Abstract: According to an aspect of the disclosure, a method is provided comprising receiving sensor data from a sensor of a vehicle, such as an autonomous vehicle, and determining, based at least in part on the sensor data, a subset of motion options from a predetermined set of motions options associated with controlling the vehicle. A representation of the subset of motion options is transmitted to a remote system. A first motion option of the subset of motion options is received from the remote system, and the vehicle is controlled based at least in part on the first motion option.

Abstract: Provided herein, inter alia, are methods and compounds for targeted autophagy.

Abstract: Provided are media and methods for establishing and maintaining mammalian early embryo-like cells. The culture media can be used to culture mammalian pluripotent stem cells (PSCs), are chemically defined, and comprise basal media for culturing stem cells supplemented with a S-adenosylhomocysteine hydrolase (SAH)/Polycomb repressive complexes (PRC)/EZH2 inhibitor and a histone deacetylase (HDAC) inhibitor. With the culture media thereof, primate (human and non-human) PSCs can be converted to preimplantation ICM-like cells (ICLCs) or 8-cell embryo-like cells (8CLCs).

Abstract: Provided are media and methods for establishing and maintaining mammalian early embryo-like cells. The culture media can be used to culture mammalian pluripotent stem cells (PSCs), which is chemically defined and comprises basal media for culturing stem cells supplemented with a S-adenosylhomocysteine hydrolase (SAH)/Polycomb repressive complexes (PRC)/EZH2 inhibitor, a histone deacetylase (HDAC) inhibitor and a WNT/?-catenin signaling/tankyrase inhibitor. With the culture media, primate (human and non-human) PSCs can be converted to preimplantation ICM-like cells (ICLCs) or 8-cell embryo-like cells (8CLCs).

Abstract: Provided herein, inter alia, are methods and compounds for targeted autophagy.

Abstract: The invention relates to methods of generating hepatic cells by overexpressing combinations of transcription factors, in particular for use in cellular reprogramming methods.

Abstract: The invention relates to methods of generating hepatic cells by overexpressing combinations of transcription factors, in particular for use in cellular reprogramming methods.

Abstract: The invention relates to methods of generating hepatic cells by overexpressing combinations of transcription factors, in particular for use in cellular reprogramming methods.

Abstract: Provided herein, inter alia, are methods and compounds for targeted autophagy.

Abstract: A high performance capability assessment model helps a revenue industry agency meet the challenges of the global marketplace. As a result, the revenue industry can achieve the clarity, consistency, and well-defined execution of core processes that reduce inefficiencies and waste that result from unnecessary process complexity and exceptions. In addition, the high performance capability assessment model helps the revenue industry agency to identify specific areas in which improvements may be made and understand how to make the improvements, and establishes levels of capability along the way to reaching an ultimate capability goal.

Abstract: A system for receiving and processing data includes a data processing and verification component that accepts data from a client in an electronic format and identifies therefrom data elements that can be directly verified. A risk assessment component receives data elements that have not been identified as directly verifiable and assesses a risk that the data elements are incomplete or incorrect. The risk assessment component generates risk assessment data. A decision support component receives the risk assessment data from the risk assessment component and selects appropriate actions for subsequent processing of the client data according to the assessment of risk contained in the risk assessment data.

Abstract: A toy doll may include a body supported by a skeletal structure including one or more joint assemblies. A joint assembly may include a pivot block further including a pivot stop, and a joint member rotatably coupled to the pivot block, the joint member further including a stop protrusion configured to engage the pivot stop upon rotation of the joint member in a predetermined direction, wherein engagement of the pivot stop prevents further rotation of the joint member in a predetermined direction, wherein the joint member is moveable through a predetermined range of motion transverse to the plane of rotation of the joint member, and wherein movement of the joint member transverse to the plane of rotation allows the stop protrusion to bypass the pivot stop.

Abstract: The present invention relates to a wrinkle reducing composition for use on fabrics, particularly clothing. The composition comprises a wrinkle reducing active, which is made up of an effective amount of silicone and an effective amount of film-forming polymer, and a liquid carrier. The composition is substantially free of starch, modified starch, and mixtures thereof, and results a Loss Modulus Difference of greater than about 3.3.times.10.sup.7 Pascal on fabric. The composition can be incorporated into a spray dispenser that can create an article of manufacture which facilitates treatment of the fabric with the wrinkle reducing composition. The wrinkle reducing actives in the composition can be determined through Dynamic Mechanical Analysis using a 100% cotton broadcloth swatch and a fixed volume of a sample of wrinkle reducing active.