Patents by Inventor Carlos E. Suarez

Carlos E. Suarez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRANSMISSION-BLOCKING VACCINE AGAINST BABESIA
    Publication number: 20230190905
    Abstract: The present invention relates to a Babesia antigen comprising at least a portion of a gametocyte HAPLESS2/GCS1 (HAP2) protein, vectors and cells expressing such antigen, compositions and kits comprising such antigens, and methods of using such antigens to interfere with the Babesia transmission by competent ticks.
    Type: Application
    Filed: September 26, 2022
    Publication date: June 22, 2023
    Inventors: CARLOS E SUAREZ, JACOB M LAUGHERY, REGINALDO GASPAR BASTOS, MARTA GOMES DA SILVA, HEBA FATHY ALZAN, BRIAN M COOKE, VIGNESH A RATHINASAMY
  • Modified Indirect Enzyme Linked Immunosorbent Assay Optimal for Monitoring Acute and Long Term Carrier Infections of Diverse Babesia bovis Strains
    Publication number: 20190271697
    Abstract: We have developed a modified indirect ELISA (MI-ELISA) using the spherical body protein-4 (SBP4) of Babesia bovis to detect antibody against diverse isolates through all infection stages in cattle. This SBP4 MI-ELISA was evaluated for sensitivity and specificity against field sera and sera from cattle infected experimentally with various doses and isolates as well as in detecting acute and persistent infection. The diagnostic specificity of the SBP4 MI-ELISA using IFA-negative sera was 100%, significantly higher than the RAP-1 cELISA (90.4%); the diagnostic sensitivity of the SBP4 MI-ELISA was 98.7% using the IFA-positive sera, in contrast to that of the RAP-1 cELISA at 60%. Results demonstrate excellent diagnostic sensitivity and specificity of the novel SBP4 MI-ELISA for cattle with acute and long-term carrier infections. Use of the SBP4 MI-ELISA assay in countries that have B. bovis-endemic herds will be pivotal in preventing the spread of this disease to non-endemic herds.
    Type: Application
    Filed: February 2, 2018
    Publication date: September 5, 2019
    Inventors: Carlos E. Suarez, Chungwon J. Chung, Carey L. BANDARANAYAKA MUDIYANSELAGE
  • Modified Indirect Enzyme Linked Immunosorbent Assay Optimal for Monitoring Acute and Long Term Carrier Infections of Diverse Babesia bovis Strains
    Publication number: 20180017556
    Abstract: We have developed a modified indirect ELISA (MI-ELISA) using the spherical body protein-4 (SBP4) of Babesia bovis to detect antibody against diverse isolates through all infection stages in cattle. This SBP4 MI-ELISA was evaluated for sensitivity and specificity against field sera and sera from cattle infected experimentally with various doses and isolates as well as in detecting acute and persistent infection. The diagnostic specificity of the SBP4 MI-ELISA using IFA-negative sera was 100%, significantly higher than the RAP-1 cELISA (90.4%); the diagnostic sensitivity of the SBP4 MI-ELISA was 98.7% using the IFA-positive sera, in contrast to that of the RAP-1 cELISA at 60%. Results demonstrate excellent diagnostic sensitivity and specificity of the novel SBP4 MI-ELISA for cattle with acute and long-term carrier infections. Use of the SBP4 MI-ELISA assay in countries that have B. bovis-endemic herds will be pivotal in preventing the spread of this disease to non-endemic herds.
    Type: Application
    Filed: July 14, 2016
    Publication date: January 18, 2018
    Inventors: Carlos E. Suarez, Chungwon J. Chung, Carey L. Wilson
  • GENETICALLY MODIFIED BABESIA PARASITES EXPRESSING PROTECTIVE TICK ANTIGENS AND USES THEREOF
    Publication number: 20170304416
    Abstract: The present invention relates to methods for stable transfection of Babesia parasites, and for vaccines conferring immunity against parasitic arthropods.
    Type: Application
    Filed: April 26, 2017
    Publication date: October 26, 2017
    Inventors: Carlos E. Suarez, Donald P. Knowles, Jr., Terry McElwain
  • Genetically modified babesia parasites expressing protective tick antigens and uses thereof
    Patent number: 9707283
    Abstract: The present invention relates to methods for stable transfection of Babesia parasites, and for vaccines conferring immunity against parasitic arthropods.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: July 18, 2017
    Assignees: The United States of America, as represented by the Secretary of Agriculture, Washington State University
    Inventors: Carlos E. Suarez, Donald P. Knowles, Jr., Terry McElwain
  • GENETICALLY MODIFIED BABESIA PARASITES EXPRESSING PROTECTIVE TICK ANTIGENS AND USES THEREOF
    Publication number: 20160158327
    Abstract: The present invention relates to methods for stable transfection of Babesia parasites, and for vaccines conferring immunity against parasitic arthropods.
    Type: Application
    Filed: January 14, 2016
    Publication date: June 9, 2016
    Inventors: Carlos E. Suarez, Donald P. Knowles, JR., Terry McElwain
  • Genetically modified parasites expressing protective tick antigens and uses thereof
    Patent number: 9265818
    Abstract: The present invention relates to methods for stable transfection of Babesia parasites, and for vaccines conferring immunity against parasitic arthropods.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: February 23, 2016
    Assignees: The United States of America, as represented by the Secretary of Agriculture, Washington State University Research Foundation
    Inventors: Carlos E. Suarez, Donald P. Knowles, Jr., Terry F. McElwain
  • Genetically Modified Babesia Parasites Expressing Protective Tick Antigens and Uses Thereof
    Publication number: 20080317786
    Abstract: The present invention relates to methods for stable transfection of Babesia parasites, and for vaccines conferring immunity against parasitic arthropods.
    Type: Application
    Filed: May 5, 2008
    Publication date: December 25, 2008
    Applicants: The United States of America, As represented by the Secretary of Agriculture, Washington State University Research Foundation
    Inventors: Carlos E. Suarez, Donald P. Knowles, JR., Terry F. McElwain