Abstract: The invention relates to a composition comprising melatonin, a metabolite or derivative thereof and coenzyme Q10 and to use thereof for the production of a pharmaceutical or cosmetic composition for the treatment of the skin, said composition potentiating the movement of both molecules into the mitochondrion and facilitating percutaneous absorption, in which both the melatonin and the CoQ10 can reach all of the strata of the skin.

Abstract: A torque transmission assembly including a hydrodynamic torque convener able to be coupled to a crankshaft on the one hand, and able to be coupled to a gearbox input shaft on the other, the torque converter including a primary element and a secondary element which are rotationally mobile about an axis of rotation, and damping means including a transmission member and a bearing element, the transmission member including an elastic leaf rotating as one with the primary element or with the secondary element, and the bearing element being home by the secondary element or by the primary element respectively, the elastic leaf being capable of flexing and of transmitting a rotational torque between the primary element and the secondary clement, the flexing of the elastic leaf being accompanied by a relative rotation between the primary and secondary elements.

Abstract: Disclosed is a method of preparing an oxa-bicycloalkene via the reaction of a cycloalkanone and an allyl alcohol compound in the presence of an organic acid, a manganese catalyst, and oxygen at a predetermined temperature.

Abstract: This disclosure relates to salt forms of ceftolozane, processes for making these salt forms, and compositions comprising the same. Also disclosed are stabilized compositions of ceftolozane. Provided herein are salt forms of ceftolozane, processes for making these salt forms and compositions comprising the same. The salt forms provided herein include ceftolozane bromide, ceftolozane edisylate, ceftolozane mesylate, ceftolozane chloride, ceftolozane sulfate, ceftolozane maleate, ceftolozane phosphate, and ceftolozane ketoglutarate.

Abstract: The present invention claims an isolated nucleotide sequence characterized by encoding the PFR1 protein of Leishmania infantum or a fragment thereof. This PFR1 protein or a fragment thereof comprises at least a selected immunodominant epitope between the following group: SEQ ID No: 1, SEQ ID No: 2, SEQ ID No: 3, SEQ ID No: 4, SEQ ID No: 5, SEQ ID No: 6, SEQ ID No: 7 and SEQ ID No: 8, where the immunodominant epitope is able to induce an antigen-specific T cell cytotoxic immune response in an animal, against the kinetoplastids causing the leishmaniasis disease. The immunodominant epitopes are cytotoxic T-lymphocyte activators and they present a high binding affinity for A2 type MHC Class I molecule.

Abstract: Embodiments of the present disclosure are related to electronic commerce within instant messaging. A system may include a commerce server and an instant messaging server. The instant messaging server is configured to support an instant messaging service with an instant messaging client. The instant messaging server may include an application for supporting further communication in the instant messaging service between the instant messaging client and the commerce server. The method includes first instant messaging a query to an instant messaging client and receiving a response to the query at an application at an instant messaging server. The method further includes second instant messaging query results to the instant messaging client with the query results determined at a commerce server and based on the response.

Abstract: A system for providing energy to a bio-implantable medical device includes an acoustic energy delivery device and a bio-implantable electroacoustical energy converter. The acoustic energy delivery device generates acoustic energy with a multi-dimensional array of transmitting electroacoustical transducers. The acoustic energy is received by one or more receiving electroacoustical transducers in the bio-implantable electroacoustical energy converter. The receiving electroacoustical transducers convert the acoustic energy to electrical energy to power the bio-implantable medical device directly or indirectly. An external alignment system provides lateral and/or angular positioning of an ultrasound energy transmitter over an ultrasound energy receiver. The acoustic energy transmitter alignment system comprises either or both x-y-z plus angular positioning components, and/or a substantially multi-dimensional array of transmitters plus position sensors in both the transmitter and receiver units.

Abstract: The present invention relates a perforation system to be installed on a binding machine, the perforation system including a first elongated platform; a second elongated platform aligned with the first elongated platform; vertical bars to vertically connect the first elongated platform with the second elongated platform; a third elongated platform having a first end fixed to the second elongated platform and a second end secured to a surface on the binding machine; the first elongated platform includes holes and a punch passing through each hole, the holes and the punches have a shape with a length greater than a width; the second elongated platform includes guiding holes aligned with the holes and punches of the first platform, the guiding holes have a shape with a length greater than a width; the third elongated platform includes a row of perforations having a shape with a length greater a width; the holes, punches, guiding holes, and perforation have the same shape; the first elongated platform has a length

Abstract: This invention focuses on electrooptic devices and in particular on electrochromic (EC) devices with several aspects directed towards automotive EC mirrors and windows. Adhesive compositions are disclosed herein which improve device processing attributes and their performance and durability.

Abstract: This disclosure relates to salt forms of ceftolozane, processes for making these salt forms, and compositions comprising the same. Also disclosed are stabilized compositions of ceftolozane. Provided herein are salt forms of ceftolozane, processes for making these salt forms and compositions comprising the same. The salt forms provided herein include ceftolozane bromide, ceftolozane edisylate, ceftolozane mesylate, ceftolozane chloride, ceftolozane sulfate, ceftolozane maleate, ceftolozane phosphate, and ceftolozane ketoglutarate.

