Patents by Inventor Carlos A. Guzman

Carlos A. Guzman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240058438
    Abstract: The present disclosure provides immunogenic compositions comprising: a) hepatitis C virus (HCV) E1E2 heterodimers, HCV E2, or HCV E1; and b) an adjuvant, where the adjuvant is a cyclic dinucleotide or an archaeosome. The present disclosure provides methods of inducing an immune response in an individual to HCV, the methods comprising administering to an individual an effective amount of an immunogenic composition of the present disclosure.
    Type: Application
    Filed: January 19, 2023
    Publication date: February 22, 2024
    Inventors: Michael Houghton, Abdolamir Landi, Carlos A. Guzman, Thomas Ebensen, Darren Hockman, John L. Law, Michael Logan
  • Publication number: 20230129118
    Abstract: Phytosphingosine derivatives suitable as adjuvants in immune stimulation, pharmaceutical compositions comprising such compounds and the medical use of the compounds and/or compositions in therapeutic or prophylactic methods of immune stimulation in a subject, and for use in the treatment of a disease, for which stimulation of an immune response in a subject produces a therapeutic benefit. The phytosphingosine derivative may also be used as adjuvants in vaccinating a subject. The phytosphingosine derivative may also be used in stimulating antibody production, stimulating an immune response against infection, stimulating an immune response against a cancer, or preventing and/or treating septic shock. Methods for the manufacture of the derivatives comprising an Ugi-4-component reaction (Ugi-4CR) is also disclosed.
    Type: Application
    Filed: June 18, 2021
    Publication date: April 27, 2023
    Inventors: Yanira MENDEZ-GOMEZ, Bernhard WESTERMANN, Daniel GARCIA-RIVERA, Aldrin VASCO-VIDAL, Ludger WESSJOHANN, Carlos A. GUZMÁN, Thomas EBENSEN, Kai SCHULZE, Peggy RIESE, Stephanie TRITTEL
  • Patent number: 11593044
    Abstract: According to examples, an apparatus may include a processor and a memory on which is stored instructions that when executed by the processor, cause the processor to determine that data stored in a memory device of a printer cartridge installed in a printing device is to be updated. The printing device may be in remote communication with the apparatus via a network connection. The instructions may also cause the processor to identify update data that is to be used to update the data stored in the memory device. The instructions may further cause the processor to communicate, via the network connection with the printing device, the identified update data to the printing device. The printing device may update the data stored in the memory device of the printer cartridge with the update data.
    Type: Grant
    Filed: December 8, 2021
    Date of Patent: February 28, 2023
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Gabriel Scott McDaniel, Paul L Jeran, Juan Carlos Guzman, George Henry Kerby, Katelyn Christene Morse
  • Patent number: 11576968
    Abstract: The present disclosure provides immunogenic compositions comprising: a) hepatitis C virus (HCV) E1E2 heterodimers, HCV E2, or HCV E1; and b) an adjuvant, where the adjuvant is a cyclic dinucleotide or an archaeosome. The present disclosure provides methods of inducing an immune response in an individual to HCV, the methods comprising administering to an individual an effective amount of an immunogenic composition of the present disclosure.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: February 14, 2023
    Assignee: The Governors of the University of Alberta
    Inventors: Michael Houghton, Abdolamir Landi, Carlos A. Guzman, Thomas Ebensen, Darren Hockman, John L. Law, Michael Logan
  • Publication number: 20220266549
    Abstract: A panel is disclosed, including a first facesheet, a second face sheet, and a plurality of pultrusion-formed web structures. Each web structure has a middle support portion, a first end portion, and a second end portion. The first end portion of each web structure is attached to the first facesheet and the second end portion of each web structure is attached to the second facesheet. The middle support portion, first end portion, and second end portion of each web structure form a single monolithic structure.
