Patents by Inventor Carlos Simmerling

Carlos Simmerling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITION AND METHOD TO STABILIZE CORONAVIRUS SPIKE GLYCOPROTEINS IN PRE-FUSION CONFORMATION
    Publication number: 20230357325
    Abstract: Compositions include coronavirus S1/S2 prefusion spike proteins with specifically designed disulfide bond that “staple” together the central helix and a region of the spike known as HR1. By preventing HR1 from detaching from CH, the prefusion spike structure is stabilized without rigidification of the central helix or changes to its interaction with the receptor binding domain. This disulfide-stapled spike is more stable in the prefusion form, allowing for a stable vaccine without the need for the stabilizing mutations that are currently in use.
    Type: Application
    Filed: May 9, 2023
    Publication date: November 9, 2023
    Inventor: Carlos Simmerling