Abstract: Nucleotides encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein are provided herein. Also describe are mRNA constructs that can be used to express CFTR protein in vitro or in vivo. The mRNA constructs can be formulated in a lipid formulation and administered via inhalation to treat cystic fibrosis.

Abstract: Nucleotides encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein are provided herein. Also describe are mRNA constructs that can be used to express CFTR protein in vitro or in vivo. The mRNA constructs can be formulated in a lipid formulation and administered via inhalation to treat cystic fibrosis.

Abstract: Methods and systems for controlling a view of a virtual camera in a virtual world. A view of user viewing a virtual world may be controlled or changed while accounting for a user's head position. For example, a virtual camera may be wrapped in a container such that rotation of the container causes rotation of the virtual camera relative to a global coordinate system. Based on a position of a head-mounted display, an initial virtual camera rotation angle relative to a global coordinate system of the virtual world may be identified. An indication to change to view to particular direction may be received. A desired rotation angle relative to the global coordinate system for a view to correspond to the particular direction is then determined. The container is then rotated by a rotation value based at least on both the desired rotation angle and the initial virtual camera rotation angle.

Abstract: The present disclosure provides a modified human OTC protein having improved properties for the treatment of OTC deficiency in a patient. Preferably, the protein of the disclosure is produced from a codon optimized mRNA suitable for administration to a patient suffering from OTC deficiency wherein upon administration of the mRNA to the patient, the protein of the disclosure is expressed in the patient in therapeutically effective amounts to treat OTC deficiency. The present disclosure also provides codon optimized mRNA sequences encoding wild type human OTC comprising a 5? UTR derived from a gene expressed by Arabidopsis thaliana for use in treating OTC deficiency in a patient.

Abstract: The present disclosure provides a modified human OTC protein having improved properties for the treatment of OTC deficiency in a patient. Preferably, the protein of the disclosure is produced from a codon optimized mRNA suitable for administration to a patient suffering from OTC deficiency wherein upon administration of the mRNA to the patient, the protein of the disclosure is expressed in the patient in therapeutically effective amounts to treat OTC deficiency. The present disclosure also provides codon optimized mRNA sequences encoding wild type human OTC comprising a 5? UTR derived from a gene expressed by Arabidopsis thaliana for use in treating OTC deficiency in a patient.

Abstract: Lipid formulations that encapsulate messenger RNA (mRNA) are provided herein. The mRNA can be used to express CFTR protein in vitro or in vivo. The lipid formulations can be administered via inhalation to treat cystic fibrosis.

Abstract: Methods and systems for controlling a view of a virtual camera in a virtual world. A view of user viewing a virtual world may be controlled or changed while accounting for a user's head position. For example, a virtual camera may be wrapped in a container such that rotation of the container causes rotation of the virtual camera relative to a global coordinate system. Based on a position of a head-mounted display, an initial virtual camera rotation angle relative to a global coordinate system of the virtual world may be identified. An indication to change to view to particular direction may be received. A desired rotation angle relative to the global coordinate system for a view to correspond to the particular direction is then determined. The container is then rotated by a rotation value based at least on both the desired rotation angle and the initial virtual camera rotation angle.

Abstract: Methods and systems for controlling a view of a virtual camera in a virtual world. A view of user viewing a virtual world may be controlled or changed while accounting for a user's head position. For example, a virtual camera may be wrapped in a container such that rotation of the container causes rotation of the virtual camera relative to a global coordinate system. Based on a position of a head-mounted display, an initial virtual camera rotation angle relative to a global coordinate system of the virtual world may be identified. An indication to change to view to particular direction may be received. A desired rotation angle relative to the global coordinate system for a view to correspond to the particular direction is then determined. The container is then rotated by a rotation value based at least on both the desired rotation angle and the initial virtual camera rotation angle.

Abstract: The present disclosure provides a modified human protein having improved in vivo stability. The modified human protein has been altered from a wild-type human protein at either at least one ubiquitination site, at the signal peptide portion, or both. The protein of the disclosure can be produced from a codon optimized mRNA suitable for administration to a patient suffering from deficiency of the wild-type protein, wherein upon administration of the mRNA to the patient, the modified protein of the disclosure is expressed in the patient in therapeutically effective amounts.