    Type: Application
    Filed: May 12, 2022
    Publication date: August 25, 2022
    Applicant: The Boeing Company
    Inventors: Michael Leslie Hand, Juan Carlos Guzman
  • Publication number: 20220257752
    Abstract: In a first aspect, the present invention relates to cyclic dinucleotide compounds, in particular, c-di AMP for use in a method of inducing or promoting an immune response in an individual wherein said individual is a neonate or infant. The compound according to the present invention is particularly useful for use in therapeutic or prophylactic vaccination. In a further aspect, pharmaceutical compositions comprising the compound according to the present invention as an adjuvant, a pharmaceutically active ingredient for use as defined herein, in particular, as an adjuvant in a vaccine for unborn children, neonates and infants are provided. Finally, the present invention relates to a kit comprising a compound according to the present invention as an adjuvant, an antigen comprising antigenic structure as active vaccination component, in particular, to the use of said kit in a use of preventing or treating a disease.
    Type: Application
    Filed: August 28, 2020
    Publication date: August 18, 2022
    Inventors: Carlos A. GUZMAN, Dario LIRUSSI, Thomas EBENSEN, Sebastian Felix WEISSMANN
  • Publication number: 20220258600
    Abstract: A composite tank for a reusable launch vehicle comprises a composite wall, having a first coefficient of thermal expansion. The composite wall comprises a first end, a second end, a central axis, which passes through the first end and through the second end, and a cylindrical interior surface. The composite tank also comprises slosh baffles, formed from a second material, having a second coefficient of thermal expansion that is different from the first coefficient of thermal expansion. Each of the slosh baffles is attached to the cylindrical interior surface of the composite wall. Each of the slosh baffles is annular and is separated from the cylindrical interior surface of the composite wall by a radial gap, selected, in part, based on a difference between the first coefficient of thermal expansion and the second coefficient of thermal expansion. The radial gap is configured to change responsive to changes in temperature of the composite tank.
    Type: Application
    Filed: August 18, 2021
    Publication date: August 18, 2022
    Applicant: The Boeing Company
    Inventors: Jonathan David Embler, John Matthew Nichols, Glenn William Torres, Jacob Ryan Szczudlak, William Preston Keith, Tin Anh Luu, Morgan Ashley Lewis, Keith Charles Kreutztrager, Jonathan Edward Toomey, Juan Carlos Guzman
  • Patent number: 11364691
    Abstract: A panel is disclosed, including a first facesheet, a second face sheet, and a plurality of pultrusion-formed web structures. Each web structure has a middle support portion, a first end portion, and a second end portion. The first end portion of each web structure is attached to the first facesheet and the second end portion of each web structure is attached to the second facesheet. The middle support portion, first end portion, and second end portion of each web structure form a single monolithic structure.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: June 21, 2022
    Assignee: The Boeing Company
    Inventors: Michael Leslie Hand, Juan Carlos Guzman
  • Publication number: 20210170018
    Abstract: The present disclosure provides immunogenic compositions comprising: a) hepatitis C virus (HCV) E1E2 heterodimers, HCV E2, or HCV E1; and b) an adjuvant, where the adjuvant is a cyclic dinucleotide or an archaeosome. The present disclosure provides methods of inducing an immune response in an individual to HCV, the methods comprising administering to an individual an effective amount of an immunogenic composition of the present disclosure.
    Type: Application
    Filed: December 15, 2020
    Publication date: June 10, 2021
    Inventors: Michael Houghton, Abdolamir Landi, Carlos A. Guzman, Thomas Ebensen, Darren Hockman, John L. Law, Michael Logan
  • Publication number: 20210138745
    Abstract: A panel is disclosed, including a first facesheet, a second face sheet, and a plurality of pultrusion-formed web structures. Each web structure has a middle support portion, a first end portion, and a second end portion. The first end portion of each web structure is attached to the first facesheet and the second end portion of each web structure is attached to the second facesheet. The middle support portion, first end portion, and second end portion of each web structure form a single monolithic structure.
