Patents by Inventor Carla Christina Schrier

Carla Christina Schrier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10954491
    Abstract: The present invention relates to a novel porcine pestivirus, to proteins of the virus and to vaccines based upon the virus and proteins thereof. The invention also relates to DNA fragments comprising a gene of the virus and to DNA vaccines based upon genes of the virus. Furthermore the invention relates to antibodies that are reactive with the novel virus and to diagnostic tests for the detection of the virus or antibodies against the virus.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: March 23, 2021
    Assignee: Intervet Inc.
    Inventors: Ad de Groof, Lars Guelen, Carla Christina Schrier, Martin Deijs, Cornelia Maria van der Hoek
  • Patent number: 10512685
    Abstract: The present invention relates to a vaccine comprising Open Reading Frame 2 (ORF2) protein of Swine Hepatitis E virus (HEV) and a pharmaceutically acceptable carrier, for use in the protection of anti-HEV MDA-positive piglets against HEV fecal shedding.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: December 24, 2019
    Assignee: Intervet Inc.
    Inventors: Paul Vermeij, Ad Groof De, Carla Christina Schrier, Wannes Vogels
  • Patent number: 10398773
    Abstract: The present invention relates to a novel porcine parvovirus, to proteins of the virus and to vaccines based upon the virus and proteins thereof. The invention also relates to DNA fragments comprising a gene of the virus and to DNA vaccines based upon genes of the virus. Further the invention relates to antibodies that are reactive with the novel virus and to diagnostic tests for the detection of the virus or antibodies against the virus.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: September 3, 2019
    Assignee: Intervet Inc.
    Inventors: Lars Guelen, Ad de Groof, Carla Christina Schrier, Martin Deijs, Cornelia Maria Hoek Van Der
  • Publication number: 20190151442
    Abstract: The present invention relates to a vaccine comprising Open Reading Frame 2 (ORF2) protein of Swine Hepatitis E virus (HEV) and a pharmaceutically acceptable carrier, for use in the protection of anti-HEV MDA-positive piglets against HEV fecal shedding.
    Type: Application
    Filed: May 24, 2017
    Publication date: May 23, 2019
    Applicant: Intervet Inc.
    Inventors: Paul Vermeij, Ad Groof De, Carla Christina Schrier, Wannes Vogels
  • Patent number: 10166282
    Abstract: The present invention relates to immortalized porcine alveolar macrophages (PAMs), to cell cultures comprising such PAMs, to methods for the immortalization of PAMs, to methods of replicating PRRS virus on immortalized PAMs and to methods for the preparation of vaccines comprising PRRSV.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: January 1, 2019
    Assignee: Intervet Inc.
    Inventors: Jaap Kool, Carla Christina Schrier
  • Publication number: 20180161417
    Abstract: The present invention relates to immortalized porcine alveolar macrophages (PAMs), to cell cultures comprising such PAMs, to methods for the immortalization of PAMs, to methods of replicating PRRS virus on immortalised PAMs and to methods for the preparation of vaccines comprising PRRSV.
    Type: Application
    Filed: December 8, 2017
    Publication date: June 14, 2018
    Applicant: Intervet Inc.
    Inventors: Jaap Kool, Carla Christina Schrier
  • Patent number: 9872896
    Abstract: The present invention relates to immortalized porcine alveolar macrophages (PAMs), to cell cultures comprising such PAMs, to methods for the immortalization of PAMs, to methods of replicating PRRS virus on immortalized PAMs and to methods for the preparation of vaccines comprising PRRSV.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: January 23, 2018
    Assignee: Intervet Inc.
    Inventors: Jaap Kool, Carla Christina Schrier
  • Publication number: 20170342387
    Abstract: The present invention relates to a novel porcine pestivirus, to proteins of the virus and to vaccines based upon the virus and proteins thereof. The invention also relates to DNA fragments comprising a gene of the virus and to DNA vaccines based upon genes of the virus. Furthermore the invention relates to antibodies that are reactive with the novel virus and to diagnostic tests for the detection of the virus or antibodies against the virus.
    Type: Application
    Filed: December 18, 2015
    Publication date: November 30, 2017
    Applicant: Intervet Inc.
    Inventors: Ad de Groof, Lars Guelen, Carla Christina Schrier, Martin Deijs, Cornelia Maria van der Hoek
  • Patent number: 9757449
    Abstract: The addition of an oligodeoxynucleotide that is an avian TLR21 agonist, to an avian Herpesvirus vector vaccine, provides an acceleration of the immune response against the antigen that is expressed and delivered by the Herpesvirus vector.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: September 12, 2017
    Assignee: Intervet Inc.
    Inventors: Carla Christina Schrier, Wilhelmus Gerardus Johannes Degen
  • Patent number: 9597390
    Abstract: The present invention relates to Infectious bronchitis virus (IBV) spike protein or a fragment thereof comprising a receptor-binding domain, wherein said spike protein or said fragment thereof is C-terminally fused to a trimerisation or tetramerisation domain. Such proteins form trimer or tetramer structures and as such they mimic the natural context of the spike protein. The present invention further relates to subunit vaccines comprising such a protein, to DNA molecules encoding such proteins, to plasmids comprising such DNA molecules, to avian live recombinant carrier viruses (LRCV's) comprising such DNA molecules or plasmids, to vaccines comprising such DNA molecules, plasmids and LRCV's and to combination vaccines comprising an IBV spike protein, DNA molecules, plasmids or LRCV's encoding such a protein, and another IBV vaccine capable of inducing protection against another IBV serotype and/or a vaccine capable of inducing protection against another avian pathogen.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: March 21, 2017
    Assignees: Utrech University, Intervet Inc.
