Patents by Inventor Carlo Croce
Carlo Croce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040152112Abstract: The miR15 and miR16 micro RNA genes are located at 13q14 within a 30 kb region of loss characteristic of cells from certain cancers, such as cells from chronic lymphocytic leukemia or prostate cancer. Chronic lymphocytic leukemia or prostate cancer can be diagnosed by detecting a reduction in miR15 or miR16 gene copy number, by determining miR15 or miR16 gene mutational status, or by detecting a reduction in the RNA transcribed from these genes. The miR15 or miR16 gene products can inhibit the neoplastic or tumorigenic growth of cancers such as chronic lymphocytic leukemia or prostate cancer cells when administered to subjects suffering from these diseases.Type: ApplicationFiled: November 12, 2003Publication date: August 5, 2004Applicant: Thomas Jefferson UniversityInventors: Carlo Croce, George Calin
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Publication number: 20020086331Abstract: In invertebrates, Fhit is encoded as a fusion protein with Nit. Outside of invertebrates, Nit homologs are found as separate polypeptides in organisms with Fhit homologs. Therefore, Nit and Fhit are expected to interact physically and function in the same cellular pathway. The structure of the NitFhit fusion protein and interactions between the Nit and Fhit polypeptides are defined. The present invention relates to the identification of small molecules that interact with, and regulate, the Nit protein. The present invention further relates to therapeutic compositions and their uses in regulating Nit activity, thereby modulating cellular proliferation.Type: ApplicationFiled: May 15, 2001Publication date: July 4, 2002Inventors: Carlo Croce, Charles Brenner, Yuri Pekarsky
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Patent number: 6040140Abstract: The cDNA sequence of the ALL-1 gene on chromosome 11 is provided. A partial sequence of the AF-4 gene is also provided in the context of the sequences of two reciprocal endproducts of a translocation. Amino acid sequences corresponding to the cDNA sequences of the entire ALL-1 gene and the partial sequence of the AF-4 gene, and sequences relating to chimeric genes formed by chromosome translocations with chromosome 4, 9 and 19, respectively, are provided. Probes are provided for detecting chromosome abnormalities involving the ALL-1 gene on chromosome 11, including probes for detecting chimeric genes generated by translocations. Monoclonal antibodies for diagnosis and treatment and antisense oligonucleotides for treatment of acute leukemias are also described.Type: GrantFiled: March 7, 1996Date of Patent: March 21, 2000Assignee: Thomas Jefferson UniversityInventors: Carlo Croce, Eli Canaani
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Patent number: 5939258Abstract: A method of diagnosing prostate micrometastasis is provided by the present invention whereby nucleic acids from a tissue sample from a patient are isolated, nucleic acids from the tissue sample specific for prostate cancer are amplified, or a signal generated by hybridization of a probe specific to a prostate cancer specific nucleic acid is amplified; and detection of amplified nucleic acids is indicative of micrometastasis of prostate cancer.Type: GrantFiled: December 12, 1996Date of Patent: August 17, 1999Assignee: Thomas Jefferson UniversityInventors: Carlo Croce, Leonard Gomella, S. Grant Mulholland, Jose G. Moreno, Rainer Fischer
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Patent number: 5688649Abstract: A method of diagnosing prostate metastasis is provided by the present invention whereby RNA from a patient's blood is isolated and amplified using a pair of primers which are complementary to regions of the prostate specific antigen gene. The presence or absence of amplified RNA is detected and the presence of amplified RNA is indicative micrometastasis of prostate cancer.Type: GrantFiled: February 5, 1996Date of Patent: November 18, 1997Assignee: Thomas Jefferson UniversityInventors: Carlo Croce, Leonard Gomella, S. Grant Mulholland, Jose G. Moreno, Rainer Fischer
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Patent number: 5674682Abstract: Oligonucleotides for and a method of diagnosing prostate micrometastasis are provided by the present invention whereby nucleic acids from a tissue sample from a patient are isolated, nucleic acids from the tissue sample specific for prostate cancer are amplified, or a signal generated by hybridization of a probe specific to a prostate cancer specific nucleic acid is amplified; and detection of amplified nucleic acids is indicative of micrometastasis of prostate cancer.Type: GrantFiled: December 15, 1994Date of Patent: October 7, 1997Assignee: Thomas Jefferson UniversityInventors: Carlo Croce, Leonard Gomella, S. Grant Mulholland, Jose G. Moreno, Rainer Fischer
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Patent number: 5633135Abstract: Methods are provided for the diagnosis and treatment of human leukemias involving breakpoints on chromosome 11 in the ALL-1 locus. The ALL-1 breakpoint region, an approximately 8 kb region on chromosome 11, is also disclosed. The ALL-1 region is involved in translocations in acute lymphocytic, myelomonocytic, monocytic and myelogenous leukemias. Probes which identify chromosome aberrations involving the ALL-1 breakpoint region on chromosome 11 are also provided. cDNA sequences of the ALL-1 gene on chromosome 11, the AF-9 gene on chromosome 9 and the AF-4 gene, and corresponding amino acid sequences are also provided. Probes are provided for detecting chromosome abnormalities involving theses genes. Chimeric genes involved in translocations are disclosed. Monoclonal antibodies for diagnosis and treatment and antisense oligonucleotides for treatment of acute leukemias are also described.Type: GrantFiled: October 11, 1994Date of Patent: May 27, 1997Assignee: Thomas Jefferson UniversityInventors: Carlo Croce, Eli Canaani
