Abstract: An analyzer configured to monitor a radio access network (RAN) of a cellular network is provided. The RAN includes multiple clusters that each includes multiple sites and multiple cells. The analyzer receives a multiple key performance indicator (KPI) measurements from the multiple clusters. Each KPI measurements generated for one of several KPI types. The analyzer receives information identifying anomalous KPI measurements in the received KPI measurements. For a cluster of the RAN, the analyzer identifies one or more common anomalous KPI types that satisfy a ubiquity criterion. The analyzer ranks the identified common anomalous KPI types for the cluster based on an anomaly metric that is derived from the anomalous KPI measurements generated for each identified common anomalous KPI type. The analyzer outputs a list of common anomalous KPI types for the cluster based on the ranking.

Abstract: An analyzer configured to monitor a radio access network (RAN) of a cellular network is provided. The RAN includes multiple clusters that each includes multiple sites and multiple cells. The analyzer receives a multiple key performance indicator (KPI) measurements from the multiple clusters. Each KPI measurements generated for one of several KPI types. The analyzer receives information identifying anomalous KPI measurements in the received KPI measurements. For a cluster of the RAN, the analyzer identifies one or more common anomalous KPI types that satisfy a ubiquity criterion. The analyzer ranks the identified common anomalous KPI types for the cluster based on an anomaly metric that is derived from the anomalous KPI measurements generated for each identified common anomalous KPI type. The analyzer outputs a list of common anomalous KPI types for the cluster based on the ranking.

Abstract: The invention relates to a process for preparing a non-expanded tissue derivative, that is not subjected to cell proliferation in vitro, comprising a vascular-stromal fraction enriched in stem and multipotent elements, such as pericytes and/or mesenchymal stem cells, or for preparing non-embryonic stem cells obtained from a tissue sample or from said derivative, wherein said tissue derivatives or said cells are subjected to vibrations derived from a heart sound such to control the degree of differentiation or possible differentiation of said stem and multipotent elements into several other types of cells that is to optimize their potency. The invention relates also to a device for carrying out said process, to stem cells obtainable by the process as well as a drug for the regeneration of an animal tissue.

Abstract: Methods of acquiring cellular and tissue vibrational patterning to identify signatures capable to induce pluripotency and commitment towards defined lineages, as well as survival under hostile conditions (i.e. oxidative stress) in both human adult stem cells and human adult somatic cells are described. Specifically, the invention relates to the delivery of such signatures to human adult stem cells or human adult somatic cells to induce specific differentiation processes and promote survival to hostile environmental conditions. Further methods are described of targeting tissue resident in vivo to retrieve their ability to sustain self-healing process, therefore affording a Regenerative Medicine executed without the needs for (stem) cell or tissue transplantation.

Abstract: An implantable medical device may include a coating layer that includes a nanostructured hydroxyapatite doped with zinc ions and functionalized with lactoferrin. A process for coating an implantable medical device may include: providing an electrolytic bath; immersing a cathode and an anode in the electrolytic bath, the cathode including the implantable medical device; and allowing direct electric current to pass through the electrolytic bath so as to obtain electrolytic deposition on the implantable medical device of nanostructured hydroxyapatite doped with zinc ions. The electrolytic bath may include calcium ions, phosphate ions, and the zinc ions. The electrolytic bath also may include lactoferrin. The process may further include depositing lactoferrin on the implantable medical device coated with the nanostructured hydroxyapatite doped with the zinc ions.

Abstract: The invention relates to a process for preparing a non-expanded tissue derivative, that is not subjected to cell proliferation in vitro, comprising a vascular-stromal fraction enriched in stem and multipotent elements, such as pericytes and/or mesenchymal stem cells, or for preparing non-embryonic stem cells obtained from a tissue sample or from said derivative, wherein said tissue derivatives or said cells are subjected to vibrations derived from a heart sound such to control the degree of differentiation or possible differentiation of said stem and multipotent elements into several other types of cells that is to optimize their potency. The invention relates also to a device for carrying out said process, to stem cells obtainable by the process as well as a drug for the regeneration of an animal tissue.

Abstract: Chemical preconditioning process for cell material to obtain chemical epigenetic reprogramming and pluripotency expression of stem and multipotent elements of non-embryonic origin, such as pericytes and/or mesenchymal stem cells, and/or adult somatic cells. The process includes the step of subjecting a non-expanded tissue derivative having the stem and multipotent elements, and/or of subjecting non-embryonic stem cells and/or non-embryonic somatic cells, obtained from a tissue sample or from the derivative, to a mixing with hyaluronic acid esterified with butyric and retinoic acids (HBR).

Abstract: The invention relates to a process for preparing a non-expanded tissue derivative, that is not subjected to cell proliferation in vitro, which has a vascular-stromal fraction enriched in stem and multipotent elements, such as pericytes and/or mesenchymal stem cells, or for preparing non-embryonic stem cells obtained from a tissue sample or from such tissue derivative, wherein the tissue derivative or such cells are subjected to vibrations derived from a heart sound to control the degree of differentiation or possible differentiation of the stem and multipotent elements into several other types of cells and optimize their potency. The invention relates also to a device for carrying out the process, to stem cells obtainable by the process as well as a drug for the regeneration of an animal tissue.

Abstract: The present the invention relates to a new use of retinoic of hyaluronic acid, that exhibit pre-differentiating activity on totipotent stem cells. The invention also relates to a process to differentiate said stem cells and to select molecules capable of modulating the pro-differentiating activity of those esters.