    Type: Application
    Filed: November 13, 2019
    Publication date: May 13, 2021
    Applicant: The Boeing Company
    Inventors: Michael Leslie Hand, Juan Carlos Guzman
  • Publication number: 20210030865
    Abstract: In a first aspect, the present invention relates to a method for determining the responsiveness of an individual to vaccination, like viral vaccination or for the determination of viral vaccine efficacy in an individual as well as a method for the stratification of the vaccination regimen, e.g. viral vaccination, in an individual based on determining the level or the amount of at least one of IL-8 or IL-18 in a sample; said sample is obtained from an individual at least once before or at least once after vaccination. The method allows to determine the vaccination regimen with the vaccine, in particular, a virus vaccine, like an influenza virus vaccine whereby when a low level of at least one of IL-8 and/or IL-18 is determined, said low level is indicative for a personalized vaccine strategy. In a further aspect, the use of at least one of IL-8 or IL-18 as a predictive marker for vaccine efficacy or immune protection by vaccination is provided.
    Type: Application
    Filed: March 20, 2019
    Publication date: February 4, 2021
    Inventors: Carlos A. GUZMAN, Frank PESSLER, Peggy RIESE, Manas AKMATOV
  • Patent number: 10881726
    Abstract: The present disclosure provides immunogenic compositions comprising: a) hepatitis C virus (HCV) E1E2 heterodimers, HCV E2, or HCV E1; and b) an adjuvant, where the adjuvant is a cyclic dinucleotide or an archaeosome. The present disclosure provides methods of inducing an immune response in an individual to HCV, the methods comprising administering to an individual an effective amount of an immunogenic composition of the present disclosure.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: January 5, 2021
    Assignees: The Governors of the University of Alberta, Helmholtz Center for Infection Research
    Inventors: Michael Houghton, Abdolamir Landi, Carlos A. Guzman, Thomas Ebensen, Darren Hockman, John L. Law, Michael Logan
  • Patent number: 10279550
    Abstract: A method for assembling a composite wall assembly edge joint including laying up a first composite face sheet, laying up a first composite buildup pad having a first tapered section onto the first composite face sheet and positioning a composite flute core member, including a tapered first portion with a first inclined surface and a second inclined surface. First inclined surface is positioned onto the first tapered section of the first composite buildup pad and a second portion of the composite flute core member extends from the tapered first portion along first composite face sheet. The method also includes laying up a second composite buildup pad having a second tapered section with the second composite buildup pad spaced apart from the first composite buildup pad and having at least a portion of the second tapered section overlying the second inclined surface of the tapered first portion.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: May 7, 2019
    Assignee: THE BOEING COMPANY
    Inventors: Juan Carlos Guzman, Michael Leslie Hand, Douglas McCarville
  • Patent number: 10279572
    Abstract: A hybrid softening strip for controlling stresses in a joint at low temperatures includes a layer of sacrificial material that can be tailored to fit the softening strip in the joint after the softening strip has been bonded to a structure.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: May 7, 2019
    Assignee: The Boeing Company
    Inventors: Juan Carlos Guzman, Douglas A. McCarville, Michael Leslie Hand, Michael James Robinson
  • Patent number: 10173406
    Abstract: A composite wall assembly edge joint including a first composite buildup pad having a first tapered section is secured to and extends along a first composite face sheet. A second composite buildup pad having a second tapered section is secured to and extends along a second composite face sheet, wherein the first and second composite buildup pads are positioned between spaced apart first and second composite face sheets. A composite flute core member includes a tapered first portion positioned between and secured to the first tapered section and to the second tapered section. A second portion of the composite flute core member extends in a direction away from the tapered first portion of the composite flute core member and is positioned between, extends along and is secured to the first and second composite face sheets.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: January 8, 2019
    Assignee: THE BOEING COMPANY
    Inventors: Juan Carlos Guzman, Michael Leslie Hand, Douglas McCarville
  • Patent number: 10138627
