Patents by Inventor Carlos A. RAMIREZ

Carlos A. RAMIREZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12270798
    Abstract: Improved systems and methods for laboratory instrument calibration. A laboratory instrument retrieves a number of sets of past quality control parameters from a data structure. Each set includes a recovered value and a timestamp. The recovered value is equal to an output value adjusted by an initial calibration factor. The laboratory instrument determines that the number of sets is greater than a threshold and that each of the past quality control parameters has a timestamp that is within a time threshold. The laboratory instrument computes an updated calibration factor such that when the updated calibration factor is applied to a representative value of the recovered values, the representative value equals the expected recovered value. The instrument updates the data structure with the calibration factor such that the calibration factor is used in subsequent testing of patient specimens.
    Type: Grant
    Filed: November 8, 2023
    Date of Patent: April 8, 2025
    Assignee: Beckman Coulter, Inc.
    Inventor: Carlos A. Ramirez
  • Publication number: 20240142416
    Abstract: Improved systems and methods for laboratory instrument calibration. A laboratory instrument retrieves a number of sets of past quality control parameters from a data structure. Each set includes a recovered value and a timestamp. The recovered value is equal to an output value adjusted by an initial calibration factor. The laboratory instrument determines that the number of sets is greater than a threshold and that each of the past quality control parameters has a timestamp that is within a time threshold. The laboratory instrument computes an updated calibration factor such that when the updated calibration factor is applied to a representative value of the recovered values, the representative value equals the expected recovered value. The instrument updates the data structure with the calibration factor such that the calibration factor is used in subsequent testing of patient specimens.
    Type: Application
    Filed: November 8, 2023
    Publication date: May 2, 2024
    Inventor: Carlos A. Ramirez
  • Patent number: 11846616
    Abstract: Improved systems and methods for laboratory instrument calibration. A laboratory instrument retrieves a number of sets of past quality control parameters from a data structure. Each set includes a recovered value and a timestamp. The recovered value is equal to an output value adjusted by an initial calibration factor. The laboratory instrument determines that the number of sets is greater than a threshold and that each of the past quality control parameters has a timestamp that is within a time threshold. The laboratory instrument computes an updated calibration factor such that when the updated calibration factor is applied to a representative value of the recovered values, the representative value equals the expected recovered value. The instrument updates the data structure with the calibration factor such that the calibration factor is used in subsequent testing of patient specimens.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: December 19, 2023
    Assignee: Beckman Coulter, Inc.
    Inventor: Carlos A. Ramirez
  • Publication number: 20230005566
    Abstract: Embodiments of the present technology include a method for testing a blood sample for sepsis. The method may include receiving a blood sample from an individual. The method may also include executing an instruction to analyze the blood sample for sepsis. In addition, the method may include measuring values of a set of characteristics in the blood sample. The set of characteristics being determined prior to measuring the values. The method may further include analyzing the values of the set of characteristics to produce a representation of a suspicion of sepsis. In addition, the method may include displaying the representation. Embodiments also include systems for testing blood sample for sepsis.
    Type: Application
    Filed: September 14, 2022
    Publication date: January 5, 2023
    Inventors: Rongchang Xin, Carlos A. Ramirez
  • Patent number: 11538566
    Abstract: It is possible that an analyzer may be operated such that it may perform tests to identify the presence or absence of a specified condition. Such tests may be performed using behaviors which are specific to the specified condition, and the results of those tests may be presented in a single output.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: December 27, 2022
    Assignee: Beckman Coulter, Inc.
    Inventors: Rongchang Xin, Carlos A. Ramirez
  • Patent number: 11521706
    Abstract: Embodiments of the present technology include a method for testing a blood sample for sepsis. The method may include receiving a blood sample from an individual. The method may also include executing an instruction to analyze the blood sample for sepsis. In addition, the method may include measuring values of a set of characteristics in the blood sample. The set of characteristics being determined prior to measuring the values. The method may further include analyzing the values of the set of characteristics to produce a representation of a suspicion of sepsis. In addition, the method may include displaying the representation. Embodiments also include systems for testing blood sample for sepsis.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: December 6, 2022
    Assignee: Beckman Coulter, Inc.
