Abstract: The present disclosure related to methods to treat, prevent (e.g., suppress, inhibit or delay), or ameliorate the symptoms of a TLR-4 mediated disease or condition comprising administering an aptamer of the present disclosure to a subject in need thereof, alone or combination with other pharmacological and/or surgical interventions. In a particular aspect, the aptamers of the present disclosure are administered before, during, or after pharmacological and/or surgical interventions (e.g., thrombolysis such as thrombectomy) or any combination thereof, for the treatment of ischemic (e.g., myocardial infarction or ischemic stroke), hemorrhagic (e.g., hemorrhagic stroke or hemorrhagic transformation), or neurodegenerative (e.g., multiple sclerosis) diseases or conditions. The disclosure also provides specific doses and dosage regimes.

Abstract: Biodegradable mulch of the type used in various agricultural applications is made by multi-layer extrusion from a mixture of two compostable biodegradable polymers that comply with the EN13432 standard and that include potato starch, a black masterbatch and biodegradable recycled polymers. The mulch self-degrades in a short period of time, becoming a compostable material that enriches the soil, avoiding the collecting and cleaning tasks that are necessary in conventional mulches.

Abstract: The present invention relates to the use of an Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) inhibitor for preventing and/or treating cardiac damage arising after an ischemic process followed by reperfusion. The authors of the present invention have observed that EMMPRIN expression increases in subjects who have suffered ischemia/reperfusion, ascertaining that an EMMPRIN inhibitor is capable of reducing the cardiac damage caused after ischemia followed by reperfusion, both in vitro and in vivo.

Abstract: Biodegradable mulch of the type used in various agricultural applications is made by multi-layer extrusion from a mixture of two compostable biodegradable polymers that comply with the EN13432 standard and that include potato starch, a black masterbatch and biodegradable recycled polymers. The mulch self-degrades in a short period of time, becoming a compostable material that enriches the soil, avoiding the collecting and cleaning tasks that are necessary in conventional mulches.

Abstract: The present invention relates to the use of an EMMPRIN inhibitor for preventing and/or treating cardiac damage arising after an ischemic process followed by reperfusion. The authors of the present invention have observed that EMMPRIN expression increases in subjects who have suffered ischemia/reperfusion, ascertaining that an EMMPRIN inhibitor is capable of reducing the cardiac damage caused after ischemia followed by reperfusion, both in vitro and in vivo.