Patents by Inventor Carlos Castro

Carlos Castro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240085399
    Abstract: In one aspect, a method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos is featured. The method includes acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device, processing the first plurality of images to determine one or more optical absorption gaps located in said capillary, and annotating the first plurality of images with an indication of any optical absorption gap detected in the first plurality of images.
    Type: Application
    Filed: November 14, 2023
    Publication date: March 14, 2024
    Inventors: Carlos Castro Gonzalez, Ian Butterworth, Aurelien Bourquard, Alvaro Sanchez Ferro
  • Publication number: 20240018455
    Abstract: Disclosed herein a robust approach to monitor cell interactions with its surrounding environment in real-time in a physiologically relevant 3-D microenvironment, holding great promise for enhancing future studies of detecting and monitoring cell processes and responses to instructive cues and therapeutic agents. A microfluidic cell culture system is provided that involves a cell sensor in a 3D culture scaffold and one or more microfluidic channels fluidly connected to the 3D culture matrix. The cell sensor involves a planar nucleic acid nanostructure having a top surface and a bottom surface, a plurality sensor molecule attached to the top surface to detect at least two target molecules, and one or more membrane anchoring moieties attached to the bottom surface.
    Type: Application
    Filed: January 13, 2023
    Publication date: January 18, 2024
    Inventors: Melika Shahhosseini, Carlos Castro, Jonathan Song, Ehsan Akbari, Peter Beshay
  • Patent number: 11860154
    Abstract: In one aspect, a method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos is featured. The method includes acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device, processing the first plurality of images to determine one or more optical absorption gaps located in said capillary, and annotating the first plurality of images with an indication of any optical absorption gap detected in the first plurality of images.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: January 2, 2024
    Assignee: Leuko Labs, Inc
    Inventors: Carlos Castro Gonzalez, Ian Butterworth, Aurelien Bourquard, Alvaro Sanchez Ferro
  • Publication number: 20230366042
    Abstract: The present disclosure relates to biosensors and methods of use thereof.
    Type: Application
    Filed: October 1, 2021
    Publication date: November 16, 2023
    Inventors: Patrick HALLEY, Carlos CASTRO, Christopher LUCAS, Melika SHAHHOSSEINI, Alexander MARRAS
  • Patent number: 11813010
    Abstract: Implant tensioning and/or implant anchor deployment devices are described. Certain embodiments may be recognized in the form of a so-called tensioning “gun.” Other embodiments take a simpler and more compact form. Various optional features are described in connection with these embodiments. Optional aspects of anchor embodiments for the subject implants are also described. Some of these features are coordinated for use with the implant tensioning and anchor deployment instrument, others are not.
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: November 14, 2023
    Assignee: MEDEON BIODESIGN, INC.
    Inventors: Kathryn A. Stecco, Carlos Castro, Stephen Powelson, Forrest Grinstead, Damon Covell Campbell
  • Publication number: 20230032932
    Abstract: An automated system for acquiring images of one or more capillaries in a capillary bed includes a platform for receiving a body portion of a subject, an imaging subsystem having a repositionable field of view and coupled to the platform to acquire images of at least a capillary bed of the body portion and a controller communicably coupled to the imaging subsystem to automatically reposition the field of view of the imaging subsystem to different areas of the capillary bed, and at each field of view within the capillary bed, activate the imaging subsystem to acquire images of one or more capillaries in the capillary bed.
    Type: Application
    Filed: August 1, 2022
    Publication date: February 2, 2023
    Inventors: Ian Butterworth, Carlos Castro-Gonzalez, Aurelien Bourquard, Alvaro Sanchez Ferro, Ganimete Lamaj, Nolan Bell, Ryan Benasutti, Alberto Pablo-Trinidad
  • Patent number: 11468122
    Abstract: A method for utilizing shared memory spaces for data lifecycle management in a conversational AI system includes receiving one or more storage requests directing conversational data to multiple nodes of a conversational data object and storing the conversational data that is directed to each different one of the multiple nodes within a different one of multiple discrete memory spaces. Each of the multiple discrete memory spaces is governed by a scope policy defining a lifetime for data stored within the memory space. The method further provides for erasing data of each node of the multiple different nodes of the conversational data object according to the lifetime defined by the scope policy governing the memory space storing the node.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: October 11, 2022
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Steven Wayne Ickman, Thomas Matthew Laird-McConnell, Christopher Clayton McConnell, Carlos Castro, Christopher Lee Mullins, Scott J. Gellock
  • Publication number: 20220254024
    Abstract: A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.