    Abstract: A composite wall assembly edge joint, includes a first composite buildup pad secured to a first composite face sheet with the first composite buildup pad having a first tapered section with a first inclined surface which extends in a first direction and having a second section which extends from the first tapered section with a second surface which extends in a second direction, different from the first direction, toward a first end of the first composite face sheet. The assembly further includes a composite flute core member, having a tapered first portion secured to the first tapered section; a second portion secured to the first composite face sheet; and a third portion which extends in the second direction, away from the tapered first portion, toward the first end of the first composite face sheet secured to the second section.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: November 27, 2018
    Assignee: THE BOEING COMPANY
    Inventors: Douglas McCarville, Juan Carlos Guzman, Michael Leslie Hand, Jordan O. Birkland, Alexandra K. Dillon
  • Publication number: 20180229453
    Abstract: A method for assembling a composite wall assembly edge joint including laying up a first composite face sheet, laying up a first composite buildup pad having a first tapered section onto the first composite face sheet and positioning a composite flute core member, including a tapered first portion with a first inclined surface and a second inclined surface. First inclined surface is positioned onto the first tapered section of the first composite buildup pad and a second portion of the composite flute core member extends from the tapered first portion along first composite face sheet. The method also includes laying up a second composite buildup pad having a second tapered section with the second composite buildup pad spaced apart from the first composite buildup pad and having at least a portion of the second tapered section overlying the second inclined surface of the tapered first portion.
    Type: Application
    Filed: March 24, 2017
    Publication date: August 16, 2018
    Inventors: Juan Carlos Guzman, Michael Leslie Hand, Douglas McCarville
  • Publication number: 20180229489
    Abstract: A composite wall assembly edge joint including a first composite buildup pad having a first tapered section is secured to and extends along a first composite face sheet. A second composite buildup pad having a second tapered section is secured to and extends along a second composite face sheet, wherein the first and second composite buildup pads are positioned between spaced apart first and second composite face sheets. A composite flute core member includes a tapered first portion positioned between and secured to the first tapered section and to the second tapered section. A second portion of the composite flute core member extends in a direction away from the tapered first portion of the composite flute core member and is positioned between, extends along and is secured to the first and second composite face sheets.
    Type: Application
    Filed: February 14, 2017
    Publication date: August 16, 2018
    Inventors: Juan Carlos Guzman, Michael Leslie Hand, Douglas McCarville
  • Publication number: 20180230693
    Abstract: A composite wall assembly edge joint, includes a first composite buildup pad secured to a first composite face sheet with the first composite buildup pad having a first tapered section with a first inclined surface which extends in a first direction and having a second section which extends from the first tapered section with a second surface which extends in a second direction, different from the first direction, toward a first end of the first composite face sheet. The assembly further includes a composite flute core member, having a tapered first portion secured to the first tapered section; a second portion secured to the first composite face sheet; and a third portion which extends in the second direction, away from the tapered first portion, toward the first end of the first composite face sheet secured to the second section.
    Type: Application
    Filed: June 5, 2017
    Publication date: August 16, 2018
    Inventors: Douglas McCarville, Juan Carlos Guzman, Michael Leslie Hand, Jordan O. Birkland, Alexandra K. Dillon
  • Patent number: 9902406
    Abstract: Contemplated ladder assemblies include: a) at least two rails, b) at least one step, wherein each step is coupled to the at least two rails, such that the rails are relatively vertical and the steps are relatively horizontal, c) at least one grappling footing peg, wherein the peg is operationally coupled with a rail, d) at least one safety handle, wherein the handle is coupled with at least one rail, and e) at least one commuter train, passenger train or railway car coupling fixture, wherein the coupling fixture operationally engages with a mating fixture on the commuter train, passenger train or railway car.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: February 27, 2018
    Inventors: Carlos Guzman, John Guzman