Abstract: A magnetic particle suspension system includes a vessel defining a chamber and an opening to the chamber, particles magnetically responsive to a magnetic field disposed in the chamber, and a suspension apparatus for controllably moving the magnetic field along a path having an engagement portion in which the magnetic field effects a magnetic response in the particles, wherein the suspension apparatus includes a motor, an arm movably driven by the motor, and a magnet supported by the arm for movement along the path, wherein the motor rotatably drives the arm about a drive axis so that the magnet travels along a circumaxial path about the drive axis.

Abstract: A membrane-based fluid degassing system is arranged for automated control to a degassing efficiency set point, so that fluid is degassed only as necessary. The control variable may be assigned as the degassing environment, to provide the gas transfer driving force suitable to appropriately degas the fluid. By avoiding unnecessary degassing of the fluid, mobile phase pervaporation through the membrane is minimized.

Abstract: The pressure fluctuations in a fluid degassing system may be diminished by independently controlling the intake phase and the exhaust phase of an evacuation pump. The speed of the pump's drive element may be modulated at least during the intake phase to more closely align with a pressure set point in a degassing module.

Abstract: The pressure fluctuations in a fluid degassing system may be diminished by independently controlling the intake phase and the exhaust phase of an evacuation pump. The speed of the pump's drive element may be modulated at least during the intake phase to more closely align with a pressure set point in a degassing module.

Abstract: A membrane gas-liquid contactor is arranged to define a fluid flow path for contact with a membrane in a manner to improve degassing efficiency. A degassing module housing the membrane is arranged with flow fields for distributing the fluid flow throughout the membrane contact area. The distributed fluid flow may have a uniform membrane contact opportunity.

Abstract: A manifold assembly has a manifold and can be located between a block and a plate, and serve as a stator for a valve or other component. The manifold, block or plate can have a plurality of ports either integral thereto or removably connected thereto, with the ports adapted to receive and sealingly engage with a tube having an inner tube layer, an outer tube layer, a sleeve, a tip portion, and a nut. Each of the nut, sleeve, inner and outer tubing layers, and tip portion have a passageway therethrough, with at least the passageways in the sleeve, tip portion, outer tube layer, and nut adapted to allow the inner tube layer to pass therethrough or extend over the inner layer. The ends of the tip portion and inner layer together can define a substantially flat surface which can form a seal in a flat-bottomed port of the manifold, block, or plate, which can be used in a component in an analytical instrument system, including for example a liquid chromatography system.

Abstract: A multi-dimensional liquid analysis system includes a first dimension system and a second dimension system, wherein outflow from the first dimension system is separated at a flow splitter under controlled conditions. The flow splitter separates the first dimension outflow into first and second split outlet flows, with one of the split outlet flows being metered to a designated flow rate with a flow metering device disposed downstream from the flow splitter. The flow metering device selectively closes or opens an outlet flow path to define a volumetric flow rate along that outlet flow path, so that the other split outlet flow is correspondingly controlled.

Abstract: A membrane-based fluid degassing system is arranged for automated control to a degassing efficiency set point, so that fluid is degassed only as necessary. The control variable may be assigned as the degassing environment, to provide the gas transfer driving force suitable to appropriately degas the fluid. By avoiding unnecessary degassing of the fluid, mobile phase pervaporation through the membrane is minimized.

Abstract: A device which includes a pulse dampener and a degasser or de-bubbler. The device includes a fluid flow path and a fluid chamber located within the device. In addition, the device includes a pulse dampening membrane for dampening pulses in the fluid as it flows through the device. The device also includes a degassing membrane for degassing the fluid as it flows through the device, and/or a de-bubbling membrane for removing gas bubbles from the fluid as it flows through the device. The degassing or de-bubbling membrane can be separate and distinct from the dampening membrane. The de-bubbling membrane can be in addition to or in place of the degassing membrane in some embodiments.

Abstract: Valve with multi-piece stator assembly for use with liquid chromatography or other analytical systems. A separate and removable stator plate is provided with a mounting device to provide a multi-piece stator assembly. The mounting device is adapted on one side to engage and contact the stator plate, and on the other side includes a plurality of ports for fluidic connections which are in fluid communication with fluid passageways in the stator plate. By making the stator face a separate component, the overall costs of the valve can be reduced, different materials can be used for the mounting device and the stator, and the valve can be used for ultra-high pressure applications, including in liquid chromatography and other analytical instrument systems.

Abstract: A membrane gas-liquid contactor is arranged to define a fluid flow path for contact with a membrane in a manner to improve degassing efficiency. A degassing module housing the membrane is arranged with flow fields for distributing the fluid flow throughout the membrane contact area. The distributed fluid flow may have a uniform membrane contact opportunity.

