Abstract: A magnetic particle imaging system that includes a magnetic field generating system with at least one magnet and providing a gradient magnetic field within an observation region such that the gradient magnetic field has a dynamic field-free region (FFR) for an object under observation having strongly-interacting magnetic particles distributed therein. The magnetic field generating system also includes a drive field and a slow shift field that dynamically shifts the FFR across a field of view (FOV) within the observation region, where the trajectory of the drive field accommodates for a coercivity of the strongly-interacting magnetic particles by ensuring that the particles in the FOV are saturated to a full coercivity field prior to traversing to an opposite-polarity of coercivity. The magnetic particle imaging system also includes a detection system proximate the observation region and configured to detect a signal from the strongly-interacting magnetic particles.

Abstract: An integrated energy absorbing system of a vehicle with a front integrated energy absorbing casting and a back integrated energy absorbing casting. Each front and back casting is a single unified casting that makes up the integrated energy absorbing system. Ribbed sections such as “I” sections and “C” sections make up the castings and are formed from a variety of different techniques and/or formings such as cutout, waveform profile, tapering, flaring and/or rib spacing. Additional sections such as closed section castings may also be integrated in the integrated energy absorbing system.

Abstract: The present disclosure provides for compositions including coated magnetic particles (e.g., coated magnetic nanoparticles), methods of using the coated magnetic particles such as imaging a subject (e.g., a mammal), tissue, organ, or the like, a cryopreservation composition including the coated magnetic particles, methods of use of the cryopreservation composition in biomaterials (e.g., tissue, organ, and the like), methods of making the composition and cryopreservation composition, and the like.

Abstract: The present invention relates to treatment of AR-related disorders by modulating the levels of AR2, which is a naturally occurring AR variant and is capable of modulating AR transcriptional activity.

Abstract: The present disclosure provides a nanoparticle comprising a positively-charged surface and an interior comprising (i) a core and (ii) at least two nucleic acid layers, wherein each nucleic acid layer is positioned between a cationic lipid bilayer. Methods of making such nanoparticles are further provided herein. Additionally, related cells, populations of cells, pharmaceutical compositions comprising the presently disclosed nanoparticles are provided. Methods of increasing an immune response against a tumor in a subject, methods of delivering RNA molecules to an intra-tumoral microenvironment, lymph node, and/or a reticuloendothelial organ in a subject, and methods of treating a subject with a disease are furthermore provided.

Abstract: A magnetic particle imaging system that includes a magnetic field generating system with at least one magnet and providing a gradient magnetic field within an observation region such that the gradient magnetic field has a dynamic field-free region (FFR) for an object under observation having strongly-interacting magnetic particles distributed therein. The magnetic field generating system also includes a drive field and a slow shift field that dynamically shifts the FFR across a field of view (FOV) within the observation region, where the trajectory of the drive field accommodates for a coercivity of the strongly-interacting magnetic particles by ensuring that the particles in the FOV are saturated to a full coercivity field prior to traversing to an opposite-polarity of coercivity. The magnetic particle imaging system also includes a detection system proximate the observation region and configured to detect a signal from the strongly-interacting magnetic particles.

Abstract: Tissue-engineered electronic peripheral nerve interface (TEENI) devices, methods of using TEENI devices, and systems using TEENI devices are provided. In particular, TEENI devices include a support member having a length, at least one thread set comprising a plurality thread set arms having a plurality of electronic leads running through the thread set arms and being fully encapsulated within the support member, and a plurality of electrodes fixed to the plurality of thread set arms.

Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, micelles (also referred to as a “magnetic composite nanocarrier” (MCNC)), methods of making micelles, methods of using micelles, and the like.

Abstract: The present disclosure provides for compositions of magnetic nanoparticles and methods of making magnetic nano-particles with large magnetic diameters.

Abstract: The present disclosure provides magnetically templated tissue scaffolds, methods of making the magnetically templated tissue scaffolds, and various methods of employing the scaffolds for tissue growth and repair in vitro and in vivo, including peripheral nerve repair.

Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, micelles (also referred to as a “magnetic composite nanocarrier” (MC-NC)), methods of making micelles, methods of using micelles, and the like.

Abstract: Disclosed are various embodiments for a system configured to characterize a magnetic response of a sample. The system can comprise an electrical source configured to generate a time-varying current supply, an excitation coil system coupled to the electrical source to generate a time-vary magnetic field for application to a sample, and a sensing coil system that senses a magnetic response of the sample in response to the time-varying magnetic field. The sensing coil system can comprise a pick-up coil and a balancing coil that can be translated or rotated. The balancing coil configured to cancel a feed-through induction signal. In another embodiment, the sensing coil system can comprise an adjustable fine-tuning coil that is configured to modify an effect of the cancellation of the feed-through induction signal.

Abstract: Disclosed are various embodiments for a system configured to characterize a magnetic response of a sample. The system can comprise an electrical source configured to generate a time-varying current supply, an excitation coil system coupled to the electrical source to generate a time-vary magnetic field for application to a sample, and a sensing coil system that senses a magnetic response of the sample in response to the time-varying magnetic field. The sensing coil system can comprise a pick-up coil and a balancing coil that can be translated or rotated. The balancing coil configured to cancel a feed-through induction signal. In another embodiment, the sensing coil system can comprise an adjustable fine-tuning coil that is configured to modify an effect of the cancellation of the feed-through induction signal.

Abstract: The present disclosure provides for compositions of magnetic nanoparticles and methods of making magnetic nano-particles with large magnetic diameters.

Abstract: Tissue-engineered electronic peripheral nerve interface (TEENI) devices, methods of using TEENI devices, and systems using TEENI devices are provided. In particular, TEENI devices include a support member having a length, at least one thread set comprising a plurality thread set arms having a plurality of electronic leads running through the thread set arms and being fully encapsulated within the support member, and a plurality of electrodes fixed to the plurality of thread set arms.