Abstract: Provided herein are methods, uses, and compositions for treating AF in a patient, such as a patient exhibiting heart failure with reduced ejection fraction.

Abstract: Disclosed herein are methods of treatment comprising administering a therapeutically effective amount of a myosin modulator or a pharmaceutically acceptable salt thereof to a subject in need thereof and diagnostic methods useful in connection with those treatments. Due to observations unfolding in clinical trials with mavacamten and with mavacamten and other myosin inhibitors in the pre-clinical setting, new insights into how myosin inhibitors can be used beneficially to impact the disease state of HCM and other diseases are provided herein.

Abstract: A method for detecting a quantitative measure of a physiologic state of a human myocardium or coronary artery. Implementations of the method detect the extent of change of myocardial electrical impedance from a mean baseline value to provide diagnosis of the extent of ischemia, stenosis, tissue rejection, and reperfusion and the effectiveness of cardioplegia and ischemia pre-conditioning as well as the general effectiveness of coronary bypass surgery as measured by post-operative reperfusion. Electrodes are attached to the myocardium, baseline measurements of the mean myocardial electrical impedance are stored and the variance of the myocardial electrical impedance and a baseline value of mean myocardial electrical impedance are computed from the baseline measurements and stored. Mean myocardial electrical impedance values are periodically measured between each electrode pair over an interval of time and stored.