Patents by Inventor Carl WALKEY

Carl WALKEY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPY USING AN IL-2 RECEPTOR AGONIST AND AN IMMUNE CHECKPOINT INHIBITOR
    Publication number: 20230331858
    Abstract: The present disclosure is directed to, inter alia, methods for modulating an immune response in a subject in need thereof using an IL-2 receptor agonist in combination with an immune checkpoint inhibitor.
    Type: Application
    Filed: November 9, 2020
    Publication date: October 19, 2023
    Inventors: Carl WALKEY, Jonathan DRACHMAN, Umut ULGE, Daniel Adriano SILVA MANZANO
  • METHODS OF ADMINISTRATION OF IL-2 RECEPTOR AGONISTS
    Publication number: 20220370563
    Abstract: The present invention provides, inter alia, treatment regimens for administration of an IL-2 receptor agonist. The present invention is directed to, inter alia, methods for modulating an immune response in a subject in need thereof with an IL-2 receptor agonist. In some aspects, the immune response is an anti-cancer immune response.
    Type: Application
    Filed: October 22, 2020
    Publication date: November 24, 2022
    Inventors: Carl WALKEY, Jonathan DRACHMAN, Umut ULGE, Daniel Adriano SILVA MANZANO
  • De Novo Design of Potent and Selective Interleukin Mimetics
    Publication number: 20220235110
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ?c heterodimer (IL-2R?c), IL-4 receptor ?c heterodimer (IL-4R?c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Application
    Filed: March 18, 2022
    Publication date: July 28, 2022
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl WALKEY
  • DE NOVO DESIGN OF TUNABLE PH-DRIVEN CONFORMATIONAL SWITCHES
    Publication number: 20220144895
    Abstract: Disclosed herein are polypeptides or polypeptide oligomers, including a buried hydrogen bond network that includes at least (1, 2, 3, 4, 5, 6, 7, 8, or 9) pH sensitive amino acids located (i) at an intra-chain interface between different: structural elements in one polypeptide, or (it) at an inter-chain interface between structural elements present in different chains of a polypeptide oligomer, wherein the polypeptide or polypeptide oligomer is stable above a given pH, and wherein the polypeptide or polypeptide oligomer undergoes a conformational transition when subjected to a pH at or below the given pH.
    Type: Application
    Filed: April 20, 2020
    Publication date: May 12, 2022
    Inventors: Scott BOYKEN, David BAKER, Zibo CHEN, Alfredo Quijano RUBIO, Neil P. KING, Jason C. KLIMA, Carl WALKEY
  • De Novo Design of Potent and Selective Interleukin Mimetics
    Publication number: 20200317744
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??c heterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Application
    Filed: June 23, 2020
    Publication date: October 8, 2020
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl WALKEY
  • De Novo Design of Potent and Selective Interleukin Mimetics
    Publication number: 20200002398
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??cheterodimer (IL-2R??c), IL-4 receptor ??cheterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Application
    Filed: September 16, 2019
    Publication date: January 2, 2020
    Inventors: Daniel Adriano SILVA MANZANO, Shawn YU, Umut ULGE, David BAKER, Kenan Christopher GARCIA, Jamie SPANGLER, Carl WALKEY, Alfredo QUIJANO RUBIO