Abstract: Embodiments of the invention are related to methods and devices for respiratory or cardiac disease detection, monitoring, and/or management. In an embodiment, the invention includes a method of calculating a pulmonary function parameter of a subject. The method can include obtaining a first signal indicative of lung volume change during breathing from a first sensor, obtaining a second signal indicative of distending pressure from a second sensor, and calculating the pulmonary function parameter based on the first signal and the second signal. In an embodiment, the invention includes a method of monitoring pulmonary or cardiac disease status. In an embodiment, the invention includes an implantable medical device.