Abstract: A knock-in non-human mammal comprising a recombinant androgen receptor (AR) cassette containing an exogenous human polyglutamine (polyQ) tract encoding sequence in exon 1, wherein the human polyQ tract encoding sequence is stably integrated into the genome of the animal. Also provided are recombinant cells, fertilized eggs and tissues. The resulting animal displays a wide range of phenotypes, best characterized as Metabolic Syndrome and can be used in screening and other assays.

Abstract: A knock-in non-human mammal comprising a recombinant androgen receptor (AR) cassette containing an exogenous human polyglutamine (polyQ) tract encoding sequence in exon 1, wherein the human polyQ tract encoding sequence is stably integrated into the genome of the animal. Also provided are recombinant cells, fertilized eggs and tissues. The resulting animal displays a wide range of phenotypes, best characterized as Metabolic Syndrome and can be used in screening and other assays.

Abstract: A multicore fiber-to-single core fiber adapting device, also referred a fan-in/fan-out (FIFO) device. More specifically, an optical fiber system comprising a multicore fiber, a tapered glass device that it is configured to connect a multicore fiber to a multiple single core fiber, and/or single mode fibers, advantageously having one or more protective layers to protect the tapered device. Associated methods of manufacture.

Abstract: Apparatus and methods for mitigating transverse mode instabilities (TMI) in high power fiber amplifiers that does not depend on active feedback loops. The apparatus and method involve the modulation of the amplitude and/or phase of selected spatial mode components of an input signal beam to increase the TMI threshold of the amplifier. Once the desired modal adjustments are made, the beam is input to a mode multiplexer whereupon an optimized output beam can be input to the active fiber of the amplifier system. By increasing the TMI threshold of the amplifier, the amplifier can be operated at higher power before TMI sets in. A control stage of the fiber amplifier system includes (a) a (seed) beam splitting section; (b) an amplitude and phase control component; and (c) a mode multiplexer that maps multiple individual signal beams to different fiber modes.

Abstract: In one aspect, a temperature sensing assembly for measuring temperature of a surface of a structure includes a thermocouple device and a docking device. The thermocouple device includes a temperature sensing junction point disposed within an elongate sheath to measure the temperature of the surface of the structure at a desired location. The thermocouple device further comprises a contact portion configured to contact the surface of the structure. The docking device has a bottom surface to attach to the surface of the structure adjacent the desired location. A line extends through the center of the sheath and the sheath has a cross-sectional area in a plane perpendicular to the line. The contact portion is configured such that, when the docking device is coupled to the surface, an area of contact between the contact portion and the surface of the structure is greater than the cross-sectional area of the sheath.

Abstract: In one aspect, a temperature sensing assembly for measuring temperature of a surface of a structure includes a thermocouple device and a docking device. The thermocouple device includes a temperature sensing junction point disposed within an elongate sheath to measure the temperature of the surface of the structure at a desired location. The thermocouple device further comprises a contact portion configured to contact the surface of the structure. The docking device has a bottom surface to attach to the surface of the structure adjacent the desired location. A line extends through the center of the sheath and the sheath has a cross-sectional area in a plane perpendicular to the line. The contact portion is configured such that, when the docking device is coupled to the surface, an area of contact between the contact portion and the surface of the structure is greater than the cross-sectional area of the sheath.

Abstract: A temperature sensing assembly for measuring the temperature of an inner wall of a high temperature vessel includes a thermocouple assembly having multiple junction points to provide indications of temperature. The assembly further includes support structures for supporting the thermocouple assembly in the interior space of the vessel and to maintain the junction points proximate the inner wall of the vessel.

Abstract: A new method for the treatment of ocular disease and injury is provided. The method involves the administration of a biocompatible implant, the porcine small intestinal serosa (or serous membrane), as graft/patch directly to the eye, for inducing restoration, remodeling, and repair of a tissue in a variety of injuries or conditions in the cornea, conjunctiva, and/or the eyelid due to trauma, diseases, or surgery. A focus on product interactions, safety profile has been fully defined and the membrane is reasonable in process, easy and convenient to prepare and significant in therapeutic effect. A simple standardized and straightforward method has been developed to fabricate this ultra-thin, delicate, and transparent material. Derived from well-defined mechanical strength, the serous membrane demonstrates consistency and flexibility that provides agile solutions for the physician.

Abstract: A temperature sensing assembly for measuring the temperature of an inner wall of a high temperature vessel includes a thermocouple assembly having multiple junction points to provide indications of temperature. The assembly further includes support structures for supporting the thermocouple assembly in the interior space of the vessel and to maintain the junction points proximate the inner wall of the vessel.

Abstract: This invention relates to a surgical or medical dressing which comprises a supporting and reinforcing layer of elastomeric material (as polyethylene homopolymer) embedded in the composition of honey/additives, to supplement the mechanical strength, which would be fabricated as a single integral piece, intended to provide multi-functional properties in the wound environment, particularly for promote or expedite the regeneration or repair deep tissue injuries or chronic wounds such as ulcers. Several additional characteristics of this new dressing provide an advantage to any wound care product developed from it. First, the biomaterial retains many biological properties of its major constituents (honey/additives). Second, the application of this safety dressing is greatly simplified particularly for pediatric burn Care.