    Inventors: Rongchang Xin, Carlos A. Ramirez
  • Patent number: 11482299
    Abstract: Embodiments of the present technology include a method for testing a blood sample for sepsis. The method may include receiving a blood sample from an individual. The method may also include executing an instruction to analyze the blood sample for sepsis. In addition, the method may include measuring values of a set of characteristics in the blood sample. The set of characteristics being determined prior to measuring the values. The method may further include analyzing the values of the set of characteristics to produce a representation of a suspicion of sepsis. In addition, the method may include displaying the representation. Embodiments also include systems for testing blood sample for sepsis.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: October 25, 2022
    Assignee: Beckman Coulter, Inc.
    Inventors: Rongchang Xin, Carlos A. Ramirez
  • Publication number: 20200049675
    Abstract: Improved systems and methods for laboratory instrument calibration. A laboratory instrument retrieves a number of sets of past quality control parameters from a data structure. Each set includes a recovered value and a timestamp. The recovered value is equal to an output value adjusted by an initial calibration factor. The laboratory instrument determines that the number of sets is greater than a threshold and that each of the past quality control parameters has a timestamp that is within a time threshold. The laboratory instrument computes an updated calibration factor such that when the updated calibration factor is applied to a representative value of the recovered values, the representative value equals the expected recovered value. The instrument updates the data structure with the calibration factor such that the calibration factor is used in subsequent testing of patient specimens.
    Type: Application
    Filed: August 7, 2019
    Publication date: February 13, 2020
    Inventor: Carlos A. Ramirez
  • Publication number: 20190362824
    Abstract: It is possible that an analyzer may be operated such that it may perform tests to identify the presence or absence of a specified condition. Such tests may be performed using behaviors which are specific to the specified condition, and the results of those tests may be presented in a single output.
    Type: Application
    Filed: May 23, 2018
    Publication date: November 28, 2019
    Inventors: Rongchang Xin, Carlos A. Ramirez
  • Publication number: 20190324036
    Abstract: Embodiments of the present technology include a method for testing a blood sample for sepsis. The method may include receiving a blood sample from an individual. The method may also include executing an instruction to analyze the blood sample for sepsis. In addition, the method may include measuring values of a set of characteristics in the blood sample. The set of characteristics being determined prior to measuring the values. The method may further include analyzing the values of the set of characteristics to produce a representation of a suspicion of sepsis. In addition, the method may include displaying the representation. Embodiments also include systems for testing blood sample for sepsis.
    Type: Application
    Filed: April 22, 2019
    Publication date: October 24, 2019
    Inventors: Rongchang Xin, Carlos A. Ramirez
  • Patent number: 9658215
    Abstract: Methods and systems for automatically identifying and enumerating early granulated cells (EGC) in blood samples are disclosed. In one embodiment a method for identifying EGC in a blood sample includes analyzing white blood cells of the blood sample using a low angle light scatter (LALS) parameter, separating the EGCs from the other white blood cells using the LALS parameter, and enumerating the separated EGCs.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: May 23, 2017
    Assignee: Beckman Coulter, Inc.
    Inventors: Carlos A. Ramirez, Jiuliu Lu
  • Patent number: 8644581
    Abstract: In accordance with the principles of the invention, methods, systems, and computer-readable mediums are provided for positioning cellular analysis data including measuring a similarity between pixel data in a target sample data and pixel data in a template data. An offset position is determined based on the measured similarity. The pixel data in the template data is shifted based on the offset position to produce shifted template data having pixel data at shifted locations which match the corresponding pixel data in the target sample data.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: February 4, 2014
    Assignee: Beckman Coulter, Inc.
    Inventors: Carlos A. Ramirez, Jaesang Park, Jiuliu Lu
  • Publication number: 20140030756
    Abstract: Methods and systems for automatically identifying and enumerating early granulated cells (EGC) in blood samples are disclosed. In one embodiment a method for identifying EGC in a blood sample includes analyzing white blood cells of the blood sample using a low angle light scatter (LALS) parameter, separating the EGCs from the other white blood cells using the LALS parameter, and enumerating the separated EGCs.
    Type: Application
    Filed: April 6, 2012
    Publication date: January 30, 2014
    Applicant: BECKMAN COULTER, INC.