Abstract: Nucleotides encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein are provided herein. Also describe are mRNA constructs that can be used to express CFTR protein in vitro or in vivo. The mRNA constructs can be formulated in a lipid formulation and administered via inhalation to treat cystic fibrosis.

Abstract: This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or polypeptide can contain one or more 5? UTRs, where a 5? UTR may be expressed by a gene of a plant. In some embodiments, a 5? UTR may be expressed by a gene of a member of Arabidopsis genus. The synthetic mRNA constructs can be used as pharmaceutical agents for expressing a target protein or polypeptide in vivo.

Abstract: A method, system, and computer program, for providing the virtual object in the virtual or semi-virtual environment, based on a characteristic associated with the user. In one example embodiment, the system comprises at least one computer processor, and a memory storing instructions that, when executed by the at least one computer processor, perform a set of operations comprising determining the characteristic associated with the user in the virtual or semi-virtual environment with respect to a predetermined reference location in the environment, and providing a virtual object based on the characteristic.

Abstract: This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or polypeptide can contain one or more 5? UTRs, where a 5? UTR may be expressed by a gene of a plant. In some embodiments, a 5? UTR may be expressed by a gene of a member of Arabidopsis genus. The synthetic mRNA constructs can be used as pharmaceutical agents for expressing a target protein or polypeptide in vivo.

Abstract: Systems and methods for determining a document library to sync to a local computing device. In one example, the method includes determining, with an electronic processor, one or more document libraries associated with a user; determining, with the electronic processor, a heuristic for each of the one or more document libraries; and determining, with the electronic processor, a subset of the one or more document libraries to sync to a local computing device associated with the user, wherein the subset is determined based upon the heuristic.

Abstract: Systems and methods for opening a file via a user device. One system includes an electronic processor. The electronic processor is configured to receive a request to open the file, determine a file type of the file, determine an application installed on the user device configured to open files of the file type, and determine a version of the application installed on the user device. The electronic processor is also configured to compare the version of the application installed on the user device to a predetermined version, and selectively open the file using a web-based adaptation of the application based on comparing the version of the application installed on the user device to the predetermined version.

Abstract: A desired state system monitors an activity of a first product operating on a machine. The desired state system determines a second product that is connected to the first product. The first product and the second product are both part of a family of products. The desired state system determines an activity of the second product installed on the machine, and a desired activity of the second product on the machine. The activity of the second product is compared with the desired activity of the second product. The desired state system generates a customized message based on the comparison at the machine.

Abstract: The present disclosure provides a modified human OTC protein having improved properties for the treatment of OTC deficiency in a patient. Preferably, the protein of the disclosure is produced from a codon optimized mRNA suitable for administration to a patient suffering from OTC deficiency wherein upon administration of the mRNA to the patient, the protein of the disclosure is expressed in the patient in therapeutically effective amounts to treat OTC deficiency. The present disclosure also provides codon optimized mRNA sequences encoding wild type human OTC comprising a 5? UTR derived from a gene expressed by Arabidopsis thaliana for use in treating OTC deficiency in a patient.

Abstract: Providing user interaction guidance for services and associated applications may become more difficult as their variety and depth increases. Embodiments are directed to managing activation of and providing guidance on how to use a hosted service. For example, an initial configuration of a user interface (UI) of the hosted service that includes at least one element to highlight functionality may be provided for display. An initial action may be received from a user associated with the functionality, the initial action may be performed, and the UI may be updated to reflect the performed initial action. The initial action may be an activation action or upload action, for example. Additionally, a teaching UI element with a celebratory message to highlight the performed initial action and to provide additional information may be provided for display and rendered at a proximate position to a representation of the performed initial action.

Abstract: A desired state system monitors an activity of a first product operating on a machine. The desired state system determines a second product that is connected to the first product. The first product and the second product are both part of a family of products. The desired state system determines an activity of the second product installed on the machine, and a desired activity of the second product on the machine. The activity of the second product is compared with the desired activity of the second product. The desired state system generates a customized message based on the comparison at the machine.

Abstract: A method, system, and computer program, for providing the virtual object in the virtual or semi-virtual environment, based on a characteristic associated with the user. In one example embodiment, the system comprises at least one computer processor, and a memory storing instructions that, when executed by the at least one computer processor, perform a set of operations comprising determining the characteristic associated with the user in the virtual or semi-virtual environment with respect to a predetermined reference location in the environment, and providing a virtual object based on the characteristic.