    Type: Application
    Filed: February 7, 2022
    Publication date: August 11, 2022
    Applicants: Massachusetts Institute of Technology, Universidad Politecnica De Madrid
    Inventors: Carlos CASTRO-GONZALEZ, Ian BUTTERWORTH, Aurelien BOURQUARD, Alvaro Sanchez FERRO, Jason TUCKER-SCHWARTZ, Alberto PABLO TRINIDAD, MARIA J. LEDESMA CARBAYO, Tom Vettenburg
  • Patent number: 11244452
    Abstract: A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: February 8, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Carlos Castro-Gonzalez, Ian Butterworth, Aurelien Bourquard, Alvaro Sanchez-Ferro, Jason Tucker-Schwartz, Alberto Pablo-Trinidad, Maria J. Ledesma-Carbayo, Tom Vettenburg
  • Publication number: 20210374963
    Abstract: In one aspect, a method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos is featured. The method includes acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device, processing the first plurality of images to determine one or more optical absorption gaps located in said capillary, and annotating the first plurality of images with an indication of any optical absorption gap detected in the first plurality of images.
    Type: Application
    Filed: May 27, 2021
    Publication date: December 2, 2021
    Inventors: Carlos Castro Gonzalez, Ian Butterworth, Aurelien Bourquard, Alvaro Sanchez Ferro
  • Patent number: 11185328
    Abstract: An endoscopic stapler is disclosed. The stapler includes a staple member and an anvil member. The staple member may include a staple housing and the staple holder may include one or more staples. The anvil member may be spaced apart from the staple member and may configured to relatively move towards one another. A controller may be fluidly coupled to the staple member through a plurality of conduits. The controller may be configured to (a) direct a pressurized fluid to the staple member through a first conduit of the plurality of conduits to relatively move the staple member and the anvil member towards one another, and (b) direct the pressurize fluid through a second conduit of the plurality of conduits to eject one or more staples from the staple holder.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: November 30, 2021
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Carlos Castro, Amador Hallare, Hollie Pope, David Cole
  • Publication number: 20210353332
    Abstract: Bone and joint stabilization devices or systems are described that include multiple-layer bodies. The approach offers dramatically improved fatigue life as compared to one-piece spring members that are otherwise similar or comparable. Coordinated improved-strength anchor embodiments, anchor loading tools and methods of use are also described.
    Type: Application
    Filed: May 26, 2021
    Publication date: November 18, 2021
    Inventors: Kathryn A. Stecco, Frank P. Becking, Carlos Castro, Roger William Sharpe, Damon Covell Campbell
  • Patent number: 11170174
    Abstract: A computer-executed conversational system utilizing adaptive dialogs to provide dynamic modification of a conversation structure. The adaptive dialogs facilitate an adaptive and dynamic way to model conversations. A conversational rule may be associated with a trigger received at an adaptive dialog. The conversational rule may populate a plan with steps to provide the conversational structure of the conversational system. Modifying triggers may be received that allow conversational rules to amend the plan including adding steps, removing steps, or modifying steps from the plan. The adaptive dialogs and/or components thereof may be provided as constructible elements in a platform for building a bot such as a developer Software Development Kit (SDK) or the like. In turn, sophisticated conversational modeling may be conveniently facilitated to provide features such as a dialog dispatcher, the ability to handle interruptions, and to build a pluggable, extensible conversational system.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: November 9, 2021
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Steven Wayne Ickman, Thomas Matthew Laird-McConnell, Christopher Clayton McConnell, Carlos Castro
  • Patent number: 11151333
    Abstract: Conversational event modeling for determining how to process an input in a dialog stack of a computer-executed conversational system. Receipt of an input at an active dialog in a dialog stack may result in generation of an event corresponding to the input. The event may be propagated through the dialog stack. Dialogs in the dialog stack may generate a confidence value in relation to processing the input, and selection of the dialog in the dialog stack for use in processing the input may be based at least in part on the confidence values. In turn, the conversational system may facilitate improved handling of ambiguous or unrelated inputs at dialogs by propagating the event associated with such an input through the dialog stack. The event creation and processing functions may be provided as parameters for dialogs in a modular dialog creation system.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: October 19, 2021
    Assignee: Microsoft Technology Licensing LLC
    Inventors: Steven Wayne Ickman, Thomas Matthew Laird-McConnell, Christopher Clayton McConnell, Carlos Castro
  • Publication number: 20210275237
    Abstract: Components and associated methods of manufacture or assembly and/or use for bone and joint stabilization devices or systems are described. The components include features for device introduction, attaching a distal anchoring foot or threaded screw to an elongate spring-type member, anchoring head features for stabilizing position of the elongate member when engaged within the head and/or digital or electronic methods for tensioning the subject devices.
