Patents by Inventor Carl W. Cotman
Carl W. Cotman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230057592Abstract: Use of H3K9me3 modulation for enhancing cognitive function and treating anxiety related disorders is presented. A composition is administered to the subject comprising a therapeutically effective amount of a SUV39H1 inhibitor comprising analogs of ETP69. The therapeutically effective amount is effective in treating cognitive dysfunction in aging and age-related disorders.Type: ApplicationFiled: March 17, 2022Publication date: February 23, 2023Inventors: Carl W. COTMAN, Larry E. OVERMAN, Shikha SNIGDHA
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Patent number: 11311551Abstract: Use of H3K9me3 modulation for enhancing cognitive function and treating anxiety related disorders is presented. A composition is administered to the subject comprising a therapeutically effective amount of a SUV39H1 inhibitor comprising analogs of ETP69. The therapeutically effective amount is effective in treating cognitive dysfunction in aging and age-related disorders.Type: GrantFiled: October 16, 2020Date of Patent: April 26, 2022Assignee: REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Carl W. Cotman, Larry E. Overman, Shikha Snigdha
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Publication number: 20210106590Abstract: Use of H3K9me3 modulation for enhancing cognitive function and treating anxiety related disorders is presented. A composition is administered to the subject comprising a therapeutically effective amount of a SUV39H1 inhibitor comprising analogs of ETP69. The therapeutically effective amount is effective in treating cognitive dysfunction in aging and age-related disorders.Type: ApplicationFiled: October 16, 2020Publication date: April 15, 2021Inventors: Carl W. COTMAN, Larry E. OVERMAN, Shikha SNIGDHA
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Patent number: 10849910Abstract: Use of H3K9me3 modulation for enhancing cognitive function and treating anxiety related disorders is presented. A composition is administered to the subject comprising a therapeutically effective amount of a SUV39H1 inhibitor comprising analogs of ETP69. The therapeutically effective amount is effective in treating cognitive dysfunction in aging and age-related disorders.Type: GrantFiled: March 15, 2019Date of Patent: December 1, 2020Assignee: REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Carl W. Cotman, Larry E. Overman, Shikha Snigdha
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Publication number: 20190209577Abstract: Use of H3K9me3 modulation for enhancing cognitive function and treating anxiety related disorders is presented. A composition is administered to the subject comprising a therapeutically effective amount of a SUV39H1 inhibitor comprising analogs of ETP69. The therapeutically effective amount is effective in treating cognitive dysfunction in aging and age-related disorders.Type: ApplicationFiled: March 15, 2019Publication date: July 11, 2019Inventors: Carl W. COTMAN, Larry E. OVERMAN, Shikha SNIGDHA
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Patent number: 10272093Abstract: Use of H3K9me3 modulation for enhancing cognitive function and treating anxiety related disorders is presented. A composition is administered to the subject comprising a therapeutically effective amount of a SUV39H1 inhibitor comprising analogs of ETP69. The therapeutically effective amount is effective in treating cognitive dysfunction in aging and age-related disorders.Type: GrantFiled: June 3, 2016Date of Patent: April 30, 2019Assignee: Regents of the University of CaliforniaInventors: Carl W. Cotman, Larry E. Overman, Shikha Snigdha
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Publication number: 20180228808Abstract: Use of H3K9me3 modulation for enhancing cognitive function and treating anxiety related disorders is presented. A composition is administered to the subject comprising a therapeutically effective amount of a SUV39H1 inhibitor comprising analogs of ETP69. The therapeutically effective amount is effective in treating cognitive dysfunction in aging and age-related disorders.Type: ApplicationFiled: June 3, 2016Publication date: August 16, 2018Inventors: Carl W. COTMAN, Larry E. OVERMAN, Shikha SNIGDHA
