Abstract: The non-invasive devices and methods can accurately determine one or more measurements associated with jugular venous pressure while allowing for non-specific placement of (external) sensors. In some examples, the method may include obtaining a set of ECG data from one or more ECG sensors and a set of PPG data from two or more PPG sensors for a patient for a period of time. The method may further include segmenting the PPG data for each PPG sensor using the ECG data. The method may also include determining one or more measurements associated with jugular venous pressure using the segmented PPG data from the two or more PPG sensors.