Patents by Inventor Carlo Traverso

Carlo Traverso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENDOVASCULAR INJECTABLE STENTS FOR CARDIOVASCULAR DRUG DELIVERY
    Publication number: 20230293159
    Abstract: Herein is described a stent platform capable of intravascular local delivery of therapeutics through multipoint injection of drug agents into the vascular walls and endocardial surfaces. More specifically, an endovascular injectable stent made of kirigami skin is wrapped around a soft linear actuator and used for intravascular local drug delivery of therapeutics. This platform addresses an unmet need of treating aortic stenosis and atherosclerotic cardiovascular disease.
    Type: Application
    Filed: June 21, 2021
    Publication date: September 21, 2023
    Inventors: Sahab BABAEE, Mazen ALBAGHDADI, Mohammed CHOWDHURY, Carlo TRAVERSO
  • Poly(Beta-Thioester) Polymers and Polymeric Nanoparticles
    Publication number: 20220175938
    Abstract: The disclosure describes poly(?-thioester) polymers and polymeric nanoparticles, pharmaceutical compositions comprising these materials, their use in the treatment of cancer and infectious disease, and machine learning methods for identifying and selecting them.
    Type: Application
    Filed: July 31, 2020
    Publication date: June 9, 2022
    Inventors: ROBERT LANGER, CARLO TRAVERSO, AMEYA KIRTANE, DANIEL REKER, LEWIS SCOTT JONES, HYUNJOON KIM, NETRA RAJESH
  • KIRIGAMI-INSPIRED STENTS FOR SUSTAINED LOCAL DELIVERY OF THERAPEUTICS
    Publication number: 20210393422
    Abstract: The present disclosure provides a kirigami-inspired injectable stent system. The stent systems and methods enable radial/circumferential and longitudinal delivery of an extended release of therapeutics within tubular structures of the body, such as the GI tract and trachea. According to some aspects, a kirigami-based injectable stent system is provided that can enable drug release through deposition of therapeutic-coated needles of the stent in the tubular mucosa, such as often found in the gastrointestinal tract or trachea.
    Type: Application
    Filed: June 21, 2021
    Publication date: December 23, 2021
    Inventors: Sahab BABAEE, Yichao SHI, Saeed ABBASALIZADEH, Robert LANGER, Carlo TRAVERSO
  • METHODS OF AVOIDING EXCIPIENT-BASED ADVERSE EFFECTS AND OF EXPLOITING BIOLOGICAL PROPERTIES OF GRAS COMPOUNDS
    Publication number: 20200297671
    Abstract: This invention relates to methods of selecting or tailoring a therapeutic for an individual subject, reducing the excipient burden in a subject, and identifying adverse reaction-associated inactive ingredients in a subject being administered multiple drugs. The invention also relates to methods of inhibiting UGT2B7 activity or P-gp activity, methods of treating a subject via co-administration of a UGT2B7 inhibitor or a P-gp inhibitor, and pharmaceutical compositions comprising gum rosin, abietic acid, or vitamin A palmate.
    Type: Application
    Filed: February 27, 2020
    Publication date: September 24, 2020
    Inventors: ROBERT LANGER, CARLO TRAVERSO, DANIEL REKER, STEVEN BLUM
  • Digital amplification for detection of mismatch repair deficient tumor cells
    Publication number: 20060019277
    Abstract: The detection of mutations in fecal DNA represents a promising, non-invasive approach for detecting colorectal cancers in average risk populations. One of the first practical applications of this technology involves the examination of microsatellite markers to sporadic cancers with mismatch repair deficiencies. As such cancers nearly always occur in the proximal colon, this test is useful as an adjunct to sigmoidoscopy, which detects only distal colorectal lesions.
    Type: Application
    Filed: May 27, 2005
    Publication date: January 26, 2006
    Applicant: The Johns Hopkins University
    Inventors: Carlo Traverso, Kenneth Kinzler, Bert Vogelstein
  • Tube coupler, particularly suitable for platform foundation piles
    Patent number: 4641984
    Abstract: A tube coupler consisting of a tube piece cut longitudinally and provided internally with two pairs of double-acting hydraulic cylinder-piston units hinged to the wall of the tube piece and each acting on two connecting rods which are hinged to said wall on opposite sides of the longitudinal cut. The tube piece is also provided with two sets of longitudinal spacer members on its outer surface and with frusto-conical endpieces at its extremities.
    Type: Grant
    Filed: September 30, 1985
    Date of Patent: February 10, 1987
    Assignee: 501 Saipem S.p.A.
    Inventors: Giuseppe Cianci, Carlo Traverso