Abstract: Topical alcoholic or aqueous alcoholic gels containing ibuprofen or other NSAIDs, such as, naproxen, in substantially neutral salt form, have enhanced penetration through skin and may provide rapid pain/inflammation relief by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane or 1,3-dioxane or acetal, as skin penetration enhancing compound. The amount of propylene glycol may be varied to adjust the initial flux of the NSAID through the skin, especially for ibuprofen, naproxen, and ketorolac.

Abstract: A mixture of lipophilic and amphiphilic/hydrophilic film-forming polymers of the formula (I): R(CO).sub.m O--(CH.sub.2 CHR.sup.1 O).sub.n --?OCNH--Z--NHCO.sub.2 (CH.sub.2 CHR.sup.2 O).sub.n' !.sub.p --OCNH--Z--NHCO.sub.2 --(CH.sub.2 CHR.sup.1 O).sub.n --(CO).sub.m R, wherein R represents (i) an alkyl, alkenyl or alkaryl hydrocarbyl group of from 1 to 3 carbon atoms or (ii) a polypropylene oxide group (PPO); R.sup.1 and R.sup.2, each, independently, represent a hydrogen atom, or a methyl or ethyl group; Z represents a divalent linking hydrocarbyl group; m is 0 or 1; n and n', are each, independently, a positive number; and p is >0, preferably p is 0 or 1, provide a skin substantive, occlusive moisture barrier covering for skin or hair. The compositions have a moisturizing effect by reducing transepidermal water loss.

Abstract: A transdermal medication device for applying medication on the skin of the user comprising upper and lower layers having cooperating filaments for detachably securing the upper layer to the lower layer. The lower layer has an opening therethrough, the upper layer carrying a medication reservoir which seats in the opening. In one form of the invention, the device is a patch attached by pressure-sensitive adhesive to the skin. In another form of the invention, the lower layer is a band for attaching the device about the chest, waist, arm or leg of the user.