Abstract: The invention relates to a nutraceutical formulation of blueberry extract, fish oil (omega-3 and omega-6), recombinant human lactoferrin, vitamin A and vitamin E, for human oral consumption. The invention belongs to the field of ophthalmology and has been developed as a coadjuvant for preserving the health of the precorneal film and of the eye surface. This formulation contains an extract of natural origin (Vaccinium myrtillus L) with antioxidant and anti-inflammatory properties; it also uses eicosapentaenoic acid (EPA), omega-6, and docosahexaenoic acid (DHA), omega-3, obtained from fish oil and which, together with lactoferrin, vitamin A and vitamin E, improves tear quality, since these compounds have anti-microbial and anti-inflammatory effects. This formulation has been designed as a coadjuvant for preserving the health of the precorneal film.

Abstract: A turbocharger includes a housing and a rotating group supported for rotation within the housing. The rotating group includes a compressor wheel disposed within a compressor section of the turbocharger, and the rotating group includes a turbine wheel disposed within a turbine section of the turbocharger. The turbine wheel includes a bleed pressure surface. The turbocharger further includes a bleed passage that extends at least partly through the housing to fluidly connect the compressor section to the turbine section. The bleed passage is configured to direct a bleed flow of fluid from the compressor section to the bleed pressure surface to supply a thrust counterbalance load to the bleed pressure surface.

Abstract: A compressor device includes a coolant jacket cooperatively defined by a motor case and an outer motor housing. The coolant jacket includes a radial portion that spans about the motor case in a circumferential direction and an axial direction with respect to the axis of rotation of the motor. The coolant jacket includes an axial portion that spans in a radial direction across an axial end of the motor case. At least one of the plurality of flow passages fluidly connects the radial portion and the axial portion.

Abstract: Various embodiments of the present disclosure evaluate transcription accuracy. In some implementations, the system normalizes a first transcription of an audio file and a baseline transcription of the audio file. The baseline transcription can be used as an accurate transcription of the audio file. The system can further determine an error rate of the first transcription by aligning each portion of the first transcription with the portion of the baseline transcription, and assigning a label to each portion based on a comparison of the portion of the first transcription with the portion of the baseline transcription.

Abstract: Provided herein are methods of treating B7-H1-expressing tumors comprising administering an effective amount of MEDI4736 or an antigen-binding fragment thereof.

Abstract: An electric machine including a stator and a frame, the stator is supported with support necks on the frame in at least two axially spaced support locations. The support locations include a first group of support necks and a second group of support necks. The support necks in the first group are positioned in connection with a vertical centre plane. The second group includes two side support necks positioned opposite to each other at an angular distance above or below a horizontal centre plane. The angular distance is defined by a first angle which is determined in degrees by the formula ?1=(90/P)±(?)*(90/P), where P is the number of poles of the electric machine and P>2.

Abstract: The present disclosure relates to the use of anti-PAD4 autoantibodies as a clinical biomarker for rheumatoid arthritis (RA) treatment. The disclosure further provides an assay to detect anti-PAD4 autoantibodies, assay kits for the detection of anti-PAD4 autoantibodies, as well as computer implemented diagnostic methods.

Abstract: A rotor assembly for an electric motor for a turbomachine defines an axis of rotation. The rotor assembly includes a jacket member that is hollow and that defines an inner radial surface facing inwardly toward the axis of rotation. Furthermore, the rotor assembly includes a magnet member that is received within the jacket member. The magnet member includes an outer radial surface facing outwardly from the axis of rotation. The jacket member is made of a sintered composite material having carbon filament and a sintered matrix. Additionally, the inner radial surface of the jacket member abuts against the outer radial surface of the magnet member to retain the magnet member in a radial position relative to the axis.

Abstract: The present disclosure relates to the use of anti-PAD4 autoantibodies as a clinical biomarker for rheumatoid arthritis (RA) treatment. The disclosure further provides an assay to detect anti-PAD4 autoantibodies, assay kits for the detection of anti-PAD4 autoantibodies, as well as computer implemented diagnostic methods.

Abstract: A turbocharger includes a housing and a rotating group supported for rotation within the housing. The rotating group includes a compressor wheel disposed within a compressor section of the turbocharger, and the rotating group includes a turbine wheel disposed within a turbine section of the turbocharger. The turbine wheel includes a bleed pressure surface. The turbocharger further includes a bleed passage that extends at least partly through the housing to fluidly connect the compressor section to the turbine section. The bleed passage is configured to direct a bleed flow of fluid from the compressor section to the bleed pressure surface to supply a thrust counterbalance load to the bleed pressure surface.

