Patents by Inventor Carlo G. Tocchetti

Carlo G. Tocchetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10786543
    Abstract: The present invention provides 75 kD transmembrane neurotrophin receptor (p75NTR) antagonists and their use in prevention and treatment of loss of function, and adverse remodeling, in cardiac tissues subject to acute or chronic hemodynamic stress. Uses of the antagonists with or without additional cardiotropic agents for improving contractility and for treatment of congestive heart failure are also provided.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: September 29, 2020
    Assignees: The Johns Hopkins University, Vanderbilt University
    Inventors: Nazareno Paolocci, Ning Feng, Carlo G. Tocchetti, Cyrus Takahashi, Bruce Carter
  • Publication number: 20180271931
    Abstract: The present invention provides 75 kD transmembrane neurotrophin receptor (p75NTR) antagonists and their use in prevention and treatment of loss of function, and adverse remodeling, in cardiac tissues subject to acute or chronic hemodynamic stress. Uses of the antagonists with or without additional cardiotropic agents for improving contractility and for treatment of congestive heart failure are also provided.
    Type: Application
    Filed: September 22, 2016
    Publication date: September 27, 2018
    Inventors: Nazareno Paolocci, Ning Feng, Carlo G. Tocchetti, Cyrus Takahashi, Bruce Carter
  • Publication number: 20160166604
    Abstract: The present invention relates to methods for treating diastolic dysfunction or a disease, disorder or condition associated with diastolic dysfunction, methods for treating heart failure, methods for modulating SR Ca2+ release and/or uptake, methods for enhancing myocyte relaxation, preload or E2P hydrolysis, and methods for treating ventricular hypertrophy.
    Type: Application
    Filed: March 9, 2015
    Publication date: June 16, 2016
    Inventors: Nazareno Paolocci, David A. Kass, Carlo G. Tocchetti
  • Publication number: 20090298795
    Abstract: The present invention relates to methods for treating diastolic dysfunction or a disease, disorder or condition associated with diastolic dysfunction, methods for treating heart failure, methods for modulating SR Ca2+ release and/or uptake, methods for enhancing myocyte relaxation, preload or E2P hydrolysis, and methods for treating ventricular hypertrophy.
    Type: Application
    Filed: June 23, 2006
    Publication date: December 3, 2009
    Applicant: THE JOHNS HOPINS UNIVERSITY
    Inventors: Nazareno Paolocci, David A. Kass, Carlo G. Tocchetti