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Patent number: 8687879Abstract: Provides quantitative data about a two or more dimensional image. Classifies and counts number of entities an image contains. Each entity comprises a structure, or some other type of identifiable portion having definable characteristics. The entities located within an image may have different shape, color, texture, etc., but still belong to the same classification. Alternatively, entities comprising a similar color/texture may be classified as one type while entities comprising a different color/texture may be classified as another type. May quantify image data according to set of changing criteria and derive one or more classifications for entities in image. I.e., provides a way for a computer to determine what kind of entities (e.g., entities) are in image and counts total number of entities visually identified in image. Information utilized during a training process may be stored and applied across different images.Type: GrantFiled: October 6, 2011Date of Patent: April 1, 2014Inventors: Carl W. Cotman, Charles F. Chubb, Yoshiyuki Inagaki, Brian Cummings
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Publication number: 20120121169Abstract: Provides quantitative data about a two or more dimensional image. Classifies and counts number of entities an image contains. Each entity comprises a structure, or some other type of identifiable portion having definable characteristics. The entities located within an image may have different shape, color, texture, etc., but still belong to the same classification. Alternatively, entities comprising a similar color/texture may be classified as one type while entities comprising a different color/texture may be classified as another type. May quantify image data according to set of changing criteria and derive one or more classifications for entities in image. I.e., provides a way for a computer to determine what kind of entities (e.g., entities) are in image and counts total number of entities visually identified in image. Information utilized during a training process may be stored and applied across different images.Type: ApplicationFiled: October 6, 2011Publication date: May 17, 2012Inventors: Carl W. Cotman, Charles F. Chubb, Yoshiyuki Inagaki, Brian Cummings
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Publication number: 20080257735Abstract: A multi-compartment microfluidic device for enabling fluidic isolation among interconnected compartments and accomplishing centrifugal positioning and/or patterned substrate positioning of biological specimens. Includes micropatterned substrate coupled with optically transparent housing allowing imaging. Housing includes microfluidic region having entry reservoir for accepting first volume of fluid and additional microfluidic region(s) having a second entry reservoir for accepting second volume of fluid less than first volume of fluid to create hydrostatic pressure. A barrier region that couples the microfluidic region with the second microfluidic region enables biological specimen(s) to extend across the microfluidic, barrier region and second microfluidic region. The barrier region includes embedded microgroove(s) having width and height enabling second volume of fluid to be fluidically isolated from first volume of fluid via hydrostatic pressure maintained via the embedded microgroove(s).Type: ApplicationFiled: September 26, 2005Publication date: October 23, 2008Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Noo Li Jeon, Anne M. Taylor, Carl W. Cotman, David H. Cribbs
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Publication number: 20080107330Abstract: Provides quantitative data about a two or more dimensional image. Classifies and counts number of entities an image contains. Each entity comprises a structure, or some other type of identifiable portion having definable characteristics. The entities located within an image may have different shape, color, texture, etc., but still belong to the same classification. Alternatively, entities comprising a similar color/texture may be classified as one type while entities comprising a different color/texture may be classified as another type. May quantify image data according to set of changing criteria and derive one or more classifications for entities in image. I.e., provides a way for a computer to determine what kind of entities (e.g., entities) are in image and counts total number of entities visually identified in image. Information utilized during a training process may be stored and applied across different images.Type: ApplicationFiled: July 3, 2007Publication date: May 8, 2008Inventors: Carl W. Cotman, Charles F. Chubb, Yoshiyuki Inagaki, Brian Cummings
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Patent number: 7254266Abstract: Provides quantitative data about a two or more dimensional image. Classifies and counts number of entities an image contains. Each entity comprises a structure, or some other type of identifiable portion having definable characteristics. The entities located within an image may have different shape, color, texture, etc., but still belong to the same classification. Alternatively, entities comprising a similar color/texture may be classified as one type while entities comprising a different color/texture may be classified as another type. May quantify image data according to set of changing criteria and derive one or more classifications for entities in image. I.e., provides a way for a computer to determine what kind of entities (e.g., entities) are in image and counts total number of entities visually identified in image. Information utilized during a training process may be stored and applied across different images.Type: GrantFiled: June 23, 2006Date of Patent: August 7, 2007Inventors: Carl W. Cotman, Charles F. Chubb, Yoshiyuki Inagaki, Brian Cummings
