Abstract: The present invention relates to a solid fosfomycin pharmaceutical composition stable in front the coloration, suitable for diabetics and not entailing gastrointestinal problems. The pharmaceutical composition of this invention comprises fosfomycin trometamol, glycine, and optionally other excipients as sucralose, silice dioxide, polyvinylpyrrolidone and flavor; and is substantially free from sugars and sugar alcohols as sucrose, fructose, glucose, xylitol, mannitol, sorbitol or mixtures thereof.

Abstract: It comprises a compound having antifungal activity as active principle, an inert core and a coating including said active principle, and is characterized in that said inert core has a particle size comprised between 50 and 600 &mgr;m, and in that said coating comprises a single layer obtained by spraying, on said inert core, a solution comprising a compound having antifungal activity, a hydrophilic polymer and a non-ionic surfactant. The method consists in carrying out a coating, comprising a single layer, of the inert cores having a size between 50 and 600 &mgr;m, by means of the spraying of a solution composed by the antifungal agent, the hydrophilic polymer and the non-ionic surfactant, at a constant coating speed throughout the whole process; and a single drying step of said coating in the same apparatus.

Abstract: Disclosed is a pharmaceutical preparation and a process for making the same. The preparation has an inert nucleus; an active layer which is soluble or disintegrates rapidly in water, obtained from a single aqueous or hydroalcoholic solution-suspension which includes: an active ingredient of anti-ulcerous activity of formula I, II or III, and at least one excipient; and a gastro-resistant outer coating layer obtained from a solution which includes an enteric coating polymer and at least one excipient. The process is conducted by coating the inert nuclei by spraying a single aqueous or hydroalcoholic suspension-solution onto the nuclei; drying of the active layer formed during the spraying; and coating the charged nuclei by spraying of a solution which includes an enteric coating polymer with at least one excipient in order to obtain a gastro-resistant outer coating layer.