Abstract: A catheter assembly includes an elongate catheter body defining a longitudinal axis, and a plurality of cooling needles configured to be extended from the catheter body to penetrate a vessel wall of a vessel in which the elongate catheter body is positioned and extend to an ablation region within tissue adjacent the vessel wall. At least one cooling needle of the plurality of cooling needles is further configured to receive a flow of cryogenic fluid to cool the at least one cooling needle.

Abstract: A system may include a catheter that includes an elongated member configured to navigate through a vasculature of a patient to a target treatment site and a plurality of expandable members arranged at a distal portion of the member. Each expandable member may include a corresponding two or more therapeutic elements arranged along a length of the expandable member. Each expandable member of the plurality of expandable members may be configured to assume a delivery configuration and a radially expanded configuration. Each expandable member may be configured to position the corresponding two or more therapeutic elements near a vessel wall so that the therapeutic elements are spaced around a perimeter of the vessel wall. In some examples, distal portions of the plurality of expandable members may be connected to each other at a distal tip of the catheter.

Abstract: A medical device including an elongated shaft having a proximal end, a distal end, and a lumen therethrough. An expandable element is disposed proximate the distal end about the elongated shaft and in fluid communication with the lumen. An inner shaft is disposed within the lumen and within a portion of the expandable element, the inner shaft defining an exhaust port, an infusion port, and a pressure monitoring port. The pressure monitoring port is spaced from both the infusion port and the exhaust port and/or fluidly isolated from the both the infusion port and the exhaust port within the inner shaft. A pressure monitoring tube is disposed within the inner shaft and configured to measure a fluid pressure within the expandable element, with a distal end of the pressure monitoring tube terminating within the expandable element adjacent the pressure monitoring port.

Abstract: A medical device including a proximal end portion and a distal end portion opposite the proximal end portion. An elongate shaft is disposed between the proximal and distal end portions and defines a lumen therebetween. The distal end portion includes a plurality of tubes extending from a distal end of the elongate shaft, the plurality of tubes defining a fluid pathway therein in communication with the lumen for circulation of cryogenic fluid, the plurality of tubes having a common exhaust lumen in fluid communication with the lumen.

Abstract: An example computing device includes a memory; and processing circuitry coupled to the memory, the processing circuitry being configured to: receive renal arterial anatomy information of a patient; determine one or more of a location of renal denervation therapy or a modality of renal denervation therapy to apply to the patient based on the renal arterial anatomy information; and output an indication of one or more of the determined location to apply renal denervation therapy to the patient or the determined modality of renal denervation therapy to apply to the patient.

Abstract: A medical device includes an elongate shaft having an inner shaft is disposed within the elongate shaft, the inner shaft defines a first lumen defining a dedicated first port; an exhaust lumen offset from the first lumen and defining a dedicated second port; a second lumen offset from the first lumen and the exhaust lumen, the second lumen defining a dedicated third port; a third lumen offset from the first lumen, the exhaust lumen, and the second lumen, the third lumen defining a dedicated fourth port; an expandable member enclosing the dedicated first, second, third, and fourth ports. The dedicated first, second, third, and fourth ports are defined at different radial positions about the inner shaft.

Abstract: A medical device includes an elongate shaft having a proximal end portion, a distal end portion, and a defining a lumen therebetween. The distal end portion defines al least one slot. An expandable member is disposed, within the lumen, the expandable member being configured to protrude outward from the at least one slot when expanded with cryogenic fluid.

Abstract: A cryoablation catheter includes an inner lumen and an inflatable balloon surrounding the inner lumen. An inflow pipe is disposed within the inflatable balloon and is configured to introduce a refrigerant into the balloon. A thermocouple wire is disposed within the inflatable balloon and positioned adjacent the inflow pipe. The thermocouple wire is configured to measure an internal temperature of the balloon. The cryoablation catheter further includes an isolation guide disposed within the inflatable balloon. The isolation guide includes a central bore configured to receive the inner lumen, an inflow bore configured to receive the inflow pope, and a thermocouple bore configured to receive the thermocouple wire. The thermocouple bore is spaced from the inflow bore along the isolation guide.

Abstract: A system includes an intravascular medical device and a therapeutic medical device. The intravascular medical device includes a heat therapy assembly and an elongated member coupled to the heat therapy assembly. The heat therapy assembly is configured to expand a vessel beyond an initial size of the vessel and deliver energy to a wall of the expanded vessel to heat the wall of the vessel. The therapeutic medical device is communicatively coupled to the heat therapy assembly and configured to control the heat therapy assembly to deliver the energy to ablate smooth muscle cells of the wall of the vessel and substantially denature one or more structural proteins of the wall of the vessel.

Abstract: A system includes an intravascular medical device and a therapeutic medical device. The intravascular medical device includes a heat therapy assembly and an elongated member coupled to the heat therapy assembly. The heat therapy assembly is configured to contract a wall of a vessel and deliver energy to the wall of the contracted vessel to heat the wall of the vessel. The therapeutic medical device is communicatively coupled to the heat therapy assembly and configured to control the heat therapy assembly to deliver the energy to ablate smooth muscle cells of the wall of the vessel and substantially denature one or more structural proteins of the wall of the vessel.

Abstract: In examples, a cold therapy system includes an intravascular medical device and a therapeutic medical device. The intravascular medical device includes a cold therapy assembly and an elongated member. The cold therapy assembly includes one or more surfaces configured to remove heat from the wall of the vessel. The elongated member is coupled to the cold therapy assembly. The therapeutic medical device is communicatively coupled to the cold therapy assembly and is configured to control the cold therapy assembly to ablate smooth muscle cells of the wall of the vessel without substantially denaturating one or more structural proteins of the wall of the vessel.