Patents by Inventor Carlo Battistini
Carlo Battistini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8399668Abstract: The present invention relates to a process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamides and to the useful intermediate compounds of such process. 5-(2-Amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamides are described and claimed in WO2007110344, which also discloses processes for their preparation. These compounds can be advantageously prepared through a process which allows to obtain the desired products in high yields and purity and with a limited number of steps. The synthesis is starting from a cyano pyrrole derivative, and is characterized from the final hydrolysis of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carbonitrile. The compounds prepared according to the process of the present invention are endowed with protein kinase inhibiting activity and, more particularly, Cdc7 or Cdc7/Cdks inhibiting activity. The compounds are therefore useful in the treatment of a variety of cancers, cell proliferative disorders and diseases associated with protein kinases.Type: GrantFiled: April 30, 2009Date of Patent: March 19, 2013Assignee: Nerviano Medical Sciences S. R. L.Inventors: Matteo D'Anello, Carlo Battistini, Maria Gioia Fornaretto, Ermes Vanotti
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Publication number: 20110040090Abstract: The present invention relates to a process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamides and to the useful intermediate compounds of such process. 5-(2-Amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamides are described and claimed in W02007110344, which also discloses processes for their preparation. These compounds can be advantageously prepared through a process which allows to obtain the desired products in high yields and purity and with a limited number of steps. The synthesis is starting from a cyano pyrrole derivative, and is characterized from the final hydrolysis of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carbonitrile. The compounds prepared according to the process of the present invention are endowed with protein kinase inhibiting activity and, more particularly, Cdc7 or Cdc7/Cdks inhibiting activity. The compounds are therefore useful in the treatment of a variety of cancers, cell proliferative disorders and diseases associated with protein kinases.Type: ApplicationFiled: April 30, 2009Publication date: February 17, 2011Applicant: Nerviano Medical Sciences S.r.l.Inventors: Matteo D'Anello, Carlo Battistini, Maria Gioia Fornaretto, Ermes Vanotti
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Publication number: 20040142993Abstract: The present invention provides compounds of Formula I, compositions and methods that are useful for treating viral infections and associated diseases, particularly HCV infections and associated diseases.Type: ApplicationFiled: June 30, 2003Publication date: July 22, 2004Inventors: Carlo Battistini, Francesco A. Casuscelli, Robert Charles Kelly, Linda L. Maggiora, Mark Allen Mitchell, Claudia Piutti, Matthew T. Reding
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Patent number: 6245742Abstract: The present invention relates to peptides and peptidomimetic compounds and pharmaceutical compositions containing them as useful pharmacological agents in the control or treatment of proliferative diseases such as cancer, against tumor growing and/or tumoral metastasis, and psoriasis and in the control or treatment of inflammatory, allergic, autoimmune, viral, and cardiovascular diseases. These new compounds have the unique property to inhibit the recognition of several phosphotyrosine containing motifs within all the cellular receptors and cytosolic transducers by a wide spectrum of SH2 domains contained in cytosolic transducers and other effector proteins laying along different pathways of the signal transduction process and with a particularly high affinity for the SH2 domain of the adaptor transducer Grb2, a key element along the pathway to mitogenesis and motogenesis, this last activity leading to invasiveness and to metastasis.Type: GrantFiled: October 15, 1997Date of Patent: June 12, 2001Assignee: Pharmacia & Upjohn S.p.A.Inventors: Carlo Battistini, Patrizia Giordano, Sabrina De Rosa, Fabio Corradi, Paolo Comoglio, Alberto Bardelli