Abstract: A compressor device includes a motor cooling system that provides a first flow of a first fluid through a housing for cooling a motor. The motor cooling system includes a first fluid flow section at a first axial position. The first fluid flow section extends in a downstream direction radially with respect to the axis of rotation. Also, the device includes a bearing cooling system that provides a second flow of a second fluid through the housing for cooling the bearing. The bearing cooling system includes a second flow section at a second axial position that is spaced apart axially from the first axial position. The second flow section extends in a downstream direction radially with respect to the axis of rotation. The first flow section and the second flow section are disposed in a heat exchanger arrangement configured to transfer heat between the second fluid and the first fluid.

Abstract: A rotor assembly for an electric motor for a turbomachine defines an axis of rotation. The rotor assembly includes a jacket member that is hollow and that defines an inner radial surface facing inwardly toward the axis of rotation. Furthermore, the rotor assembly includes a magnet member that is received within the jacket member. The magnet member includes an outer radial surface facing outwardly from the axis of rotation. The jacket member is made of a sintered composite material having carbon filament and a sintered matrix. Additionally, the inner radial surface of the jacket member abuts against the outer radial surface of the magnet member to retain the magnet member in a radial position relative to the axis.

Abstract: Steerable delivery devices use one or more pull wires. Described herein are devices and methods for securing a pull wire to an adjustment mechanism of such delivery devices. The disclosed devices facilitate securing the pull wire by using a wrapping set screw that forms a lumen for the pull wire and one or more notches in the side of the wrapping set screw at its proximal end. The notches allow the pull wire to be pulled through a notch so that when the wrapping set screw is driven into a threaded lumen the pull wire lies along the roots of the screw. The pull wire is secured in place due at least in part to friction and/or to being pressed between the screw and the threaded lumen of a wrap housing where the wrap housing can be part of the adjustment mechanism of the delivery device.

Abstract: An electric machine including a stator and a frame, the stator is supported with support necks on the frame in at least two axially spaced support locations. The support locations include a first group of support necks and a second group of support necks. The support necks in the first group are positioned in connection with a vertical centre plane. The second group includes two side support necks positioned opposite to each other at an angular distance above or below a horizontal centre plane. The angular distance is defined by a first angle which is determined in degrees by the formula ?1=(90/P)±(?)*(90/P), where P is the number of poles of the electric machine and P>2.

Abstract: A compressor device includes a motor cooling system that provides a first flow of a first fluid through a housing for cooling a motor. The motor cooling system includes a first fluid flow section at a first axial position. The first fluid flow section extends in a downstream direction radially with respect to the axis of rotation. Also, the device includes a bearing cooling system that provides a second flow of a second fluid through the housing for cooling the bearing. The bearing cooling system includes a second flow section at a second axial position that is spaced apart axially from the first axial position. The second flow section extends in a downstream direction radially with respect to the axis of rotation. The first flow section and the second flow section are disposed in a heat exchanger arrangement configured to transfer heat between the second fluid and the first fluid.

Abstract: A compressor device includes a coolant jacket cooperatively defined by a motor case and an outer motor housing. The coolant jacket includes a radial portion that spans about the motor case in a circumferential direction and an axial direction with respect to the axis of rotation of the motor. The coolant jacket includes an axial portion that spans in a radial direction across an axial end of the motor case. At least one of the plurality of flow passages fluidly connects the radial portion and the axial portion.

Abstract: Provided herein are methods of treating B7-H1-expressing tumors comprising administering an effective amount of MEDI4736 or an antigen-binding fragment thereof.

Abstract: A wearable device providing an augmented reality experience for the benefit of hearing impaired persons is disclosed. The augmented reality experience displays a virtual text caption box that includes text that has been translated from speech detected from surrounding speakers.

Abstract: Various embodiments of the present disclosure evaluate transcription accuracy. In some implementations, the system normalizes a first transcription of an audio file and a baseline transcription of the audio file. The baseline transcription can be used as an accurate transcription of the audio file. The system can further determine an error rate of the first transcription by aligning each portion of the first transcription with the portion of the baseline transcription, and assigning a label to each portion based on a comparison of the portion of the first transcription with the portion of the baseline transcription.

Abstract: Provided herein are methods of treating B7-H1-expressing tumors comprising administering an effective amount of MEDI4736 or an antigen-binding fragment thereof.