Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Abstract: The invention relates to modulators of activation of Immunoglobulin Superfamily Cell Adhesion Molecules (IgSF CAMs) and modulators of activation of Receptor for Advanced Glycation End Products (RAGE) as well as screening assays for identifying modulators of activation of molecules associated with certain diseases and/or conditions in which IgSF CAMs and/or RAGE are implicated, and to medicaments and methods of treatment comprising administration of such modulators.

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Abstract: A receiving system includes a communication input system to receive a program and a marker file. The program has a total duration when the program is presented in its entirety. The marker file includes a plurality of markers indicating locations of contents-of-interest in the program. The system includes a data storage system to store the program and the marker file. The system includes a user control to receive requests to present the contents-of-interest indicated by the plurality of markers. The system includes one or more processors to determine the locations of the contents-of-interest in the program from the plurality of markers. The system includes a presentation output interface to present the contents-of-interest on a user interface. The presentation of the contents-of-interest skips some content in the program. The contents-of-interest are presented over a shortened duration that is less that a duration of the program when presented in its entirety.

Abstract: A method of screening candidate agents for their ability to modulate RAGE activity where such RAGE activity is induced by an active co-located GPCR, the method comprising the steps of: contacting a RAGE polypeptide with a GPCR polypeptide in the presence of a candidate agent where the GPCR polypeptide is constitutively active and/or is activated by addition of an agonist, partial agonist or allosteric modulator of that GPCR; and detecting whether the candidate agent is a modulator of RAGE ligand-independent activation of RAGE by activated co-located GPCR by detecting an effect indicative of modulation of RAGE activation by the presence of the candidate agent and/or by detecting RAGE-dependent signalling that is modulated by the presence of the candidate agent.

Abstract: A receiving system includes a communication input system to receive a program and a marker file. The program has a total duration when the program is presented in its entirety. The marker file includes a plurality of markers indicating locations of contents-of-interest in the program. The system includes a data storage system to store the program and the marker file. The system includes a user control to receive requests to present the contents-of-interest indicated by the plurality of markers. The system includes one or more processors to determine the locations of the contents-of-interest in the program from the plurality of markers. The system includes a presentation output interface to present the contents-of-interest on a user interface. The presentation of the contents-of-interest skips some content in the program. The contents-of-interest are presented over a shortened duration that is less that a duration of the program when presented in its entirety.

Abstract: A receiving system includes a communication input system to receive a program and a marker file. The program has a total duration when the program is presented in its entirety. The marker file includes a plurality of markers indicating locations of contents-of-interest in the program. The system includes a data storage system to store the program and the marker file. The system includes a user control to receive requests to present the contents-of-interest indicated by the plurality of markers. The system includes one or more processors to determine the locations of the contents-of-interest in the program from the plurality of markers. The system includes a presentation output interface to present the contents-of-interest on a user interface. The presentation of the contents-of-interest skips some content in the program. The contents-of-interest are presented over a shortened duration that is less that the total duration of the program when presented in its entirety.

Abstract: A receiving system includes a communication input system to receive a program and a marker file. The program has a total duration when the program is presented in its entirety. The marker file includes a plurality of markers indicating locations of contents-of-interest in the program. The system includes a data storage system to store the program and the marker file. The system includes a user control to receive requests to present the contents-of-interest indicated by the plurality of markers. The system includes one or more processors to determine the locations of the contents-of-interest in the program from the plurality of markers. The system includes a presentation output interface to present the contents-of-interest on a user interface. The presentation of the contents-of-interest skips some content in the program. The contents-of-interest are presented over a shortened duration that is less that the total duration of the program when presented in its entirety.

Abstract: A communication system and method for minimizing international roaming costs leverages an existing communication network to convert roaming communication sent to and from a mobile telephone into a series of local telephone calls to and from the communication network. Using a universal address, subscribers of the communication system can initiate or participate in real-time communication through the network while roaming outside of a home system, without incurring roaming charges.

Abstract: A communication system and method for minimizing international roaming costs leverages an existing communication network to convert roaming communication sent to and from a mobile telephone into a series of local telephone calls to and from the communication network. Using a universal address, subscribers of the communication system can initiate or participate in real-time communication through the network while roaming outside of a home system, without incurring roaming charges.