Patents by Inventor Carlo Napolitano

Carlo Napolitano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF ALLELE SPECIFIC SILENCING FOR THE TREATMENT OF AUTOSOMAL DOMINANT CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA (CPVT)
    Publication number: 20240067974
    Abstract: The present invention provides a method for the treatment of autosomal dominant Catecholaminergic Polymorphic Ventricular Tachycardia associated with mutations in the cardiac ryanodine receptor type 2 (RYR2) gene, by the use of an AAV mediated RNA interference approach to induce allele specific silencing of mutant mRNA.
    Type: Application
    Filed: February 27, 2023
    Publication date: February 29, 2024
    Inventors: Silvia G. PRIORI, Rossana BONGIANINO, Marco DENEGRI, Carlo NAPOLITANO
  • Method of allele specific silencing for the treatment of autosomal dominant Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
    Patent number: 11591602
    Abstract: The present invention provides a method for the treatment of autosomal dominant Catecholaminergic Polymorphic Ventricular Tachycardia associated with mutations in the cardiac ryanodine receptor type 2 (RYR2) gene, by the use of an AAV mediated RNA interference approach to induce allele specific silencing of mutant mRNA.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: February 28, 2023
    Assignee: Istituti Clinici Scientifici Maugeri SpA SB
    Inventors: Silvia G. Priori, Rossana Bongianino, Marco Denegri, Carlo Napolitano
  • Method of gene transfer for the treatment of recessive catecholaminergic polymorphic ventricular tachycardia (CPVT)
    Patent number: 11173215
    Abstract: The present invention concerns a method for the treatment of recessive Catecholaminergic Polymorphic Ventricular Tachycardia comprising delivering a gene into a cardiac cell.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: November 16, 2021
    Assignee: Istituti Clinici Scientifici Maugeri SpA SB
    Inventors: Silvia G. Priori, Carlo Napolitano, Marco Denegri
  • METHOD OF ALLELE SPECIFIC SILENCING FOR THE TREATMENT OF AUTOSOMAL DOMINANT CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA (CPVT)
    Publication number: 20210189401
    Abstract: The present invention provides a method for the treatment of autosomal dominant Catecholaminergic Polymorphic Ventricular Tachycardia associated with mutations in the cardiac ryanodine receptor type 2 (RYR2) gene, by the use of an AAV mediated RNA interference approach to induce allele specific silencing of mutant mRNA.
    Type: Application
    Filed: February 14, 2017
    Publication date: June 24, 2021
    Inventors: Silvia G. PRIORI, Rossana BONGIANINO, Marco DENEGRI, Carlo NAPOLITANO
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF DOMINANTLY-INHERITED CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA
    Publication number: 20210030894
    Abstract: Compositions and methods for the treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT), particularly forms of the disease that are inherited in an autosomal dominant manner, by way of calsequestrin 2 (CASQ2) gene therapy can be used to treat CPVT caused by mutations in, for example, ryanodine receptor 2 and calmodulin, such as calmodulin 1 (CALM1) and CALM3. A variety of vectors are provided that can be used for the delivery of a CASQ2 transgene to a patient, such as a human patient suffering from autosomal dominant CPVT, including adeno-associated virus vectors, among others.
    Type: Application
    Filed: April 5, 2019
    Publication date: February 4, 2021
    Inventors: Silvia G. PRIORI, Andrea MAZZANTI, Marco DENEGRI, Carlo NAPOLITANO
  • METHOD OF GENE TRANSFER FOR THE TREATMENT OF RECESSIVE CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA (CPVT)
    Publication number: 20190381191
    Abstract: The present invention concerns a method for the treatment of recessive Catecholaminergic Polymorphic Ventricular Tachycardia comprising delivering a gene into a cardiac cell.
    Type: Application
    Filed: January 28, 2019
    Publication date: December 19, 2019
    Inventors: Silvia G. Priori, Carlo Napolitano, Marco Denegri
  • Method of gene transfer for the treatment of recessive catecholaminergic polymorphic ventricular tachycardia (CPVT)
    Patent number: 10195292
    Abstract: The present invention concerns a method for the treatment of recessive Catecholaminergic Polymorphic Ventricular Tachycardia comprising delivering a gene into a cardiac cell.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: February 5, 2019
    Assignee: Istituti Clinici Scientifici Maugeri SpA SB
    Inventors: Silvia G. Priori, Carlo Napolitano, Marco Denegri
  • METHOD OF GENE TRANSFER FOR THE TREATMENT OF RECESSIVE CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA (CPVT)
    Publication number: 20170360957
    Abstract: The present invention concerns a method for the treatment of recessive Catecholaminergic Polymorphic Ventricular Tachycardia comprising delivering a gene into a cardiac cell.
