Patents by Inventor Carleton Proctor Goold

Carleton Proctor Goold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR SELECTIVE PROTEIN DEGRADATION
    Publication number: 20240384007
    Abstract: The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.
    Type: Application
    Filed: April 8, 2024
    Publication date: November 21, 2024
    Inventors: James E. Bradner, Andrei Golosov, Carleton Proctor Goold, Carla Patricia Pinto Guimaraes, Marc Horst Peter Hild, Gregory Motz, Nathan Thomas Ross, Jonathan M. Solomon, Rohan Eric John Beckwith, Seth Carbonneau
  • Compositions and methods for selective protein degradation
    Patent number: 11999802
    Abstract: The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: June 4, 2024
    Assignee: Novartis AG
    Inventors: James E. Bradner, Andrei Golosov, Carleton Proctor Goold, Carla Patricia Pinto Guimaraes, Marc Horst Peter Hild, Gregory Motz, Nathan Thomas Ross, Jonathan M. Solomon, Rohan Eric John Beckwith, Seth Carbonneau
  • VECTORS COMPRISING STUFFER POLYNUCLEOTIDE SEQUENCES
    Publication number: 20240093189
    Abstract: The present disclosure provides vector stuffer polynucleotides and compositions thereof, including expression constructs and vectors, such as viral vectors and methods of delivering a therapeutic agent (e.g., inhibitory nucleic acid) to a mammal or treating a disease.
    Type: Application
    Filed: February 4, 2022
    Publication date: March 21, 2024
    Inventors: Carleton Proctor GOOLD, Robert R. GRAHAM, Peter JANKI, Ronald CHEN, Eric GREEN
  • COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES
    Publication number: 20230287409
    Abstract: The invention relates to inhibitory nucleic acids targeting the ataxin-2 gene (ATXN2), and expression cassettes and vectors comprising the same. Also provided herein are methods of treating neurodegenerative diseases, e.g., Amyotrophic Lateral Sclerosis and Spinocerebellar Ataxia-2.
    Type: Application
    Filed: February 5, 2021
    Publication date: September 14, 2023
    Inventors: Carleton Proctor GOOLD, Ronald CHEN, Peter JANKI, Eric GREEN
  • COMPOSITIONS AND METHODS FOR SELECTIVE PROTEIN DEGRADATION
    Publication number: 20200339704
    Abstract: The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.
    Type: Application
    Filed: October 18, 2018
    Publication date: October 29, 2020
    Inventors: James E. Bradner, Andrei Golosov, Carleton Proctor Goold, Carla Patricia Pinto Guimaraes, Marc Horst Peter Hild, Gregory Motz, Nathan Thomas Ross, Jonathan M. Solomon, Rohan Eric John Beckwith, Seth Carbonneau