Patents by Inventor Carlos Fleet

Carlos Fleet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REVERSIBLE COATING OF CHITOSAN-NUCLEIC ACID NANOPARTICLES AND METHODS OF THEIR USE
    Publication number: 20220395584
    Abstract: Chitosan-nucleic acid polyplex compositions containing a reversibly bound polymer coat comprising linear block copolymers with a polyanionic anchor region and at least one polyethylene glycol tail region are described herein. In some cases, the compositions exhibit improved stability and/or mucosal diffusion as compared to uncoated particles. In some cases, the reversibly bound polymer coat does not interfere with, or enhances, transfection of target cells or tissues as compared to uncoated particles.
    Type: Application
    Filed: March 13, 2020
    Publication date: December 15, 2022
    Inventors: Rajesh Krishnan Gopalakrishna PANICKER, Daniel VEILLEUX, Pei Lian MA, Natalie Chin Mun TAM, Carlos FLEET, Anthony CHEUNG
  • CHITOSAN POLYPLEX-BASED LOCALIZED EXPRESSION OF IL-12 ALONE OR IN COMBINATION WITH TYPE-I IFN INDUCERS FOR TREATMENT OF MUCOSAL CANCERS
    Publication number: 20220370637
    Abstract: The present disclosure relates to methods and compositions comprising derivatized-chitosan polyplexes reversibly coated with a polyanion-containing block co-polymer for the localized expression of IL-12 in mucosal tissues, preferably in combination with an IFN-1 activator/inducer, for use in cancer immunotherapy.
    Type: Application
    Filed: March 13, 2020
    Publication date: November 24, 2022
    Inventors: Rajesh Krishnan Gopalakrishna PANICKER, Daniel VEILLEUX, Pei Lian MA, Natalie Chin Mun TAM, Carlos FLEET, Anthony CHEUNG, Shauna DAUPHINEE, Ximin CHEN, Jose LORA
  • High concentration chitosan-nucleic acid polyplex compositions
    Patent number: 10647785
    Abstract: The invention provides highly concentrated chitosan-nucleic acid polyplex compositions and dispersions, and methods for producing the compositions and dispersions. Methods of mixing the chitosan-nucleic acid polyplexes include an inline mixing of chitosan solution and nucleic acid solution, followed by further concentrating the dispersion of chitosan-nucleic acid polyplexes, optionally with an aggregation inhibitor. Further provides are methods for altering the diameter of chitosan-nucleic acid polyplexes.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: May 12, 2020
    Assignee: ENGENE, INC.
    Inventors: Eric Hsu, Carlos Fleet, Anthony Cheung, Jun Gao
  • HIGH CONCENTRATION CHITOSAN-NUCLEIC ACID POLYPLEX COMPOSITIONS
    Publication number: 20180215839
    Abstract: The invention provides highly concentrated chitosan-nucleic acid polyplex compositions and dispersions, and methods for producing the compositions and dispersions. Methods of mixing the chitosan-nucleic acid polyplexes include an inline mixing of chitosan solution and nucleic acid solution, followed by further concentrating the dispersion of chitosan-nucleic acid polyplexes, optionally with an aggregation inhibitor. Further provides are methods for altering the diameter of chitosan-nucleic acid polyplexes.
    Type: Application
    Filed: December 20, 2017
    Publication date: August 2, 2018
    Inventors: Eric HSU, Carlos Fleet, Anthony CHEUNG, Jun GAO
  • High concentration chitosan-nucleic acid polyplex compositions
    Patent number: 9850323
    Abstract: The invention provides highly concentrated chitosan-nucleic acid polyplex compositions and dispersions, and methods for producing the compositions and dispersions. Methods of mixing the chitosan-nucleic acid polyplexes include an inline mixing of chitosan solution and nucleic acid solution, followed by further concentrating the dispersion of chitosan-nucleic acid polyplexes, optionally with an aggregation inhibitor. Further provides are methods for altering the diameter of chitosan-nucleic acid polyplexes.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: December 26, 2017
    Assignee: ENGENE, INC.
    Inventors: Eric Hsu, Carlos Fleet, Anthony Cheung, Jun Gao
  • High Concentration Chitosan-Nucleic Acid Polyplex Compositions
    Publication number: 20140350091
    Abstract: The invention provides highly concentrated chitosan-nucleic acid polyplex compositions and dispersions, and methods for producing the compositions and dispersions. Methods of mixing the chitosan-nucleic acid polyplexes include an inline mixing of chitosan solution and nucleic acid solution, followed by further concentrating the dispersion of chitosan-nucleic acid polyplexes, optionally with an aggregation inhibitor. Further provides are methods for altering the diameter of chitosan-nucleic acid polyplexes.
    Type: Application
    Filed: April 30, 2014
    Publication date: November 27, 2014
    Applicant: enGene, Inc.
    Inventors: Eric HSU, Carlos FLEET, Anthony CHEUNG, Jun GAO
  • High concentration chitosan-nucleic acid polyplex compositions
    Patent number: 8722646
    Abstract: The invention provides highly concentrated chitosan-nucleic acid polyplex compositions and dispersions, and methods for producing the compositions and dispersions. Methods of mixing the chitosan-nucleic acid polyplexes include an inline mixing of chitosan solution and nucleic acid solution, followed by further concentrating the dispersion of chitosan-nucleic acid polyplexes, optionally with an aggregation inhibitor. Further provided are methods for altering the diameter of chitosan-nucleic acid polyplexes.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: May 13, 2014
    Assignee: enGene, Inc.
    Inventors: Eric Hsu, Carlos Fleet, Anthony Cheung, Jun Gao
  • High Concentration Chitosan-Nucleic Acid Polyplex Compositions
    Publication number: 20110039917
    Abstract: The invention provides highly concentrated chitosan-nucleic acid polyplex compositions and dispersions, and methods for producing the compositions and dispersions. Methods of mixing the chitosan-nucleic acid polyplexes include an inline mixing of chitosan solution and nucleic acid solution, followed by further concentrating the dispersion of chitosan-nucleic acid polyplexes, optionally with an aggregation inhibitor. Further provided are methods for altering the diameter of chitosan-nucleic acid polyplexes.
    Type: Application
    Filed: September 26, 2008
    Publication date: February 17, 2011
    Inventors: Eric C Hsu, Carlos Fleet, Anthony Cheung, Jun Gao
  • Highly Acidic Chitosan-Nucleic Acid Polyplex Compositions
    Publication number: 20100261780
    Abstract: The invention provides highly acidic chitosan-nucleic acid polyplex compositions. The compositions may be used to transfect cells in vitro and in vivo, and are particularly useful for transfecting cells of mucosal epithelia.
    Type: Application
    Filed: March 31, 2010
    Publication date: October 14, 2010
    Applicant: enGene, Inc.
    Inventors: Jun GAO, Carlos Fleet, Eric Hsu, Anthony Cheung