Abstract: Embodiments of the disclosure encompass methods for generating or expanding a population of immune cells specific for a virus, comprising stimulating immune cells specific for a virus by culturing peripheral blood mononuclear cells (PBMCs) in cell culture medium comprising human platelet lysate in the presence of: (i) one or more peptides corresponding to all or part of one or more antigens of the virus; or (ii) antigen presenting cells (APCs) presenting one or more peptides corresponding to all or part of one or more antigens of the virus. In particular embodiments, the cell culture medium comprises a particular percentage of human platelet lysate and/or the PBMCs are depleted of CD45RA-positive cells, for example.

Abstract: The present disclosure relates to 3-substituted-5-(1-(quinolin-2-yl)piperidin-4-yl)-1,2,4-oxadiazole derivatives for use in the treatment and/or prevention of tuberculosis, the structure the derivatives given by Formula I:

Abstract: A food-receiving container for a household refrigeration appliance includes a shell for receiving food and a ventilation device for carrying out an air exchange between the surroundings and the interior of the food-receiving container. The shell has a front panel on which a handle is disposed. The handle is disposed in an upper region of the front panel, when viewed in the vertical direction of the food-receiving container. The ventilation device is disposed on the handle. A household refrigeration appliance having the food-receiving container is also provided.

Abstract: Omni-directional orthogonally-polarized antenna system for MIMO applications are disclosed herein. An example antenna system comprises two arrays of horizontally polarized radiating elements, and two arrays of vertically polarized radiating elements, each array having roughly 180-degree radiation pattern, disposed about a central axis in a common horizontal plane, arrays of common polarization separated by 180-degrees. Also, the example antenna system includes at least one printed circuit board having a saw tooth pattern, wherein uniform coverage in both vertical and horizontal polarization over 360 degrees is provided using beamforming and polarization diversity.

Abstract: Omni-directional orthogonally-polarized antenna system for MIMO applications are disclosed herein. An example antenna system can have two arrays of horizontally polarized radiating elements, and two arrays of vertically polarized radiating elements, each array having roughly 180-degree radiation pattern, disposed about a central axis in a common horizontal plane, arrays of common polarization separated by 180-degrees, such that MIMO processing of signals to the arrays of common polarization results in a radiation pattern that is substantially constant over 360-degrees in azimuth.

Abstract: A microfluidic die may include a microfluidic passage and a protective layer provided adjacent to internal surfaces of the microfluidic passage. The protective layer may include a protective nano-crystalline material and a protective amorphous matrix encapsulating the protective nano-crystalline material.

Abstract: Treatment and prevention of cancer using virus-specific immune cells, comprising a chimeric antigen receptor (CAR) or nucleic acid encoding a CAR, wherein the CAR comprises: (i) an antigen-binding domain which binds specifically to CD30, (ii) a transmembrane domain, and (iii) a signalling domain, wherein the signalling domain comprises: (a) an amino acid sequence derived from the intracellular domain of CD28, and (b) an amino acid sequence comprising an immunoreceptor tyrosine-based activation motif (ITAM), is disclosed.

Abstract: Omni-directional orthogonally-polarized antenna system for MIMO applications are disclosed herein. An example antenna system can have two arrays of horizontally polarized radiating elements, and two arrays of vertically polarized radiating elements, each array having roughly 180-degree radiation pattern, disposed about a central axis in a common horizontal plane, arrays of common polarization separated by 180-degrees, such that MIMO processing of signals to the arrays of common polarization results in a radiation pattern that is substantially constant over 360-degrees in azimuth.

Abstract: Treatment and prevention of diseases/conditions characterised by an alloreactive immune response using virus-specific immune cells, comprising a chimeric antigen receptor (CAR) or nucleic acid encoding a CAR, wherein the CAR comprises: (i) an antigen-binding domain which binds specifically to CD30, (ii) a transmembrane domain, and (iii) a signalling domain, wherein the signalling domain comprises: (a) an amino acid sequence derived from the intracellular domain of CD28, and (b) an amino acid sequence comprising an immunoreceptor tyrosine-based activation motif (ITAM), is disclosed.

Abstract: Virus-specific immune cells, comprising a chimeric antigen receptor (CAR) or nucleic acid encoding a CAR, wherein the CAR comprises: (i) an antigen-binding domain which binds specifically to CD30, (ii) a transmembrane domain, and (iii) a signalling domain, wherein the signalling domain comprises: (a) an amino acid sequence derived from the intracellular domain of CD28, and (b) an amino acid sequence comprising an immunoreceptor tyrosine-based activation motif (ITAM), are disclosed. Also disclosed are methods for producing and compositions comprising such cells.

Abstract: Omni-directional orthogonally-polarized antenna system for MIMO applications are disclosed herein. An example antenna system can have two arrays of horizontally polarized radiating elements, and two arrays of vertically polarized radiating elements, each array having roughly 180-degree radiation pattern, disposed about a central axis in a common horizontal plane, arrays of common polarization separated by 180-degrees, such that MIMO processing of signals to the arrays of common polarization results in a radiation pattern that is substantially constant over 360-degrees in azimuth.

Abstract: The present disclosure relates to 6-substituted quinoline-2-piperidine derivatives for use in the treatment and/or prevention of tuberculosis.

Abstract: Embodiments of the disclosure concern methods and compositions for immunotherapy for human papillomavirus infection and diseases associated therewith. In specific embodiments, methods concern production of immune cells that target one or more antigens of HPV16 and/or HPV18, including methods with stimulation steps that employ IL-7 and IL-15, but not IL-6 and/or IL-12. Other specific embodiments utilize stimulations in the presence of certain cells, such as costimulatory cells and certain antigen presenting cells.

Abstract: There is provided a method for well construction comprising the steps of: a first phase of the well construction, in which a bottom hole assembly, BHA, with a first drill is used for drilling, and a conductor casing is lowered into the well and cemented; a second phase of the well construction, in which a second drill is used for drilling, wherein a production adapter base, PAB, is installed in parallel with lowering a blowout preventer, BOP; and a third phase of the well construction in which a third drill is used for drilling, for the steps of landing and geonavigation inside a reservoir.

Abstract: Embodiments deal with a method, a computer program as well as an apparatus for detecting one or more objects in the sea floor. The method comprises obtaining a receiver signal. The receiver signal is based on a scattering of multiple acoustic signals at the one or more objects in the sea floor. The receiver signal is generated by a plurality of receivers. The method further comprises grouping portions of the receiver signal to points of a detection grid. The detection grid represents a grid at the points of which the one or more objects are being localized. The method further comprises performing a travel time correction of the portions of the receiver signal with respect to the points of the detection grid. The method further comprises combining the travel time corrected portions of the receiver signal at the points of the detection grid.

Abstract: Omni-directional orthogonally-polarized antenna system for MIMO applications are disclosed herein. An example antenna system can have two arrays of horizontally polarized radiating elements, and two arrays of vertically polarized radiating elements, each array having roughly 180-degree radiation pattern, disposed about a central axis in a common horizontal plane, arrays of common polarization separated by 180-degrees, such that MIMO processing of signals to the arrays of common polarization results in a radiation pattern that is substantially constant over 360-degrees in azimuth.

Abstract: Omni-directional orthogonally-polarized antenna system for MIMO applications are disclosed herein. An example antenna system can have two arrays of horizontally polarized radiating elements, and two arrays of vertically polarized radiating elements, each array having roughly 180-degree radiation pattern, disposed about a central axis in a common horizontal plane, arrays of common polarization separated by 180-degrees, such that MIMO processing of signals to the arrays of common polarization results in a radiation pattern that is substantially constant over 360-degrees in azimuth.