Abstract: Functionalizing a sensor surface with a polydopamine or polynorepinephrine coating covalently bonded to a multi-arm poly(ethylene oxide) that is covalently bonded to a deglycosylated native avidin protein having available biotin binding sites for functionalization with biotinylated aptamers or proteins/peptides that can selectively bind to target biomolecules.

Abstract: The present invention refers to a freeze-dried composition consisting of an isolated microorganism belonging to the Mycobacterium tuberucolosis complex, preferably a M. tuberculos clinical isolate, more preferably M. tuberculosis clinical isolate, characterized in that it comprises a PhoP? phenotype by the inactivation by a genetic deletion of the Rv0757 gene and the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM? phenotype) (the MTBVAC strain), and sucrose and sodium glutamate as stabilizers or excipients. The present invention further refers to the reconstituted composition obtained by adding water, preferably sterilized water for injection, to the freeze-dried composition as well as uses thereof, in particular for use as a prophylactic agent to those at risk of infection with M. tuberulosis or those at risk of developing tuberculosis disease, or as secondary agents for treating infected tuberculosis patients.

Abstract: The invention relates to a coating device and to a method for metal-coating of workpieces, comprising a housing, which surrounds a working space, a retaining apparatus for retaining at least one workpiece in the working space, at least one deposition apparatus comprising a deposition nozzle for applying a metal powder to the workpiece surface to be coated, and a laser for locally melting the metal powder on the workpiece surface to form a coating, and at least one movement apparatus, by means of which the at least one deposition apparatus can be moved relative to the workpiece surface during the coating. Particularly efficient coating is made possible by at least two deposition apparatuses being arranged in the working space in the housing, which apparatuses are designed to simultaneously apply and melt metal powder.

Abstract: Methods and apparatuses are disclosed for communicating a hybrid user equipment with an Internet server, whereby a hybrid access gateway receives a multi-path request from a user plane system, transmits the multipath request toward an Internet server, and receives a corresponding response from the Internet server. If the received response is a single-path response, the hybrid access gateway assumes the Internet server does not support multi-path, activates a proxy function for the session and transmits a multi-path response for the received single-path response toward the user plane system, and the latter marks transmitting further multi-path requests for this session toward the hybrid access gateway.

Abstract: The invention relates to a system (1) for cooling at least one motor vehicle battery (2), this system including: a closed compartment (3) arranged to receive a battery or battery cells (2), a dielectric fluid (4) present in the compartment so that it is able to cool the battery, a cooling device (5) arranged to cool the dielectric fluid, this cooling device including at least one channel in which a heat transfer fluid separate from the dielectric fluid can circulate, this cooling device including at least one inclined face for heat exchange between the dielectric fluid and the heat transfer fluid, this face (110) being arranged inclined relative to a horizontal direction when the system is mounted on the motor vehicle.

Abstract: A toothbrush head and manufacturing method, having a head with bristles that is coupled to a gripping handle, the head having two opposite bases, an outer one and an inner one, which are linked to each other by a central bridge that defines an intermediate separation space therebetween. There are a set of outer bristles and another set of inner bristles, which emerge facing each other from the respective inner faces of the opposite bases, and a set of central bristles emerging from the central bridge and perpendicular to the rest of bristles.

Abstract: The windshield washer fluid dispenser is a self-service station, that is capable of providing a user with high quality windshield washer fluid and the ability to utilize the windshield washer fluid manually. To accomplish this, the device includes a combination of components, that allows one to properly clean the windshield on one's vehicle without the need of an attendant. To accomplish this, the system includes a body, that houses a user-friendly dispenser container, a blend center unit that can instantaneously mix liquids to make a windshield washer solution, and a HID (human interface device) that can dispense the windshield washer solution according to users' needs. Further, the system includes a display device, a payment system, a sign board and necessary accessories that help with the smooth functioning of the system. Thus, the device utilizes simple, user-interactive, and cost-effective technologies to provide the windshield washer fluid dispenser self service station.

Abstract: The invention relates to a coating device and to a method for metal-coating of workpieces, comprising a housing, which surrounds a working space, a retaining apparatus for retaining at least one workpiece in the working space, at least one deposition apparatus comprising a deposition nozzle for applying a metal powder to a workpiece surface to be coated, and a laser for locally melting the metal powder on the workpiece surface to form a coating, at least one movement apparatus, by means of which the at least one deposition apparatus can be moved relative to the workpiece surface during the coating, at least one air supply and at least one air discharge. According to the invention, it is provided that the air supply is arranged in an upper region of the working space above the workpiece and the air discharge is arranged in a lower region of the working space below the workpiece. In addition, a additional suction apparatus is provided with at least one suction opening, which is arranged close to the workpiece.

Abstract: The present invention refers to a freeze-dried composition consisting of an isolated microorganism belonging to the Mycobacterium tuberculosis complex, preferably a M. tuberculosis clinical isolate, more preferably M. tuberculosis clinical isolate, characterized in that it comprises a PhoP? phenotype by the inactivation by a genetic deletion of the Rv0757 gene and the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM? phenotype) (the MTBVAC strain), and sucrose and sodium glutamate as stabilizers or excipients. The present invention further refers to the reconstituted composition obtained by adding water, preferably sterilized water for injection, to the freeze-dried composition as well as uses thereof, in particular for use as a prophylactic agent to those at risk of infection with M. tuberculosis or those at risk of developing tuberculosis disease, or as secondary agents for treating infected tuberculosis patients.