    Inventors: Carlos A. Ramirez, Jiuliu Lu
  • Patent number: 8581927
    Abstract: Systems and methods for multidimensional particle analysis data cluster mapping and reconstruction are provided. In one embodiment, a method for reconstructing multidimensional particle analysis data clusters is provided. The method includes obtaining a set of segmented two-dimensional projections corresponding to multidimensional particle analysis data associated with a biological sample of particles. Each segmented two-dimensional projection has two-dimensional clusters associated with particle populations in the biological sample. The method also includes reconstructing one or more multidimensional clusters based on the two-dimensional clusters in the segmented two-dimensional projections.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: November 12, 2013
    Inventors: Carlos A. Ramirez, Jaesang Park, Jiuliu Lu
  • Patent number: 8417012
    Abstract: Systems and methods for non-linear histogram segmentation for particle analysis are provided. In one embodiment, a method for analyzing particles comprises creating an initial two-dimensional histogram based on two selected parameters of the particles, filtering the initial two-dimensional histogram to generate a filtered two-dimensional image, detecting a plurality of seed populations in the filtered two-dimensional image, generating one or more linear contour lines, each having a plurality of contour points, to separate the detected seed populations, and adjusting the contour points in at least one of the linear contour lines to separate the detected seed populations.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: April 9, 2013
    Assignee: Beckman Coulter, Inc.
    Inventors: Carlos A. Ramirez, Jaesang Park, Jiuliu Lu
  • Publication number: 20100110103
    Abstract: Systems and methods for multidimensional particle analysis data cluster mapping and reconstruction are provided. In one embodiment, a method for reconstructing multidimensional particle analysis data clusters is provided. The method includes obtaining a set of segmented two-dimensional projections corresponding to multidimensional particle analysis data associated with a biological sample of particles. Each segmented two-dimensional projection has two-dimensional clusters associated with particle populations in the biological sample. The method also includes reconstructing one or more multidimensional clusters based on the two-dimensional clusters in the segmented two-dimensional projections.
    Type: Application
    Filed: October 29, 2009
    Publication date: May 6, 2010
    Applicant: Beckman Coulter, Inc.
    Inventors: Carlos A. RAMIREZ, Jaesang Park, Jiuliu Lu
  • Publication number: 20100111399
    Abstract: In accordance with the principles of the invention, methods, systems, and computer-readable mediums are provided for positioning cellular analysis data including measuring a similarity between pixel data in a target sample data and pixel data in a template data. An offset position is determined based on the measured similarity. The pixel data in the template data is shifted based on the offset position to produce shifted template data having pixel data at shifted locations which match the corresponding pixel data in the target sample data.
    Type: Application
    Filed: October 29, 2009
    Publication date: May 6, 2010
    Applicant: Beckman Coulter, Inc.
    Inventors: Carlos A. RAMIREZ, Jaesang Park, Jiuliu Lu
  • Publication number: 20100111400
    Abstract: Systems and methods for non-linear histogram segmentation for particle analysis are provided. In one embodiment, a method for analyzing particles comprises creating an initial two-dimensional histogram based on two selected parameters of the particles, filtering the initial two-dimensional histogram to generate a filtered two-dimensional image, detecting a plurality of seed populations in the filtered two-dimensional image, generating one or more linear contour lines, each having a plurality of contour points, to separate the detected seed populations, and adjusting the contour points in at least one of the linear contour lines to separate the detected seed populations.
    Type: Application
    Filed: October 29, 2009
    Publication date: May 6, 2010
    Applicant: Beckman Coulter, Inc.
    Inventors: Carlos A. RAMIREZ, Jaesang PARK, Jiuliu LU
  • Patent number: 7427654
    Abstract: Degradable polyimides are prepared in high yield by polymerizing a monomer containing at least two anhydride groups, and a monomer containing at least two primary amine groups and at least one acidic group, in bulk or in a solvent. The polyimides are very strong in terms of their mechanical properties, yet degradable under standard physiological conditions.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: September 23, 2008
    Assignee: University of Puerto Rico
    Inventors: Guanglou Cheng, Maria Aponte, Carlos A. Ramírez