Abstract: The present disclosure provides for, among other things, methods and systems for detecting, diagnosing, predicting, monitoring, screening for, staging, and/or providing survival prognosis for advanced adenoma and/or colorectal cancer using DNA methylation markers. For example, described herein are DNA methylation markers that enable categorization and prognosis evaluation of advanced adenoma (AA) and/or colorectal cancer (CRC) patients with high accuracy from human biospecimens.

Abstract: A valve assembly includes a first part mountable to a fluid port of a panel and having a first opening for ingress of fluid into the first part from a first side of the panel, and a second opening for egress of fluid out of the first part through the fluid port to a second side of the panel; a second part within the first part for sealing the second opening when in a first position, a deformable member, and a resilient member biased to move the second part to a second position, to provide a fluid flow path from the first opening to the second. In an initial state, the deformable member retains the second part in the first position. Upon contacting liquid within the first part, at least part of the deformable member deforms to enable the resilient member to move the second part to the second position.

Abstract: A valve assembly includes a first part mountable to a fluid port of a panel and having a first opening for ingress of fluid into the first part from a first side of the panel, and a second opening for egress of fluid out of the first part through the fluid port to a second side of the panel; a second part within the first part for sealing the second opening when in a first position, a deformable member, and a resilient member biased to move the second part to a second position, to provide a fluid flow path from the first opening to the second. In an initial state, the deformable member retains the second part in the first position. Upon contacting liquid within the first part, at least part of the deformable member deforms to enable the resilient member to move the second part to the second position.

Abstract: Plug for sealing orifices, particularly for plugging and sealing orifices made in plates of vehicle bodies, basically comprising a body in the form of a pan whose outer wall is peripherally provided on its outer face with an upper flange and a lower flange that are opposite each other and diverge in opposite directions, said flanges defining an intermediate space for receiving the annular segment of the plate that surrounds the orifice to be sealed, and centering ribs to simplify the positioning of the plate and therefore simplify the installation operation, reducing the time needed for this operation.

Abstract: Plug for sealing orifices, particularly for plugging and sealing orifices made in plates of vehicle bodies, basically comprising a body in the form of a pan whose outer wall is peripherally provided on its outer face with an upper flange and a lower flange that are opposite each other and diverge in opposite directions, said flanges defining an intermediate space for receiving the annular segment of the plate that surrounds the orifice to be sealed, and centering ribs to simplify the positioning of the plate and therefore simplify the installation operation, reducing the time needed for this operation.