Patents by Inventor Carlo Effenhauser
Carlo Effenhauser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9063038Abstract: A device for sampling, transporting and/or disposal of fluid media in the nl and ?l-range comprises a substrate with an open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open or closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.Type: GrantFiled: March 13, 2013Date of Patent: June 23, 2015Assignee: Roche Diagnostics Operations, Inc.Inventors: Carlo Effenhauser, Patrick Griss, Stephan Korner, Emad Sarofim
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Patent number: 8911684Abstract: A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.Type: GrantFiled: June 4, 2012Date of Patent: December 16, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Manfred Augstein, Christoph Boehm, Carlo Effenhauser, Rijk Edwin Oosterbroek, Susanne Wuerl
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Patent number: 8911683Abstract: A microfluidic device is provided including at least one chamber accessible by microfluidic channels characterized in that the surface of the channels and the chambers are patterned and comprise hydrophilic and hydrophobic areas. The surface energy in correspondence of the areas, i.e., the capillary force, being such that a liquid can be guided along the hydrophilic path, enter the chamber from one side, wet part of one surface of the chamber as a thin layer without touching the opposite surface of the chamber, thus avoiding to fill the volume inside the chamber in correspondence of the hydrophilic pattern until a second liquid, either sequentially or in parallel, comes to wet part of the opposite surface of the chamber and eventually touches the first liquid layer, resulting in a sudden coalescence and efficient mixing between the liquids.Type: GrantFiled: June 19, 2008Date of Patent: December 16, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Mario Curcio, Carlo Effenhauser, Michael Glauser
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Patent number: 8821413Abstract: A system is provided for withdrawing small amounts of body fluid from an animal or human. The system includes a holder and a disposable lancing unit attached to the holder. The lancing unit also includes an open capillary channel for transporting the body fluid and piercing the skin.Type: GrantFiled: February 20, 2013Date of Patent: September 2, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Carlo Effenhauser, Heinz-Michael Hein, Karl-Heinz Koelker, Frank Deck
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Patent number: 8420024Abstract: A device for sampling, transporting and/or disposal of fluid media in the nl and ?l-range comprises a substrate with an open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open or closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.Type: GrantFiled: April 4, 2012Date of Patent: April 16, 2013Assignee: Roche Diagnostics Operations, Inc.Inventors: Stephan Korner, Patrick Griss, Emad Sarofim, Carlo Effenhauser
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Patent number: 8388552Abstract: A system is provided for withdrawing small amounts of body fluid from an animal or human. The system includes a holder and a disposable lancing unit attached to the holder. The lancing unit also includes an open capillary channel for transporting the body fluid and piercing the skin.Type: GrantFiled: June 30, 2011Date of Patent: March 5, 2013Assignee: Roche Diagnostics Operations, Inc.Inventors: Carlo Effenhauser, Heinz-Michael Hein, Karl-Heinz Koelker, Frank Deck
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Publication number: 20120301371Abstract: A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.Type: ApplicationFiled: June 4, 2012Publication date: November 29, 2012Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Manfred Augstein, Christoph Boehm, Carlo Effenhauser, Rijk Edwin Oosterbroek, Susanne Wuerl
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Publication number: 20120230885Abstract: A device for sampling, transporting and/or disposal of fluid media in the nl and ?l-range comprises a substrate with an open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open or closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.Type: ApplicationFiled: April 4, 2012Publication date: September 13, 2012Inventors: Stephan Korner, Patrick Griss, Emad Sarofim, Carlo Effenhauser
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Patent number: 8241566Abstract: A device for sampling, transporting and/or disposal of fluid media in the nl and ?l-range comprises a substrate with and open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.Type: GrantFiled: November 22, 2005Date of Patent: August 14, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Stephan Korner, Patrick Griss, Emad Sarofim, Carlo Effenhauser
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Publication number: 20110257559Abstract: A system is provided for withdrawing small amounts of body fluid from an animal or human. The system includes a holder and a disposable lancing unit attached to the holder. The lancing unit also includes an open capillary channel for transporting the body fluid and piercing the skin.Type: ApplicationFiled: June 30, 2011Publication date: October 20, 2011Inventors: Carlo Effenhauser, Heinz-Michael Hein, Harl-Heinz Koelker, Frank Deck
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Publication number: 20110223080Abstract: A micro fluidic device comprises a laminate structure, comprising a plurality of individual layers. At least one layer comprises a micro fluidic channel structure and at least on one side of said layer a further layer is arranged comprising a three-dimensional (3D) micro structure such that the 3D micro structure is influencing a flow characteristic of a fluid within the micro fluidic channel structure.Type: ApplicationFiled: May 24, 2011Publication date: September 15, 2011Inventors: Roger Sandoz, Carlo Effenhauser
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Patent number: 7993284Abstract: A system is provided for withdrawing small amounts of body fluid from an animal or human. The system includes a holder and a disposable lancing unit attached to the holder. The lancing unit also includes an open capillary channel for transporting the body fluid and piercing the skin.Type: GrantFiled: September 20, 2007Date of Patent: August 9, 2011Assignee: Roche Diagnostics Operations, Inc.Inventors: Carlo Effenhauser, Heinz-Michael Hein, Karl-Heinz Koelker, Frank Deck