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Patent number: 6147073Abstract: A tetralylmethylene-2-oxindole derivative having the following formula (I) ##STR1## wherein one or two of R, R.sub.1, R.sub.2 and R.sub.3 the said two being the same or different, are selected from:a) --X--(CH.sub.2).sub.m --NH.sub.2, --X--(CH.sub.2).sub.m --NR.sub.4 R.sub.5 or --X--(CH.sub.2).sub.m --NHR.sub.6, in which X is --O--, --S-- or --NH--, m is an integer of 2 to 4, one of R.sub.4 and R.sub.5 is hydrogen or C.sub.1 -C.sub.6 alkyl and the other is C.sub.1 -C.sub.6 alkyl or R.sub.4 and R.sub.5 taken together with the N atom to which they are linked form a 5 to 7 membered saturated heteromonocycle, and R.sub.6 is C.sub.2 -C.sub.6 alkanoyl or a C-terminally linked peptidyl residue containing from 1 to 3 aminoacids wherein the terminal amino group is either free or protected or in an alkylated form to provide a --NR.sub.4 R.sub.5 group in which R.sub.4 and R.sub.5 are as defined above.Type: GrantFiled: January 12, 1998Date of Patent: November 14, 2000Assignee: Pharmacia & Upjohn S.p.A.Inventors: Carlo Battistini, Antonella Ermoli, Sergio Vioglio, Franco Buzzetti, Dario Ballinari
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Patent number: 5922750Abstract: The present invention relates to terpenoidic derivatives, known in the art as Sarcodictyins, for use as therapeutic agents, and to pharmaceutical compositions containing them.In particular, Sarcodictyins can be useful as therapeutic antineoplastic agents in the treatment of cancers in human or animal beings.Type: GrantFiled: August 7, 1998Date of Patent: July 13, 1999Assignee: Pharmacia & Upjohn S.p.A.Inventors: Carlo Battistini, Marina Ciomei, Francesco Pietra, Michele D'Ambrosio, Antonio Guerriero
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Patent number: 5905149Abstract: Quinolylmethylen-oxindole derivatives having general formula (I), wherein R is H or --(CH.sub.2).sub.n --COR.sub.7 group in which n is an integer of 1 to 4 and R.sub.7 is hydroxy, amino, C.sub.1 -C.sub.6 alkoxy or --NR.sub.5 R.sub.6 in which one of R.sub.5 and R.sub.6 is hydrogen or C.sub.1 -C.sub.6 alkyl and the other is C.sub.1 -C.sub.6 alkyl or R.sub.5 and R.sub.6 taken together with the N atom to which they are linked form a 5 to 7 membered saturated heteromonocycle or R.sub.7 is a N-terminally linked peptidyl residue containing from 1 to 3 aminoacids in which the terminal carboxyl group may be present as such, as amide, as alkali metal salt or as a C.sub.1 -C.sub.4 alkyl ester, one or two of R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, are selected from: a) --X--(CH.sub.2).sub.m --NH.sub.2, --X--(CH.sub.2).sub.m --NR.sub.5 R.sub.6 or --X--(CH.sub.2).sub.m --NHR.sub.8 group; b) --NH--C(.dbd.NH)--NR.sub.5 R.sub.6, --NH--C(.dbd.NH)--NHR.sub.8, --N.dbd.CH--NH.sub.2, --N.dbd.Type: GrantFiled: January 29, 1998Date of Patent: May 18, 1999Assignee: Pharmacia & Upjohn S.p.AInventors: Carlo Battistini, Antonella Ermoli, Sergio Vioglio, Franco Buzzetti, Dario Ballinari
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Patent number: 5869514Abstract: A method of treating tumors in a human or animal by administering thereto a pharmaceutically effective amount of a Sarcodictyin compound selected from Sarcodictyin A, B, C, D, E, and F. Sarcodictyin A has the formula (-)-(4R,4aR,7R,10S,11S,12aR,1Z,5E,8Z)-7,10-Epoxy3,4,4a,7,10,11,12,12a-octa hydro-7-hydroxy-6-(methoxy-carbonyl)-1,10- dimethyl-4-(1-methylethyl)benzo cyclodecen-11-yl(E)-3-(1-Methyl-1H-imidazol-4-yl) acrylate (Sarcodictyin A).Type: GrantFiled: January 15, 1997Date of Patent: February 9, 1999Assignee: Pharmacia & Upjohn S.p.A.Inventors: Carlo Battistini, Marina Ciomei, Francesco Pietra, Michele D'Ambrosio, Antonio Guerriero
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Patent number: 5849710Abstract: The present invention relates to indol-3-ylmethylene-2-oxindole derivatives which are useful as tyrosine kinase inhibitors. The compounds are suitable for use as anti-proliferative agents, anti-metastatic agents, anti-cancer agents, and in the control of angiogenesis and in inhibiting the development of atheromatous and an immunomogulating agents.Type: GrantFiled: December 4, 1996Date of Patent: December 15, 1998Assignee: Pharmacia & Upjohn S.p.A.Inventors: Carlo Battistini, Dario Ballinari, Antonella Ermoli, Sergio Penco, Sergio Vioglio
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Patent number: 5547941Abstract: There are provided compounds of formula (I) ##STR1## wherein each group B is, independently, a naturally occurring or modified heterocyclic base linked through a nitrogen or a carbon atom of the ring to the sugar moiety;each group X is a, independently, hydrogen, fluorine, hydroxy, or a C.sub.1 -C.sub.6 alkoxy group;each group Y is, independently, hydrogen, sulphidryl or hydroxy; and the pharmaceutically acceptable salts thereof.A process for their preparation and pharmaceutical compositions comprising them are also described. The compounds of this invention can be useful as antivirals, particularly as anti-HIV (Human Immunodeficiency Virus) agents, namely as drugs to be used against AIDS (Acquired Immunodeficiency Syndrome) therapeutically and/or prophylatically.Type: GrantFiled: December 9, 1994Date of Patent: August 20, 1996Assignee: Farmitalia Carlo Erba S.R.L.Inventors: Carlo Battistini, Silvia Fustinoni, Maria G. Brasca, Domenico Ungheri