Abstract: The invention relates to a damper, in particular for an automobile clutch, comprising: an input element and an output element rotationally movable with respect to one another around a rotation axis (X); and one of the input and output elements is equipped with a cam follower (21); damping means interposed between the input and output elements; the damping means have a flexible blade (17a; 17b), and the flexible blade is provided with a cam surface (20) arranged to interact with the cam follower, that cam surface extending over an opening angle (A) greater than 30°, in particular 45°.

Abstract: A global data service connection manager determines a shared data account balance for data available to a user as a function of data amounts previously made available to a shared data system by the first user for the use of other registered users. In response to a request by the first user to execute a data transaction by using data from the shared system, the shared data account balance and the data available at the brokered purchase price are automatically arbitrated to acquire at least one of data from a wireless service account of another registered user of the shared system in an amount that does not exceed the first user's shared data account balance, and data purchased from a wireless service account of another registered user of the shared system in a purchased amount that does not exceed data available at a brokered purchase price.

Abstract: Relates to an improved universal industrial product to be installed on an existing binding or spiral binding machine, capable of binding in all existing binding systems that allow to perform a single set of oblong perforations, according to the paper size, and in which the support or receive the rings, spirals, or combs and binder having multiple size rings, which are currently formed by using machines with different perforation steps. Includes perforation dies having an oblong shape.

Abstract: A global data service connection manager determines a shared data account balance for data available to a user as a function of data amounts previously made available to a shared data system by the first user for the use of other registered users. In response to a request by the first user to execute a data transaction by using data from the shared system, the shared data account balance and the data available at the brokered purchase price are automatically arbitrated to acquire at least one of data from a wireless service account of another registered user of the shared system in an amount that does not exceed the first user's shared data account balance, and data purchased from a wireless service account of another registered user of the shared system in a purchased amount that does not exceed data available at a brokered purchase price.

Abstract: An antenna for motor vehicles is provided having a base member, an antenna device, a radome, and a device for attaching the base member to a vehicle roof inside surface with the antenna device projecting outwards of the vehicle from within through an opening formed in the vehicle. The radome cooperates with the attaching device and the surroundings of the vehicle opening so as to enclose the antenna device in an assembled condition.

Abstract: The present invention provides a method for re-growing hair in patients with androgenic alopecia by administering effective consecutive courses of Granulocyte-Colony Stimulating Factor or derivatives. After the state of re-growth is obtained, the hair growth is maintained by administering periodic courses of Granulocyte-Colony Stimulating Factor or derivatives. The invention further provides a method for increasing cuticle growth and density using a similar administration of effective consecutive courses of Granulocyte-Colony Stimulating Factor or derivatives. The increased cuticle growth and density is maintained by administering periodic courses of Granulocyte-Colony Stimulating Factor or derivatives.

Abstract: A manual paint system comprises a holster with cooperatively formed paint reservoir that fixates to the painter's person. The holster is in fluid communication via a valve with a reservoir that holds fresh clean paint. The holster receives a regulated flow of paint when the valve is open. The holster includes a fixator for securing the applicator so that the handle is available for easy grasp while the brush bristles or roller remain wet in paint within the holster. Scrapers within the holster remove excess paint from the applicator and are configured to return the excess paint to the holster for later use. The fixator may be attached to a gate that slideably opens and closes the valve, thereby allowing the painter to load the holster with paint by simply pulling out the applicator and shut off the flow by pushing the applicator back into the holster.

Abstract: The application discloses and claims a beverage container lid that tracks the amount of fluid consumed. The lid has a standard drinking nozzle and engagement means which includes a gasket or standard threading that sealably fit commercially available beverage containers and water bottles. The exterior of the lid has a reset button and a display window through which a display readout is visible that displays the amount of fluid consumed. The lid houses the display, a CPU, battery, sensors and internal housing through which the water flows. The internal housing has a water wheel inside of it with curved blades that are turned by the beverage as it flows out of the lid. Magnets are affixed to one or more of the blades. The CPU tracks the number of times the magnets pass the sensors and translates it into the amount of fluid consumed, which is shown on the display.

Abstract: The present invention provides a method for re-growing hair in patients with androgenic alopecia by administering effective consecutive courses of Granulocyte-Colony Stimulating Factor or derivatives. After the state of re-growth is obtained, the hair growth is maintained by administering periodic courses of Granulocyte-Colony Stimulating Factor or derivatives. The invention further provides a method for increasing cuticle growth and density using a similar administration of effective consecutive courses of Granulocyte-Colony Stimulating Factor or derivatives. The increased cuticle growth and density is maintained by administering periodic courses of Granulocyte-Colony Stimulating Factor or derivatives.

Abstract: Systems and methods for high-throughput processing of assay plates include a calibration nanoparticle to facilitate automated focusing of the imaging system. An assay plate includes a base layer, a transparent layer in contact with the base layer, and at least one calibration nanoparticle having a pre-defined size immobilized on the assay plate surface. The assay plate surface can be functionalized to selectively bind to biological targets. The assay plate can be used in an imaging system for high-throughput autofocus and biological target detection.