    Type: Application
    Filed: May 30, 2017
    Publication date: December 21, 2017
    Inventors: Silvia G. PRIORI, Carlo NAPOLITANO, Marco DENEGRI
  • Method of gene transfer for the treatment of recessive catecholaminergic polymorphic ventricular tachycardia (CPVT)
    Patent number: 9700636
    Abstract: The present invention concerns a method for the treatment of recessive Catecholaminergic Polymorphic Ventricular Tachycardia comprising delivering a gene into a cardiac cell. The methods described herein relate to the use of viral vectors, such as adeno-associated virus (AAV) vectors, for the delivery of calsequestrin 2 (CASQ2) to cells, such as cardiomyocytes, so as to treat pathologies associated with mutations in this gene.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: July 11, 2017
    Assignee: Istituti Clinici Scientifici Maugeri SpA SB
    Inventors: Silvia G. Priori, Carlo Napolitano, Marco Denegri
  • METHOD OF GENE TRANSFER FOR THE TREATMENT OF RECESSIVE CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA (CPVT)
    Publication number: 20140309290
    Abstract: The present invention concerns a method for the treatment of recessive Catecholaminergic Polymorphic Ventricular Tachycardia comprising delivering a gene into a cardiac cell.
    Type: Application
    Filed: June 3, 2014
    Publication date: October 16, 2014
    Applicant: Fondazione Salvatore Maugeri Clinica Del Lavoro E Della Riabilitazione (Italian Research Foundation)
    Inventors: Silvia G. PRIORI, Carlo NAPOLITANO, Marco DENEGRI
  • Method of gene transfer for the treatment of recessive catecholaminergic polymorphic ventricular tachycardia (CPVT)
    Patent number: 8859517
    Abstract: The present invention concerns a method for the treatment of recessive Catecholaminergic Polymorphic Ventricular Tachycardia comprising delivering a gene into a cardiac cell.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: October 14, 2014
    Assignee: Fondazione Salvatore Maugeri Clinica del Lavoro e Della Riabilitazione
    Inventors: Silvia G. Priori, Carlo Napolitano, Marco Denegri
  • Method of Gene Transfer for the Treatment of Recessive Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
    Publication number: 20130059905
    Abstract: The present invention concerns a method for the treatment of recessive Catecholaminergic Polymorphic Ventricular Tachycardia comprising delivering a gene into a cardiac cell.
    Type: Application
    Filed: August 8, 2012
    Publication date: March 7, 2013
    Applicants: (ITALIAN RESEARCH FOUNDATION)
    Inventors: Silvia G. Priori, Carlo Napolitano, Marco Denegri
  • CARDIAC RISK STRATIFICATION BY NOS1AP GENOTYPING
    Publication number: 20110177503
    Abstract: A risk-conferring genetic modifier is found in a large LQTS cohort. A NOS1AP tag SNP genotype provides an additional clinical assessment, which helps assess risk and choice of therapeutic strategies in LQTS as well as other conditions such as Brugada Syndrome, and catecholaminergic polymorphic ventricular tachycardia (CPTV).
    Type: Application
    Filed: December 21, 2010
    Publication date: July 21, 2011
    Inventors: Peter M. Spooner, Silvia G. Priori, Carlo Napolitano
  • Transgenic animal model for catecholaminergic polymorphic ventricular tachycardia (CPVT) and use thereof
    Patent number: 7741529
    Abstract: The present invention refers to non-human transgenic mammals, preferably rodents, or mice, which comprise a mutation in the gene encoding for the cardiac ryanodine receptor (RyR2). Transgenic animals carrying the amino acid change R4496C in the RyR2 protein show a phenotype similar to that of Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) (OMIM: 604772). Further provided are methods for using these animals as in vivo model of Catecholaminergic Polymorphic Ventricular Tachycardia and RyR2 dependent arrhythmias, in drug screening and for understanding the molecular basis of RyR2 dependent arrhythmias.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: June 22, 2010
    Inventors: Silvia G. Priori, Carlo Napolitano