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Patent number: 5374626Abstract: The present invention relates to the use as antivirals of compounds of formula: ##STR1## wherein B is a purinic or pyrimidinic heterocycle; X is oxygen or sulphur; R.sup.1 is a hydroxyl group or a hydrogen atom; R.sup.2 is a linear, branched or cyclic, alkyl group of up to twenty carbon atoms; R.sup.3 is as specified for R.sup.2 above or a hydrogen atom, a cation or a polyhydroxy group.Type: GrantFiled: March 12, 1993Date of Patent: December 20, 1994Assignee: Farmitalia Carlo ERBAInventors: Carlo Battistini, Giovanni Franceschi, Domenico Ungheri, Maria A. Verini, Sergio Vioglio
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Patent number: 5302588Abstract: A crystalline form of (5R,6S)-2-carbamoyloxymethyl-6-[(1R)-hydroxyethyl]-2-penem-3-carboxylic acid incorporates two molecules of water per molecule of the acid and is useful as an antibacterial agent.Type: GrantFiled: June 16, 1992Date of Patent: April 12, 1994Assignee: Farmitalia Carlo ErbaInventors: Carlo Battistini, Roberto Bianchini, Stefano del Nero, Pierluigi Griggi, Sergio Vioglio
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Patent number: 5288704Abstract: A pharmaceutcial composition is provided for use in the prevention or treatment of viral infections caused by enveloped viruses. The composition comprises a fibroblast growth factor, a sulfated polysaccharide with antiviral activity, and one or more pharmaceutically acceptable carriers. The fibroblast growth factor may be a basic fibroblast growth factor or an analogue thereof, and the polysaccharide may be a carrageenan, heparin, dextran sulfate, pentosan polysulfate or a sulfated polysaccharides produced by marine algae belonging to the class of Rhodophyceae.Type: GrantFiled: January 31, 1992Date of Patent: February 22, 1994Assignee: Farmitalia Carlo Erba S.R.L.Inventors: Domenico Ungheri, Luisa Garofano, Carlo Battistini, Paolo Carminati, Guy Mazue
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Patent number: 4631150Abstract: A process for preparing 2-methyl substituted penems useful as antibiotics agent and/or as intermediates thereof, by reacting an appropriate 1-imido-3,4-disubstituted azetidinone derivative with a trivalent organophosphorus compound in an inert solvent at a temperature of from 110.degree. to 150.degree. C. for a period of from 2 hours to a few days.Type: GrantFiled: August 6, 1984Date of Patent: December 23, 1986Assignee: Farmitalia Carlo Erba S.p.A.Inventors: Carlo Battistini, Maurizio Foglio, Giovanni Franceschi, Cosimo Scarafile
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Patent number: 4508649Abstract: Processes for the preparation of a penem derivative of formula I ##STR1## wherein n=0 or 1; R is a carboxy protecting group or H;R.sub.1 is hydrogen, a hydrocarbon group substituted or unsubstituted, or lower alkoxy; andR.sub.2 is hydrogen, C.sub.1 -C.sub.5 alkyl, carbamoyl N-substituted by lower alkyl or unsubstituted, or an acyl group;and the pharmaceutically acceptable salts thereof.These processes allow one to prepare stereospecifically only 5R derivatives, and are characterized by R.sub.2 -introduction at a very late stage in the synthesis, thereby enabling a great number of compounds of formula I to be prepared.Penem derivatives are useful antibacterial agents.Type: GrantFiled: December 6, 1982Date of Patent: April 2, 1985Assignee: Farmitalia Carlo ErbaInventors: Marco Alpegiani, Carlo Battistini, Angelo Bedeschi, Giovanni Franceschi, Maurizio Foglio, Franco Zarini
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Patent number: 4337248Abstract: Compounds are disclosed of the formula ##STR1## wherein R.sub.1 represents a hydrogen or chlorine atom, as well as intermediates. These include 4'-deoxy-paromomycin; 4'-deoxy-4'-epi-chloro-paromomycin; 4'-deoxy-4'-epi-chloro-penta-N-benzyloxycarbonylparomomycin; 4'-deoxy-penta-N-benzyloxycarbonylparomomycin; 6,3',2",5",3"',4"'-hexa-O-acetyl-6'-O-benzoyl-4'-deoxy-penta-N-benzyloxyca rbonylparomomycin; 6,3',2",5",3"',4"'-hexa-O-acetyl-6'-O-benzoyl-4'-epi-chloro-4'-deoxy-penta -N-benzyloxycarbonylparomomycin; 6,3',2",5",3"',4"'-hexa-O-acetyl-6'-O-benzyl-penta-N-benzyloxycarbonylparo momycin; 6,3',2",5",3"',4"'-hexa-O-acetyl-6'-O-benzoyl-4'-O-[(methylthio)-thiocarbo nyl]-penta-N-benzyloxycarbonylparomomycin; and 6,3',2",5",3"',4"'-hexa-O-acetyl-6'-O-benzoyl-4'-O-[(phenylthio)-thiocarbo nyl]-penta-N-benzyloxycarbonylparomomycin. The compounds illustrated by the structural formula are useful in treating amoebic dysentery in man and animals.Type: GrantFiled: June 4, 1980Date of Patent: June 29, 1982Assignee: Farmitalia Carlo Erba S.p.A.Inventors: Carlo Battistini, Giuseppe Cassinelli, Giovanni Franceschi, Rosanna Mazzoleni, Federico Arcamone