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Patent number: 5633136Abstract: Methods are provided for the diagnosis and treatment of human leukemias involving breakpoints on chromosome 11 in the ALL-1 locus. The ALL-1 breakpoint region, an approximately 8 kb region on chromosome 11 is also disclosed. The ALL-1 region is involved in translocations in acute lymphocytic, mylemonocytic, monocytic, and myelogenous leukemias. Probes which identify chromosome aberrations involving the ALL-1 breakpoint region on chromosome 11 are also provided. The cDNA sequence of the ALL-1 gene on chromosome 11 is provided. A partial sequence of the AF-4 gene is also provided in the context of the sequences of the two reciprocal end products of a translocation. Amino acid sequences corresponding to the cDNA sequences of the entire ALL-1 gene and the partial sequence of the AF-4 gene are also provided. Probes are provided for detecting chromosomal abnormalities involving the ALL-1 gene on chromosome 11.Type: GrantFiled: October 19, 1994Date of Patent: May 27, 1997Assignee: Thomas Jefferson UniversityInventors: Carlo Croce, Eli Canaani
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Patent number: 5523393Abstract: The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes 14 and 18. This translocation is involved in the majority of cases of human follicular lymphomas. One assay employs an antibody which is immunoreactive with a human protein which is over-expressed due to the chromosome translocation. Another assay involves measurement of the amount of mRNA which hybridizes to the gene proximal to the translocation break-point.Type: GrantFiled: May 5, 1995Date of Patent: June 4, 1996Assignee: The Wistar InstituteInventors: Yoshihide Tsujimoto, Carlo A. Croce
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Patent number: 5506344Abstract: The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes 14 and 18. This translocation is involved in the majority of cases of human follicular lymphomas. One assay employs an antibody which is immunoreactive with a human protein which is over-expressed due to the chromosome translocation. Another assay involves measurement of the amount of mRNA which hybridizes to the gene proximal to the translocation break-point.Type: GrantFiled: May 5, 1995Date of Patent: April 9, 1996Assignee: The Wistar InstituteInventors: Yoshihide Tsujimoto, Carlo A. Croce
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Patent number: 5506106Abstract: A method of diagnosing prostate metastasis is provided by the present invention whereby RNA from a patient's blood is isolated and amplified using a pair of primers which are complementary to regions of the prostate specific antigen gene. The presence or absence of amplified RNA is detected and the presence of amplified RNA is indicative micrometastasis of prostate cancer.Type: GrantFiled: August 23, 1994Date of Patent: April 9, 1996Assignee: Thomas Jefferson UniversityInventors: Carlo Croce, Leonard Gomella, S. Grant Mulholland, Jose G. Moreno, Rainer Fischer
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Patent number: 5459251Abstract: The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes 14 and 18. This translocation is involved in the majority of cases of human follicular lymphomas. One assay employs an antibody which is immunoreactive with a human protein which is over-expressed due to the chromosome translocation. Another assay involves measurement of the amount of mRNA which hybridizes to the gene proximal to the translocation break-point.Type: GrantFiled: April 18, 1994Date of Patent: October 17, 1995Assignee: The Wistar InstituteInventors: Yoshihide Tsujimoto, Carlo A. Croce
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Patent number: 5202429Abstract: The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes 14 and 18. The translocation is involved in the majority of cases of human follicular lymphomas. One assay employs an antibody which is immunoreactive with a human protein which is over-expressed due to the chromosome translocation. Another assay involves measurement of the amount of mRNA which hybridizes to the gene proximal to the translocation break-point.Type: GrantFiled: March 19, 1991Date of Patent: April 13, 1993Assignee: The Wistar InstituteInventors: Yoshihide Tsujimoto, Carlo A. Croce
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Patent number: 5015568Abstract: The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes 14 and 18. This translocation is involved in the majority of cases of human follicular lymphomas. One assay employs an antibody which is immunoreactive with a human protein which is over-expressed due to the chromosome translocation. Another assay involves measurement of the amount of mRNA which hybridizes to the gene proximal to the translocation break-point.Type: GrantFiled: July 9, 1986Date of Patent: May 14, 1991Assignee: The Wistar InstituteInventors: Yoshihide Tsujimoto, Carlo A. Croce