    Inventors: Hélène Verheije, Carla Christina Schrier
  • Publication number: 20170056492
    Abstract: The present invention relates to a novel porcine parvovirus, to proteins of the virus and to vaccines based upon the virus and proteins thereof. The invention also relates to DNA fragments comprising a gene of the virus and to DNA vaccines based upon genes of the virus. Further the invention relates to antibodies that are reactive with the novel virus and to diagnostic tests for the detection of the virus or antibodies against the virus.
    Type: Application
    Filed: April 16, 2015
    Publication date: March 2, 2017
    Applicant: Intervet Inc.
    Inventors: Lars Guelen, Ad Groof, Carla Christina Schrier, Martin Deijs, Cornelia Maria Hoek Van Der
  • Publication number: 20160303220
    Abstract: The present invention relates to immortalized porcine alveolar macrophages (PAMs), to cell cultures comprising such PAMs, to methods for the immortalization of PAMs, to methods of replicating PRRS virus on immortalised PAMs and to methods for the preparation of vaccines comprising PRRSV.
    Type: Application
    Filed: December 11, 2014
    Publication date: October 20, 2016
    Applicant: Intervet Inc.
    Inventors: Jaap Kool, Carla Christina Schrier
  • Patent number: 9364531
    Abstract: The present invention relates to immunostimulatory oligodeoxynucleotides, vectors and vaccines comprising such oligodeoxynucleotides, to their use as a medicament, to their use in preventing or combating infectious disease, to methods for the detection of such oligodeoxynucleotides and to cells to be used in these method.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: June 14, 2016
    Assignee: Intervet Inc.
    Inventors: Carla Christina Schrier, Thomas Simon Ilg
  • Publication number: 20160158347
    Abstract: The addition of an oligodeoxynucleotide that is an avian TLR21 agonist, to an avian Herpesvirus vector vaccine, provides an acceleration of the immune response against the antigen that is expressed and delivered by the Herpesvirus vector.
    Type: Application
    Filed: July 25, 2014
    Publication date: June 9, 2016
    Applicant: Intervet Inc.
    Inventors: Carla Christina Schrier, Wilhelmus Gerardus Johannes Degen
  • Patent number: 9359602
    Abstract: The present invention relates to immunostimulatory oligodeoxynucleotides, vectors and vaccines comprising such oligodeoxynucleotides, to their use as a medicament, to their use in preventing or combating infectious disease, to methods for the detection of such oligodeoxynucleotides and to cells to be used in these methods.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: June 7, 2016
    Assignee: Intervet Inc.
    Inventors: Carla Christina Schrier, Simon Ilg
  • Publication number: 20160136197
    Abstract: The present invention relates to pharmaceutical compositions comprising an immunostimulatory amount of at least two immunopotentiators, wherein a first immunopotentiator is a non-methylated cytidyl guanosyl oligodeoxynucleotide (CpG ODN) and a second immunopotentiator is 3?,5?-cyclic diguanylic acid (c-di-GMP), and a pharmaceutically acceptable carrier. The invention also relates to the use of such pharmaceutical compositions for the induction of an immune response against tumor-specific antigens. Also the invention relates to their use in in situ tumor-destruction therapy and to such pharmaceutical compositions for use in the treatment of a mammal suffering from cancer.
    Type: Application
    Filed: June 13, 2014
    Publication date: May 19, 2016
    Inventors: Carla Christina Schrier, Martijn BROK DEN, Gosse Adema
  • Patent number: 9315814
    Abstract: The present invention relates to immunostimulatory oligodeoxynucleotides, vectors and vaccines comprising such oligodeoxynucleotides, to their use as a medicament, to their use in preventing or combating infectious disease and to methods for the detection of such oligodeoxynucleotides.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: April 19, 2016
    Assignee: Intervet Inc.
    Inventors: Carla Christina Schrier, Simon Ilg
  • Patent number: 9284532
    Abstract: The present invention relates to mammalian cells capable of propagating Arterivirus, to such cells infected with Arterivirus, to cell cultures comprising such cells and to methods for the propagation of an Arterivirus in such cells.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: March 15, 2016
    Assignee: Intervet Inc.
    Inventors: Lars Guelen, Carla Christina Schrier
  • Patent number: 9198963
    Abstract: The present invention pertains to the use of a non-live carbohydrate containing composition, the carbohydrate being also found in live Lawsonia intracellularis cells in association with the outer cell membrane of these cells, for the manufacture of a vaccine for protection against an infection with Lawsonia intracellularis, the vaccine being in a form suitable for systemic administration.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: December 1, 2015
    Assignee: Intervet International B.V.
    Inventors: Antonius Arnoldus Christiaan Jacobs, Paul Vermeij, Ruud Philip Antoon Maria Segers, Carla Christina Schrier
  • Patent number: 9084768
    Abstract: The present invention pertains to a vaccine comprising in combination non-live antigens of Lawsonia intracellularis, of Mycoplasma hyopneumniae and Porcine circo virus, and a pharmaceutically acceptable carrier. The invention also pertains to a kit comprising a first container having contained therein non-live antigens of Lawsonia intracellularis, one or more other containers having contained therein Mycoplasma hyopneumoniae and Porcine circo virus antigens and instructions for mixing the antigens of Lawsonia intracellularis, Mycoplasma hyopneumoniae, and Porcine circo virus to formulate one combination vaccine suitable for systemic vaccination.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: July 21, 2015
    Assignee: Intervet International B.V.
    Inventors: Antonius Arnoldus Christiaan Jacobs, Paul Vermeij, Ruud Philip Antoon Maria Segers, Carla Christina Schrier