Abstract: The present disclosure relates to cleavable carriers and cleavable carrier-linked cytokine prodrugs wherein the cleavable carrier is an engineered Fc domain comprising at least one tumor-associated protease cleavage site. Upon cleavage at the cleavage site of the carrier Fc domain, the cytokine is released from a masking moiety. The platform provides enzymatically induced prodrug activation. The present disclosure further provides pharmaceutical compositions comprising said cleavable carrier-linked cytokine prodrugs, their use as a medication as well as methods of treatment of diseases and administration.

Abstract: The invention relates generally to a system and methods by which physical and digital objects co-exist and can be interacted with in real time. More specifically, the system may facilitate outputting interactive content associated with one or more components of a rubber finishing line, such as a baler machine. The system may include a wearable device—such as a hat or helmet—having a plurality of sensors for receiving spatial telemetry data. Based on the data received, the system may identify one or more physical objects and generate content including one or more virtual objects that may be output to a user via a display of the wearable device. Advantageously, the system may facilitate training a user to operate a component of the rubber finishing line or assisting a user with maintaining or repairing a component of the rubber finishing line.

Abstract: A gas turbine engine including: a fan assembly comprising a fan; and a turbomachine drivingly coupled to the fan and including a compressor section, a combustion section, and a turbine section arranged in serial flow order and defining in part a working gas flowpath, the gas turbine engine defining a bypass passage over the turbomachine; the turbomachine further including a heat exchanger and defining an annular cooling passage extending between an inlet and an outlet, the inlet in airflow communication with the working gas flowpath at a location upstream of the compressor section and the outlet in airflow communication with the bypass passage, the heat exchanger in thermal communication with an airflow through the cooling passage.

Abstract: A method for quality inspection of laser material processing includes performing laser material processing on a workpiece and generating, by a sensor, raw image data of secondary emissions during the laser material processing of the workpiece. The method also includes determining a quality of the laser material processing by analyzing the raw image data of the secondary emissions.

Abstract: A semiconductor wafer processing method, having: ablating a back side of a semiconductor wafer with a laser ablation process; and etching the back side of the semiconductor wafer with an etching process; wherein the laser ablation process forms a pattern in the back side of the semiconductor wafer; wherein the etching process preserves the pattern in the back side of the semiconductor wafer.

Abstract: A laser system includes a controller, a laser source, a laser scanner, and a laser containment apparatus. The laser containment apparatus includes a mounting structure for the laser scanner, a shroud assembly coupled to the mounting structure, and a seal interface coupled to the shroud assembly at an opposite end from the laser scanner. The shroud assembly surrounds a working volume of the laser scanner and includes a vacuum port connected to a vacuum source and a purge port that guides purge gas from a purge gas source toward the laser scanner. A distal end of the seal interface is formed of a pliable material that compresses to seal the shroud assembly to a target surface of a workpiece upon establishment of a negative pressure differential between a vacuum pressure inside the shroud assembly and ambient atmospheric pressure.

Abstract: A detachable saddle bag pet carrier is disclosed. The carrier comprises a box-like container provided with an upper portion that forms part of the container top. The container includes a plurality of vent openings for circulating air flow inside the carrier. The carrier further comprises a lid hinged to the upper portion of the container. The lid includes one or more air vents that could be adjusted from wide open position to fully closed position. The upper portion comprises a skylight mounted on the lid through which a pet could see the outside environment. The carrier is further provided with a removable foam backed carpet placed underneath the container for the pet. The carrier is mounted on the vehicle using a frame assembly to hold the carrier to the vehicle, thereby a user carries the pet within the carrier.

Abstract: A method for quality inspection of laser material processing includes performing laser material processing on a workpiece and generating, by a sensor, raw image data of secondary emissions during the laser material processing of the workpiece. The method also includes determining a quality of the laser material processing by analyzing the raw image data of the secondary emissions.

Abstract: Improved balers may include a traveling chute that may reduce wear and tear and maintenance, and/or improve efficiency by reducing downtime. The traveling chute may include moving guides that include channels that engage tongues of stationary guide rails disposed on a baler. For example, the channels may be substantially rectangular channels that run the length of the moving guide. Similarly, the stationary guides may include substantially rectangular tongues and the moving guides may slide across the tongues and upper surfaces of the stationary guides as the traveling chute moves between various positions. The moving guides may include polyoxymethylene inserts in which the channels may be provided. The moving guides and stationary guides may be provided as a kit for attachment to various baling apparatuses. Additional features and components also are described.

Abstract: A storage control system to provide file-level storage and block-level storage services. The storage control system has a computer system including a second I/O unit configured to receive block-level storage related requests, a processor unit, a first memory unit, and a storage unit; and a programmable logic device including a first I/O unit configured to receive file-level storage related requests, an interface unit configured to communicate with the computer system, one or more programmable hardware-implemented processing units and for processing of file-level storage related requests, and a second memory unit.

Abstract: A squat toilet seat that positions users in a squatting position when sitting on the toilet so that the user's torso and legs form a 35-38° angle. This straightens the colon, relaxing the puborecatlis muscles to ease the strain of having a bowel movement. The toilet seat is thicker in the front than in the back, creating a sloped surface that in turn creates the angle from the user's torso to legs. The toilet seat has left and right attachment parts that are attachable to both rounded and elongated toilet bowl bodies.

