Abstract: The present invention relates to dispensing instruments and methods for introducing treatment material and fluid-like material with an embryo into a uterus. More specifically, the present invention relates to apparatuses for delivering a fertilized egg or embryo into a maternal uterine endometrium in humans or any other mammalian species and associated computer programs for controlling said apparatuses.

Abstract: The present disclosure provides a method for differentiating myometrial tumors/uterine neoplasms such as LM, LMS and IMT. Further, the disclosure provides a method for treating a uterine leiomyoma in a subject, comprising: (a) performing a genotyping assay on a biological sample from the subject to determine whether the subject has a uterine leiomyosarcoma genotype, and (b) surgically removing the uterine leiomyoma if the subject does not have a uterine leiomyosarcoma genotype.

Abstract: The invention generally relates to the ability of autologous CD133+ bone marrow stem cells (BMDSC) to induce endometrial regeneration and treat endometrial pathologies such as Asherman's syndrome and endometrial atrophy. Methods to induce endometrial regeneration are provided, which comprises administering an effective amount of autologous CD133+ bone marrow derived stem cells (BMDSC) into uterine arteries of a subject in need thereof to induce endometrial regeneration.

Abstract: The present Application provides in one aspect a method of diagnosing a menstrual cycle event in a subject (e.g., a WOI), comprising detecting in a biological sample a gene signature for one or more endometrial cell types (e.g., unciliated epithelial cells). The present Application in another aspect provides a method comprising determining a gene expression profile in each of a plurality of endometrial cells, wherein said endometrial cells are: (a) in an endometrial sample obtained from a subject, and (b) unciliated epithelial cells.

Abstract: The invention concerns a turbine for a gas turbine comprising a blade, a vane and an abradable lip attached to the blade or to the vane, wherein the blade and the vane are separated by a gap and the abradable lip extends part of the distance across the gap. Embodiments include the addition of an abrasive layer attached on the other side of the gap from the abradable lip. A method of manufacturing is also described.

Abstract: Provided herein, in some embodiments, are methods and compositions for detecting differentially expressed genes in a sample obtained from a subject having or at risk for preeclampsia.

Abstract: A method is disclosed for cooling a gas turbine having a turbine, wherein a rotor, which rotates about a machine axis, carries a plurality of rotating blades, which are mounted by blade roots and extend with their airfoils into a hot gas path of the gas turbine. The rotor is concentrically surrounded by a turbine vane carrier carrying a plurality of stationary vanes, whereby the rotating blades and the stationary vanes are arranged in alternating rows in axial direction. An extended lifetime with external cooling is achieved by providing first and second cooling systems for the turbine.

Abstract: The present invention relates to determining the receptivity of human endometrium from a gene expression profile. More specifically, the invention consists of developing a specific expression microarray of endometrial receptivity (Endometrial Receptivity Array or ERA) which allows evaluating the receptive state of a human endometrium, as well as assessing said state for diagnostic and therapeutic purposes.

Abstract: The present disclosure generally relates to a rotor assembly, and in particular relates to an improved rotor heat shield which provides an innovative configuration for securing the same to the rotor assembly. The rotor heat shield element is secured to the rotor assembly in correspondence of the groove in which it is inserted. Embodiments of the present disclosure can allow the removal of current fixation features on heat shields and blades. Furthermore, since the heat shield is no longer connected to a blade but directly to the rotor assembly, there is more freedom in selecting the number of heat shield elements to be provided to form the circumferential heat shield.

Abstract: The invention relates to a rotor shaft adapted to rotate about a rotor axis thereof. The rotor shaft includes a rotor cavity configured concentrically or quasi-concentrically to the rotor axis inside the rotor shaft, and a plurality of cooling bores extending radially or quasi-radially outward from the inside to an outside of the rotor shaft. Each cooling bore having a bore inlet location and a distal bore outlet portion, the respective bore inlet location being adapted to abut on the rotor cavity. At least one side or part-side of the cooling bore inlet location is provided with an asymmetric edge fillet in order to maximize the wall thickness between two adjacent cooling bores.

Abstract: The present invention relates to determining the receptivity of human endometrium from a gene expression profile. More specifically, the invention consists of developing a specific expression microarray of endometrial receptivity (Endometrial Receptivity Array or ERA) which allows evaluating the receptive state of a human endometrium, as well as assessing said state for diagnostic and therapeutic purposes.