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Patent number: 7977122Abstract: A micro fluidic device comprises a laminate structure, comprising a plurality of individual layers. At least one layer comprises a micro fluidic channel structure and at least on one side of said layer a further layer is arranged comprising a three-dimensional (3D) micro structure such that the 3D micro structure is influencing a flow characteristic of a fluid within the micro fluidic channel structure.Type: GrantFiled: January 31, 2007Date of Patent: July 12, 2011Assignee: Roche Diagnostics Operations, Inc.Inventors: Roger Sandoz, Carlo Effenhauser
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Patent number: 7760346Abstract: The invention relates to a method and an apparatus for analyzing a dry-chemical test element, in particular an immunological test element, wherein, in the method, a dry-chemical test element is analyzed by optical scanning, whereby measurement light beams leaving assay regions of the test element, which are loaded with one or more immobilized optically active substances, with a respective measurement light intensity are detected by a detector device.Type: GrantFiled: September 9, 2008Date of Patent: July 20, 2010Assignee: Roche Diagnostics Operations, Inc.Inventors: Carlo Effenhauser, Erich Haendler, Norbert Oranth
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Patent number: 7682430Abstract: The invention concerns a device which is used to separate gas or liquid from microfluidic flow-through systems. The gas or liquid separation is achieved independently of the spatial orientation of the device. In addition the invention concerns a microfluidic flow-through system in which a device according to the invention enables bubble-free fluid transport.Type: GrantFiled: August 13, 2002Date of Patent: March 23, 2010Assignee: Roche Diagnostics CorporationInventors: Peter Kraemer, Carlo Effenhauser, Karl-Heinz Koelker, Gregor Ocvirk
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Patent number: 7645369Abstract: A separation device and a separation method for biomolecular sample material and in particular protein mixtures. For this purpose a separation element 10 for the two-dimensional and preferable electrophoretic separation of components of the sample material is provided in area 30 of a separation plane. According to the invention it is proposed that the separation element 10 has a channel or transfer structure 14 for the locally resolved discharge of separated sample components in a transport direction that is at right angles to the separation plane onto a support surface 16 that is preferably suitable for mass spectroscopic analyses.Type: GrantFiled: May 2, 2005Date of Patent: January 12, 2010Assignee: Roche Diagnositcs Operations, Inc.Inventors: Hans-Joachim Hoeltke, Albert Roeder, Alois Rainer, Peter Berndt, Carlo Effenhauser, Hanno Langen, Remo Anton Hochstrasser
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Patent number: 7527740Abstract: A method for separating particles from a fluid dispersion, particularly for separating corpuscular components from biological samples, above all from blood. A separating module suitable for performing the method has a substrate with flow channels, comprising a feed channel for supplying the dispersion to a junction, a first drain channel for draining fluid having a reduced particle concentration away from the junction, and a second drain channel for draining fluid having an increased particle concentration away from the junction. The fluid flows so much faster in the second drain channel than in the first drain channel that due to the different flow speeds the dispersed particles preferentially flow at the junction further in the second drain channel.Type: GrantFiled: September 14, 2002Date of Patent: May 5, 2009Assignee: Roche Diagnostics Operations, Inc.Inventors: Carlo Effenhauser, Gregor Ocvirk, Wolfgang Fiedler
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Publication number: 20090086195Abstract: The invention relates to a method and an apparatus for analyzing a dry-chemical test element, in particular an immunological test element, wherein, in the method, a dry-chemical test element is analyzed by optical scanning, whereby measurement light beams leaving assay regions of the test element, which are loaded with one or more immobilized optically active substances, with a respective measurement light intensity are detected by a detector device.Type: ApplicationFiled: September 9, 2008Publication date: April 2, 2009Applicant: Roche Diagnostics Operations.IncInventors: Carlo Effenhauser, Erich Haendler, Norbert Oranth
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Publication number: 20090016932Abstract: A microfluidic device is provided including at least one chamber accessible by microfiuidic channels characterized in that the surface of the channels and the chambers are patterned and comprise hydrophilic and hydrophobic areas. The surface energy in correspondence of the areas, i.e., the capillary force, being such that a liquid can be guided along the hydrophilic path, enter the chamber from one side, wet part of one surface of the chamber as a thin layer without touching the opposite surface of the chamber, thus avoiding to fill the volume inside the chamber in correspondence of the hydrophilic pattern until a second liquid, either sequentially or in parallel, comes to wet part of the opposite surface of the chamber and eventually touches the first liquid layer, resulting in a sudden coalescence and efficient mixing between the liquids.Type: ApplicationFiled: June 19, 2008Publication date: January 15, 2009Inventors: Mario Curcio, Carlo Effenhauser, Michael Glauser
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Publication number: 20080009767Abstract: A system is provided for withdrawing small amounts of body fluid from an animal or human. The system includes a holder and a disposable lancing unit attached to the holder. The lancing unit also includes an open capillary channel for transporting the body fluid and piercing the skin.Type: ApplicationFiled: September 20, 2007Publication date: January 10, 2008Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Carlo Effenhauser, Heinz-Michael Hein, Karl-Heinz Koelker, Frank Deck