, and a valve seat disposed inside the through-channel. To reduce flow losses, an outflow region of the through-channel immediately downstream of the valve seat on an outflow side has an inwardly curved contour.

Abstract: A valve disk with a disk-like valve body, which has a front with two protruding hubs and a back opposite the front. In order to permit improved flow around the valve disk and reduction of eddies on the outflow side, arc-like recesses running along an inside surface of both hubs are arranged on the front of valve body to deflect the flow around hubs.

Abstract: A cart includes rolling members and a frame connected to the rolling members. The frame provides a ladder-storage space. The frame also is configured to hold a ladder in a substantially vertical position with at least a portion of the ladder in the ladder-storage space. The rolling members form a rolling-member perimeter. The ladder-storage space can be disposed within the rolling-member perimeter in the vertical direction. The frame can include a base having a ladder-support surface for contacting and supporting a ladder. The ladder-support surface can be disposed below tops of at least some of the rolling members.

Abstract: A flip-open floor sign includes a display panel, a first foot, and a second foot. The first foot and second foot are each connected to a lower portion of the display panel by a connecting mechanism. The first foot and second foot are configured to move between a closed position and an open position, and are configured to pivot relative to the display panel.

Abstract: A waste container assembly has a shell with a contiguous shell side wall. The side wall defines an open bottom, an open shell top, and a shell interior defined within the shell side wall. A substantially rigid insert has a closed bottom, an open insert top, and a contiguous insert side wall. The closed bottom and the insert side wall together define an interior for refuse collection. The insert is received substantially within the shell interior with the open insert top accessible through the open shell top. A cover has a top panel, a skirt depending from a perimeter of the top panel, and a refuse opening. The skirt is adapted to overlie a portion of an upper end of the contiguous shell wall when installed.

Abstract: A waste container assembly has a shell with a contiguous shell side wall. The side wall defines an open bottom, an open shell top, and a shell interior defined within the shell side wall. A substantially rigid insert has a closed bottom, an open insert top, and a contiguous insert side wall. The closed bottom and the insert side wall together define an interior for refuse collection. The insert is received substantially within the shell interior with the open insert top accessible through the open shell top. A cover has a top panel, a skirt depending from a perimeter of the top panel, and a refuse opening. The skirt is adapted to overlie a portion of an upper end of the contiguous shell wall when installed.

Abstract: A vehicle clutch control assembly for use with a hydraulic transmission having a fluid valve. A brake pedal and linkage are connectable with the valve for positioning the clutch in the engaged and disengaged positions. A clutch valve lock-out assembly is also connected with the brake pedal to prevent actuation of the clutch valve when the lock-out assembly is selectively operated, and thus the clutch cannot go through the neutral position when the brake is actuated in the normal manner.