    Type: Application
    Filed: May 26, 2021
    Publication date: September 9, 2021
    Inventors: Kathryn A. Stecco, Frank P. Becking, Carlos Castro
  • Patent number: 11045225
    Abstract: Bone and joint stabilization devices or systems are described that include multiple-layer bodies. The approach offers dramatically improved fatigue life as compared to one-piece spring members that are otherwise similar or comparable. Coordinated improved-strength anchor embodiments, anchor loading tools and methods of use are also described.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: June 29, 2021
    Assignee: PANTHER ORTHOPEDICS, INC.
    Inventors: Kathryn A. Stecco, Frank P. Becking, Carlos Castro, Roger William Sharpe, Damon Covell Campbell
  • Patent number: 11033308
    Abstract: Components and associated methods of manufacture or assembly and/or use for bone and joint stabilization devices or systems are described. The components include features for device introduction, attaching a distal anchoring foot or threaded screw to an elongate spring-type member, anchoring head features for stabilizing position of the elongate member when engaged within the head and/or digital or electronic methods for tensioning the subject devices.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: June 15, 2021
    Assignee: PANTHER ORTHOPEDICS, INC.
    Inventors: Kathryn A. Stecco, Frank P. Becking, Carlos Castro
  • Publication number: 20210162065
    Abstract: Disclosed herein are DNA origami nanostmcture that can be functionalized for personalized and targeted drug delivery. The disclosed nanostructures enter cells through the endolysosomal pathway and circumvent drug resistance mechanisms in target cells. The disclosed nanostructures can be loaded small molecule drugs (e.g. anthracyclines, anti-metabolites) and nucleic acids (e.g. antisense oligonucleotides, siRNA, miRNA) with targeting and/or therapeutic antibodies against tumor-specific antigens (e.g. anti-CD33, anti-CD20) that can be modified to treat to a wide range of cancers and ultimately tailored to specific patients' needs for precision medicine.
    Type: Application
    Filed: April 9, 2019
    Publication date: June 3, 2021
    Inventors: Carlos Castro, Christopher Lucas, Patrick Halley, John Byrd
  • Publication number: 20210068879
    Abstract: Implant tensioning and/or implant anchor deployment devices are described. Certain embodiments may be recognized in the form of a so-called tensioning “gun.” Other embodiments take a simpler and more compact form. Various optional features are described in connection with these embodiments. Optional aspects of anchor embodiments for the subject implants are also described. Some of these features are coordinated for use with the implant tensioning and anchor deployment instrument, others are not.
    Type: Application
    Filed: September 9, 2020
    Publication date: March 11, 2021
    Inventors: Kathryn A. Stecco, Carlos Castro, Stephen Powelson, Forrest Grinstead, Damon Covell Campbell
  • Publication number: 20200394272
    Abstract: Conversational event modeling for determining how to process an input in a dialog stack of a computer-executed conversational system. Receipt of an input at an active dialog in a dialog stack may result in generation of an event corresponding to the input. The event may be propagated through the dialog stack. Dialogs in the dialog stack may generate a confidence value in relation to processing the input, and selection of the dialog in the dialog stack for use in processing the input may be based at least in part on the confidence values. In turn, the conversational system may facilitate improved handling of ambiguous or unrelated inputs at dialogs by propagating the event associated with such an input through the dialog stack. The event creation and processing functions may be provided as parameters for dialogs in a modular dialog creation system.
    Type: Application
    Filed: June 11, 2019
    Publication date: December 17, 2020
    Inventors: Steven Wayne ICKMAN, Thomas Matthew LAIRD-MCCONNELL, Christopher Clayton MCCONNELL, Carlos CASTRO