Abstract: The present invention refers to a freeze-dried composition consisting of an isolated microorganism belonging to the Mycobacterium tuberucolosis complex, preferably a M. tuberculos clinical isolate, more preferably M. tuberculosis clinical isolate, characterized in that it comprises a PhoP? phenotype by the inactivation by a genetic deletion of the Rv0757 gene and the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM? phenotype) (the MTBVAC strain), and sucrose and sodium glutamate as stabilizers or excipients. The present invention further refers to the reconstituted composition obtained by adding water, preferably sterilized water for injection, to the freeze-dried composition as well as uses thereof, in particular for use as a prophylactic agent to those at risk of infection with M. tuberulosis or those at risk of developing tuberculosis disease, or as secondary agents for treating infected tuberculosis patients.

Abstract: A system for mounting an acoustic shield above a motor vehicle engine, including a shank having a head and a block of molded elastomer provided with a housing into which the head can be inserted, the housing having a nominal size that allows it to accept, as a close fit, a head of analogous nominal size, the wall of the housing having at least one break in continuity configured as a bellows so that, through deformation of the wall in the region of the break in continuity, the size of the housing can be enlarged to allow it to accept a head of size greater than the nominal size.

Abstract: The present invention is directed to a live-attenuated Mycobacterium tuberculosis composition comprising an isolated microorganism belonging to a M. tuberculosis MTB VAC strain having a i) PhoP? phenotype by the inactivation by a genetic deletion of the Rv0757 gene, wherein the open-reading frame (ORF) sequence of phoP consists of SEQ ID NO 4, and ii) the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM? phenotype), wherein the open-reading frame (ORF) sequence of fadD26 consists of SEQ ID NO 2, for use in therapy in a human subject in need thereof, wherein the composition is administered to said subject via pulmonary delivery.

Abstract: The present invention refers to a freeze-dried composition consisting of an isolated microorganism belonging to the Mycobacterium tuberculosis complex, preferably a M. tuberculosis clinical isolate, more preferably M. tuberculosis clinical isolate, characterized in that it comprises a PhoP? phenotype by the inactivation by a genetic deletion of the Rv0757 gene and the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM? phenotype) (the MTB VAC strain), and sucrose and sodium glutamate as stabilizers or excipients. The present invention further refers to the reconstituted composition obtained by adding water, preferably sterilized water for injection, to the freeze-dried composition as well as uses thereof, in particular for use as a prophylactic agent to those at risk of infection with M. tuberculosis or those at risk of developing tuberculosis disease, or as secondary agents for treating infected tuberculosis patients.

Abstract: The windshield washer fluid dispenser is a self-service station, that is capable of providing a user with high quality windshield washer fluid and the ability to utilize the windshield washer fluid manually. To accomplish this, the device includes a combination of components, that allows one to properly clean the windshield on one's vehicle without the need of an attendant. To accomplish this, the system includes a body, that houses a user-friendly dispenser container, a blend center unit that can instantaneously mix liquids to make a windshield washer solution, and a HID (human interface device) that can dispense the windshield washer solution according to users' needs. Further, the system includes a display device, a payment system, a sign board and necessary accessories that help with the smooth functioning of the system. Thus, the device utilizes simple, user-interactive, and cost-effective technologies to provide the windshield washer fluid dispenser self service station.

Abstract: Devices and methods suitable for cell separation. The devices herein include non-random voids interconnected through non-random pores and/or non-random solid geometrical structures optionally connected through solid non-random interconnecting elements. Such devices are preferably suitable for affinity-based cell isolation techniques which rely upon binding interactions.

Abstract: A method is provided for recording purchase transactions, including: receiving a purchase order request that is associated with a purchase order, the purchase order request being received from a purchaser-side system, the purchase order request including purchase information identifying a product, a product quantity, and a first order identifier that is assigned to the purchase order by the purchaser-side system; generating a transaction document in response to the purchase order request, including the purchase information into the transaction document, and recording the transaction document in a document sharing platform or shared cryptographically protected ledger; and progressively updating the transaction document with information provided by the purchaser-side system and a seller-side system as the purchase order is being fulfilled, wherein each update to the transaction document is recorded in the cryptographically protected ledger.

Abstract: A method can include placing a high intensity focused ultrasound (HIFU) probe proximate a first location of a designated treatment volume of a patient. The probe can include at least one transducer. The method can also include energizing the transducer to ablate a first lesion on or in the designated treatment volume, de-energizing the transducer, and focusing or moving the transducer to a second location on or in the designated treatment volume. The method can also include reenergizing the transducer to ablate a second lesion on or in the treatment volume, de-energizing the transducer, and focusing or moving the transducer to a third location on or in the designated treatment volume. The method can further include reenergizing the transducer to ablate a third lesion on or in the treatment volume, and de-energizing the transducer.

Abstract: The invention relates to a system and to a method for coating workpieces using a coating device, which is designed to apply a metal coating to a surface of the workpiece. According to the invention, it is provided that a plurality of coating devices, which are designed as identical coating modules, are provided and are arranged in a module group, that an input measuring station is assigned to the module group, by means of which station a surface of the face of the workpiece to be coated can be detected, that a conveying apparatus is provided, by means of which a workpiece can be supplied to one of the coating modules from the input measuring station, and that an output measuring station is assigned to the module group, by means of which station a surface of the coated face of the workpiece can be detected.