Abstract: Embodiments for a packaged semiconductor device and methods of making are provided herein, where a packaged semiconductor device includes a package body having a recess in which a pressure sensor is located; a polymeric gel within the recess that vertically and laterally surrounds the pressure sensor; and a media shield including at least one metal layer on a top surface of the polymeric gel, wherein the media shield and the polymeric gel are sufficiently flexible to transmit pressure to the pressure sensor.

Abstract: A bailing apparatus may include a multi-component bolster assemblies that may ease installation and removal, reduce wear and tear and maintenance, and/or improve baling efficiency by reducing material waste, imperfections, and/or contamination. The bolster assemblies may include a plurality of coupling portions that engage a hydraulic rod and may enable the bolster assembly to self-center within a press chamber during normal baling operations. The bolster assemblies also may include an island portion that may be attached to the coupling portions and to a bolster cap, and the latter may be attached using retainer bolts having substantially planar heads that may define lips that run about frustums. The bolts may substantially planar head may reduce irregularities in the bale and the lips may prevent material seepage into the bolster assemblies.

Abstract: Embodiments for a packaged semiconductor device and methods of making are provided herein, where a packaged semiconductor device includes a package body having a recess in which a pressure sensor is located; a polymeric gel within the recess that vertically and laterally surrounds the pressure sensor; and a media shield including at least one metal layer on a top surface of the polymeric gel, wherein the media shield and the polymeric gel are sufficiently flexible to transmit pressure to the pressure sensor.

Abstract: Improved balers may include a traveling chute that may reduce wear and tear and maintenance, and/or improve efficiency by reducing downtime. The traveling chute may include moving guides that include channels that engage tongues of stationary guide rails disposed on a baler. For example, the channels may be substantially rectangular channels that run the length of the moving guide. Similarly, the stationary guides may include substantially rectangular tongues and the moving guides may slide across the tongues and upper surfaces of the stationary guides as the traveling chute moves between various positions. The moving guides may include polyoxymethylene inserts in which the channels may be provided. The moving guides and stationary guides may be provided as a kit for attachment to various baling apparatuses. Additional features and components also are described.

Abstract: A detachable saddle bag pet carrier is disclosed. The carrier comprises a box-like container provided with an upper portion that forms part of the container top. The container includes a plurality of vent openings for circulating air flow inside the carrier. The carrier further comprises a lid hinged to the upper portion of the container. The lid includes one or more air vents that could be adjusted from wide open position to fully closed position. The upper portion comprises a skylight mounted on the lid through which a pet could see the outside environment. The carrier is further provided with a removable foam backed carpet placed underneath the container for the pet. The carrier is mounted on the vehicle using a frame assembly to hold the carrier to the vehicle, thereby a user carries the pet within the carrier.

Abstract: Improved bales may be formed using methods that include using baling equipment with an air blasting crumb chute that may reduce wear and tear and maintenance, and/or improve efficiency by reducing material waste, imperfections, and/or contamination. The crumb chute may include an air inlet and a plurality of apertures in fluid communication with the air inlet. Air may be provided through the apertures to prevent crumbles from accumulating on the baling assembly as they fall through the chute to the press chamber and/or to blast already accumulated residual crumbles from components of the baling assembly, such as a traveling chute, and into the press chamber. The crumb chute may include a polyoxymethylene insert in which the air inlet and apertures are provided. The crumb chute may be provided as a kit for attachment to various baling apparatuses. Additional features and components also are described.

Abstract: A bailing apparatus may include a multi-component bolster assemblies that may ease installation and removal, reduce wear and tear and maintenance, and/or improve baling efficiency by reducing material waste, imperfections, and/or contamination. The bolster assemblies may include a plurality of coupling portions that engage a hydraulic rod and may enable the bolster assembly to self-center within a press chamber during normal baling operations. The bolster assemblies also may include an island portion that may be attached to the coupling portions and to a bolster cap, and the latter may be attached using retainer bolts having substantially planar heads that may define lips that run about frustums. The bolts may substantially planar head may reduce irregularities in the bale and the lips may prevent material seepage into the bolster assemblies.

Abstract: Methods for forming improved bales may include using baling equipment with multi-component bolster assemblies that may ease installation and removal, reduce wear and tear and maintenance, and/or improve efficiency by reducing material waste, imperfections, and/or contamination. The bolster assemblies may include a plurality of coupling portions that engage a hydraulic rod and may enable the bolster assembly to self-center within a press chamber during normal baling operations. The bolster assemblies also may include an island portion that may be attached to the coupling portions and to a bolster cap, and the latter may be attached using retainer bolts having substantially planar heads that may define lips that run about frustums. The bolts may substantially planar head may reduce irregularities in the bale and the lips may prevent material seepage into the bolster assemblies.

Abstract: A semiconductor device includes a lead frame site including a die attach region and corrugated metal leads around the die attach region. Each of the corrugated metal leads includes two or more corrugations. Each of the two or more corrugations includes a first flat horizontal portion, a first vertical portion with a first end directly adjacent and connected to a first end of the first flat horizontal portion, a second flat horizontal portion with a first end directly adjacent and connected to a second end of the first vertical portion, and a second vertical portion with a first end directly adjacent and connected to a second end of the second flat horizontal portion. The first flat horizontal portion is in a different plane than the second flat horizontal portion.