Abstract: A membrane gas-liquid contactor is arranged to define a fluid flow path for contact with a membrane in a manner to improve degassing efficiency. A degassing module housing the membrane is arranged with flow fields for distributing the fluid flow throughout the membrane contact area. The distributed fluid flow may have a uniform membrane contact opportunity.

Abstract: A liquid sampling system includes a liquid sampling valve for transferring a liquid sample from a primary stream to a secondary stream. The liquid sampling valve includes a rotor having a movable shuttle that is in selective fluid communication with the primary stream or the secondary stream. The rotor shuttle passes through a discharge station prior to completion of the valve cycle to discharge contaminants prior to re-exposure to the primary stream.

Abstract: Valve with multi-piece stator assembly for use with liquid chromatography or other analytical systems. A separate and removable stator plate is provided with a mounting device to provide a multi-piece stator assembly. The mounting device is adapted on one side to engage and contact the stator plate, and on the other side includes a plurality of ports for fluidic connections which are in fluid communication with fluid passageways in the stator plate. By making the stator face a separate component, the overall costs of the valve can be reduced, different materials can be used for the mounting device and the stator, and the valve can be used for ultra-high pressure applications, including in liquid chromatography and other analytical instrument systems.

Abstract: A device which includes a pulse dampener and a degasser or de-bubbler. The device includes a fluid flow path and a fluid chamber located within the device. In addition, the device includes a pulse dampening membrane for dampening pulses in the fluid as it flows through the device. The device also includes a degassing membrane for degassing the fluid as it flows through the device, and/or a de-bubbling membrane for removing gas bubbles from the fluid as it flows through the device. The degassing or de-bubbling membrane can be separate and distinct from the dampening membrane. The de-bubbling membrane can be in addition to or in place of the degassing membrane in some embodiments.

Abstract: A manifold assembly has a manifold and can be located between a block and a plate, and serve as a stator for a valve or other component. The manifold, block or plate can have a plurality of ports either integral thereto or removably connected thereto, with the ports adapted to receive and sealingly engage with a tube having an inner tube layer, an outer tube layer, a sleeve, a tip portion, and a nut. Each of the nut, sleeve, inner and outer tubing layers, and tip portion have a passageway therethrough, with at least the passageways in the sleeve, tip portion, outer tube layer, and nut adapted to allow the inner tube layer to pass therethrough or extend over the inner layer. The ends of the tip portion and inner layer together can define a substantially flat surface which can form a seal in a flat-bottomed port of the manifold, block, or plate, which can be used in a component in an analytical instrument system, including for example a liquid chromatography system.

Abstract: A device which includes a pulse dampener and a degasser or de-bubbler. The device includes a fluid flow path and a fluid chamber located within the device. In addition, the device includes a pulse dampening membrane for dampening pulses in the fluid as it flows through the device. The device also includes a degassing membrane for degassing the fluid as it flows through the device, and/or a de-bubbling membrane for removing gas bubbles from the fluid as it flows through the device. The degassing or de-bubbling membrane can be separate and distinct from the dampening membrane. The de-bubbling membrane can be in addition to or in place of the degassing membrane in some embodiments.

Abstract: An elongated fluid degassing apparatus may be employed as a fluid transfer line for fluidly connecting components in a liquid system, while at the same time degassing, or preventing re-gassing of, the fluid. The fluid transfer line degassing apparatus forms a shell and tube degassing arrangement, wherein shell-side fluid flow is facilitated by one or more spacer elements that centrally position a semi-permeable separation membrane in the shell chamber. The degasser may include one or more tubular separation membranes that provide a gas-permeable, liquid-impermeable contact surface to effect the gas-liquid separation of the process fluid.

Abstract: A multi-dimensional liquid analysis system includes a first dimension system and a second dimension system, wherein outflow from the first dimension system is separated at a flow splitter under controlled conditions. The flow splitter separates the first dimension outflow into first and second split outlet flows, with one of the split outlet flows being metered to a designated flow rate with a flow metering device disposed downstream from the flow splitter. The flow metering device selectively closes or opens an outlet flow path to define a volumetric flow rate along that outlet flow path, so that the other split outlet flow is correspondingly controlled.

Abstract: A multi-dimensional liquid analysis system includes a first dimension system and a second dimension system, wherein outflow from the first dimension system is separated at a flow splitter under controlled conditions. The flow splitter separates the first dimension outflow into first and second split outlet flows, with one of the split outlet flows being metered to a designated flow rate with a flow metering device disposed downstream from the flow splitter. The flow metering device selectively closes or opens an outlet flow path to define a volumetric flow rate along that outlet flow path, so that the other split outlet flow is correspondingly controlled.