Abstract: The invention pertains to a seal system for a passage between a turbine stator and a turbine rotor, including: a first arm extending radially outwards from the turbine rotor and toward the first seal arranged on the stator, and terminating short of the first seal thereby creating a first gap between the first seal and the first arm. The seal system further includes a second seal arranged on the turbine stator, and a second arm extending axially from the turbine rotor towards the second seal base, and terminating short of the second seal thereby creating a second gap between the second seal and the second arm. The invention further refers to a gas turbine including such a seal system.

Abstract: The present invention relates to a rotor assembly for a rotary machine such as a gas turbine. The present solution provides a sealing wire located inside a groove engraved in the rotor body. The sealing wire is responsive to radial centrifugal forces acting during normal operation of the machine, and moves radially in the groove until a sealing configuration is achieved such to prevent damaging hot leakage towards machine components.

Abstract: The disclosure pertains to a turbine with a gas turbine blade and a rotor heat shield for separating a space region through which hot working medium flows from a space region inside a rotor arrangement of the turbine. The rotor heat shield includes a platform which forms an axial heat shield section and which is arranged substantially parallel to the surface of a rotor and a radial heat shield section at the upstream end of the axial heat shield section, which is extending in a direction away from the surface of the axial heat shield section towards the hot gas. Further the turbine comprises a blade rear cavity which is delimited by the downstream end of the platform and/or the downstream end of the blade foot, the radial heat shield section. The disclosure further refers to a gas turbine blade and a rotor heat shield designed for such a turbine.

Abstract: A method and a cooling system for cooling blades of at least one blade row in a rotary flow machine includes an axial flow channel which is radially limited on the inside by a rotor unit and at the outside by at least one stationary component, the blades are arranged at the rotary unit and provide a shrouded blade tip facing radially to said stationary component. Pressurized cooling air is fed through from radially outside towards the tip of each of said blades in the at least one blade row, and the pressurized cooling air enters the blades through at least one opening at the shrouded blades' tip.

Abstract: A gas turbine is disclosed which includes a compressor, a combustor downstream of the compressor, a turbine downstream of the combustor, a heat exchanger, a first cooling fluid system and a second cooling fluid system. The first and the second cooling fluid systems are each configured and arranged to extract a cooling fluid from the compressor and to cool a part of the gas turbine using the cooling fluid. The first and the second cooling fluid systems each extend from the compressor to the heat exchanger and from the heat exchanger to the part of the gas turbine to be cooled. The heat exchanger can exchange heat from the cooling fluid in the second cooling fluid system to the cooling fluid in the first cooling fluid system. A rotor cover with a heat exchanger and methods of operation are also described.

Abstract: A gas turbine is provided and includes a compressor, which via an air intake inducts and compresses air; a combustion chamber, in which a fuel is combusted using the compressed air, producing a hot gas; and a turbine, equipped with turbine blades, in which the hot gas is expanded, performing work. A first device is provided in order to cool turbine blades with compressed cooling air. The first device includes at least one separate compressor stage which produces compressed cooling air independently of the compressor.

Abstract: A labyrinth seal is provided for sealing the annular interspace between the rotor and the stator of a steam turbine or gas turbine. The labyrinth seal includes a multiplicity of sealing strips which are arranged in series in the axial direction and fastened on the stator and project into the interspace. The sealing strips interact, with sealing effect, with rotor-side sealing elements which are arranged in a staggered manner. An improved sealing effect is achieved by the sealing strips in the cold installed state being offset in relation to a symmetrical position, wherein the offset has the reverse direction and the same amount as the distance by which the sealing strip is displaced relative to adjacent rotor-side sealing elements as a result of thermal expansions of the stationary and rotating components and support structure when being heated from the cold installed state to a hot steady-state operating condition.

Abstract: The invention generally relates to the ability of autologous CD133+ bone marrow stem cells (BMDSC) to induce endometrial regeneration and treat endometrial pathologies such as Asherman's syndrome and endometrial atrophy. Methods to induce endometrial regeneration are provided, which comprises administering an effective amount of autologous CD133+ bone marrow derived stem cells (BMDSC) into uterine arteries of a subject in need thereof to induce endometrial regeneration.

Abstract: The invention provides non-invasive assays to reliably identify women who have or are predisposed to developing preeclampsia (PE). The method comprises measuring a level of annexin A2 (ANXA2) in a test sample obtained of a subject; and identifying the subject as having preeclampsia or at an increased risk of developing preeclampsia when the level of ANXA2 in the test sample is decreased in relation to a control sample. Methods to treat subject identified as having PE or at an increased risk of developing preeclampsia are also provided.