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Patent number: 7088854Abstract: One embodiment of the invention provides a process and related apparatus for obtaining quantitative data about a 2-dimensional, 3-dimensional image, or other dimensional image. For example, the invention is capable of classifying and counting the number of entities an image contains. Each entity comprises an entity, structure, or some other type of identifiable portion of the image having definable characteristics. The entities located within an image may have a different shape, color, texture, or other definable characteristic, but still belong to the same classification. In other instances, entities comprising a similar color, and texture may be classified as one type while entities comprising a different color, and texture may be classified as another type. An image may contain multiple entities and each entity may belong to a different class.Type: GrantFiled: April 25, 2002Date of Patent: August 8, 2006Inventors: Carl W. Cotman, Charles F. Chubb, Yoshiyuki Inagaki, Brian Cummings
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Publication number: 20020186882Abstract: One embodiment of the invention provides a process and related apparatus for obtaining quantitative data about a 2-dimensional, 3-dimensional image, or other dimensional image. For example, the invention is capable of classifying and counting the number of entities an image contains. Each entity comprises an entity, structure, or some other type of identifiable portion of the image having definable characteristics. The entities located within an image may have a different shape, color, texture, or other definable characteristic, but still belong to the same classification. In other instances, entities comprising a similar color, and texture may be classified as one type while entities comprising a different color, and texture may be classified as another type. An image may contain multiple entities and each entity may belong to a different class.Type: ApplicationFiled: April 25, 2002Publication date: December 12, 2002Inventors: Carl W. Cotman, Charles F. Chubb, Yoshiyuki Inagaki, Brian Cummings
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Patent number: 5942537Abstract: A method of inhibiting the transport of a neurotransmitter away from the synapse comprising contacting a neurotransmitter transporter with a compound having the structure ##STR1## wherein ##STR2## or CONHR.sup.3 in any combination and and wherein R.sup.2 =OR.sup.3, NR.sup.3.sub.2, alkyl, or substituted alkyl and R.sup.3 =alkyl or substituted alkyl.Type: GrantFiled: August 9, 1993Date of Patent: August 24, 1999Assignee: The Regents of the University of CaliforniaInventors: A. Richard Chamberlin, Richard J. Bridges, Carl W. Cotman, Mark S. Stanley
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Patent number: 5622981Abstract: A method of treating a mammal with a neurodegenerative disease which is caused at least in part by the neurotoxic effects of the .beta.-amyloid protein. This method constitutes administering a metabotropic receptor agonist to such a mammal. In particular, the agonist trans-ACPD or 1S,3R-ACPD can be administered intravenously to treat a mammal with Alzheimer's disease.Type: GrantFiled: April 7, 1995Date of Patent: April 22, 1997Assignee: Cortex Pharmaceuticals, Inc.Inventors: David D. Eveleth, Judith A. Kelleher, Carl W. Cotman
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Patent number: 5135956Abstract: A method for treating or preventing neuronal injury in a mammal, comprising the step of administering in vivo a therapeutically effective amount of a long-chain fatty alcohol having from about 23 to about 29 carbon atoms or prodrug esters thereof. Also disclosed are pharmacological compositions containing from 0.01 mg/kg to about 20 mg/kg of the fatty alcohol. The method and compositions are useful in: treating traumatic injury, chemical injury and injury due to disease; promoting and accelerating recovery of behavioral function after such injury; preventing neuronal injury or death; improving training and memory functions; and protecting neurons against injury.Type: GrantFiled: October 13, 1989Date of Patent: August 4, 1992Assignee: The Regents of the University of CaliforniaInventors: Jacques Borg, Carl W. Cotman, J. Patrick Kesslak