Abstract: A new method for the treatment of ocular disease and injury are provided. The methods involve the administration of a biocompatible implant, the porcine small intestinal serosa (or serous membrane), as graft/patch directly to the eye, for inducing restoration, remodeling, and repair of a tissue in a variety of injuries or conditions in the cornea, conjunctiva, and/or the eyelid due to trauma, diseases, or surgery. A focus on graft interactions, safety profile has been fully defined and the membrane is reasonable in process, easy and convenient to prepare and significant in therapeutic effect. A simple standardized and straightforward method it has been developed to fabricate this ultra-thin, delicate, and transparent material. Derived from well-defined mechanical strength, the graft demonstrates consistency and flexibility than provides agile solutions for the Physician.

Abstract: A temperature sensing assembly for measuring the temperature of an inner wall of a high temperature vessel includes a thermocouple assembly having multiple junction points to provide indications of temperature. The assembly further includes support structures for supporting the thermocouple assembly in the interior space of the vessel and to maintain the junction points proximate the inner wall of the vessel.

Abstract: A three-dimensional (3-D) orthopedic drill guide device for accommodating a bone drill during an orthopedic surgery is disclosed. By establishing two specific angles in relation to the bone fascia, the device acts as a guide for bone drilling locations. In one specific instance, it is an optimal 3-D drill guide for the direction and Gamma angle (resulting from the devices Alpha and Beta angles of the device) of a drill hole in a femoral bone when used to replace an injured anterior cruciate ligament (ACL).

Abstract: A bionanofluid includes a carbon-based nanomaterial substantially mono-dispersed in a fluid. The carbon-based nanomaterial is surface modified with a polar group when the fluid is polar or with a non-polar group when the fluid is non-polar, and functionalized with a biological targeting moiety to allow specific association of the carbon-based nanomaterial to a targeted entity. A hybrid bionanofluid includes the bionanofluid, with the carbon-based nanomaterial further modified with a hybrid nanoparticle which includes an alloy, transition metal, semi-conductor, semi-metal or polymer based nanoparticle with biological targeting moiety. A hydrogel, foam, cream, spray or dried product includes the bionanofluid or hybrid bionanofluid. The bionanofluid or hybrid bionanofluid are useful in multimodal imaging (photo-luminescence, luminescence, photo-acoustic, MRI, ultrasound) and/or cellular targeting.

Abstract: A knock-in non-human mammal comprising a recombinant androgen receptor (AR) cassette containing an exogenous human polyglutamine (polyQ) tract encoding sequence in exon 1, wherein the human polyQ tract encoding sequence is stably integrated into the genome of the animal. Also provided are recombinant cells, fertilized eggs and tissues. The resulting animal displays a wide range of phenotypes, best characterized as Metabolic Syndrome and can be used in screening and other assays.

Abstract: A three-dimensional (3-D) orthopedic drill guide device for accommodating a bone drill during an orthopedic surgery is disclosed. By establishing two specific angles in relation to the bone fascia, the device acts as a guide for bone drilling locations. In one specific instance, it is an optimal 3-D drill guide for the direction and Gamma angle (resulting from the devices Alpha and Beta angles of the device) of a drill hole in a femoral bone when used to replace an injured anterior cruciate ligament (ACL).

Abstract: A method for boosting the efficiency of chlorine dioxide production in a chemical facility. A chloride donor is introduced into a feed of sulfuric acid or a reducing agent, both of which are injected into the recirculation lines, or other areas, of a chlorine dioxide producing facility. The chloride donor provides the intermediate chemical species necessary for the efficient generation of chlorine dioxide at high acidities and/or the high local acidity in the wake zone of the acid injection location, thereby enabling greater efficiency in the reduction of chlorine dioxide from sodium chlorate.

Abstract: A temperature sensing assembly for measuring the temperature of an inner wall of a high temperature vessel includes a thermocouple assembly having multiple junction points to provide indications of temperature. The assembly further includes support structures for supporting the thermocouple assembly in the interior space of the vessel and to maintain the junction points proximate the inner wall of the vessel.

Abstract: The present invention relates to a biologically active graft (BAG) composition and methods for its preparation and use. More particularly, it details a method for preparing a non-immunogenic tissue graft composition comprising esophagus mucosa, basement membrane and tunica submucosa as intact natural sheet forms (Ad integrum), delaminated from the tunica muscularis and adventitia of an esophagus of a warm-blooded vertebrate. The composition is capable of serving as a substitute for skin autograft for skin replacement therapy and induces stromal cells regeneration when implanted in warm-blooded vertebrate including human subjects.

Abstract: A practical active dressing (PAD) is disclosed that includes a honey-based composition which is to be applied to a patient's wound. Additionally a method of manufacturing a practical active dressing is disclosed. The formulation, with considerable wound and ulcer healing capacity and strong antimicrobial activity, incorporate the combination of active ingredients of ripe honey, gelling agents, plant extracts and chemical compounds.