Patents by Inventor Carlos Zarate
Carlos Zarate has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230192594Abstract: The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketam-ine (HNK) includes preparation of (R)-norket-amine via chiral resolution from racemic norketamine via a chiral resolution with L-pyro-glutamic acid. The disclosure also provided crystal forms of the corresponding (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hy-droxynorketamine hydrochloride salts.Type: ApplicationFiled: February 16, 2023Publication date: June 22, 2023Inventors: Craig Thomas, Carlos Zarate, Ruin Moaddel, Todd Gould, Panos Zanos, Patrick Morris
-
Patent number: 11613514Abstract: The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketamine (HNK) includes preparation of (R)-norketamine via chiral resolution from racemic norketamine via a chiral resolution with L-pyroglutamic acid. The disclosure also provided crystal forms of the corresponding (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine hydrochloride salts.Type: GrantFiled: January 22, 2021Date of Patent: March 28, 2023Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICESInventors: Craig Thomas, Carlos Zarate, Ruin Moaddel, Todd Gould, Panos Zanos, Patrick Morris
-
Publication number: 20230022767Abstract: The disclosure provides salts of (2R,6R)-hydroxynorketamine (HNK), wherein the salt is with an organic acid chosen from malonic acid, salicylic acid, ethane sulfonic acid, glycolic acid, stearic acid, or capric acid, and their crystal forms.Type: ApplicationFiled: November 17, 2020Publication date: January 26, 2023Inventors: Patrick Joseph Morris, Craig Joseph Thomas, Stephen J. Byard, Martin P. Wilmshurst, Todd Gould, Carlos Zarate, Ruin Moaddel
-
Publication number: 20210139411Abstract: The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketamine (HNK) includes preparation of (R)-norketamine via chiral resolution from racemic norketamine via a chiral resolution with L-pyroglutamic acid. The disclosure also provided crystal forms of the corresponding (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine hydrochloride salts.Type: ApplicationFiled: January 22, 2021Publication date: May 13, 2021Inventors: Craig Thomas, Carlos Zarate, Ruin Moaddel, Todd Gould, Panos Zanos, Patrick Morris
-
Patent number: 10919842Abstract: The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketamine (HNK) includes preparation of (R)-norketamine via chiral resolution from racemic norketamine via a chiral resolution with L-pyroglutamic acid. The disclosure also provided crystal forms of the corresponding (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine hydrochloride salts.Type: GrantFiled: March 27, 2017Date of Patent: February 16, 2021Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICESInventors: Craig Thomas, Carlos Zarate, Ruin Moaddel, Todd Gould, Panos Zanos, Patrick Morris
-
Publication number: 20190135732Abstract: The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketamine (HNK) includes preparation of (R)-norketamine via chiral resolution from racemic norketamine via a chiral resolution with L-pyroglutamic acid. The disclosure also provided crystal forms of the corresponding (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine hydrochloride salts.Type: ApplicationFiled: March 27, 2017Publication date: May 9, 2019Inventors: Craig Thomas, Carlos Zarate, Ruin Moaddel, Todd Gould, Panos Zanos, Patrick Morris
-
Publication number: 20190083420Abstract: Disclosed is a method of treating Psychotic Depression, Suicidal Ideation, Disruptive Mood Dysregulation Disorder, Persistent Depressive Disorder (Dysthymia), Premenstrual Dysphoric Disorder, Substance/Medication-Induced Depressive Disorder, Depressive Disorder Due to Another Medical Condition, Other Specified Depressive Disorder, Unspecified Depressive Disorder, Separation Anxiety Disorder, Selective Mutism, Specific Phobia, Social Anxiety Disorder (Social Phobia), Panic Disorder, Panic Attack (Specifier), Agoraphobia, Generalized Anxiety Disorder, Substance/Medication-Induced Anxiety Disorder, Anxiety Disorder Due to Another Medical, Other Specified Anxiety Disorder, Unspecified Anxiety Disorder, or fatigue the method including administering a pharmaceutical composition containing an effective amount of an active agent, wherein the active agent is purified (2R,6R)-hydroxynorketamine, purified (2S,6S)-hydroxynorketamine, or a combination thereof, or a pharmaceutically acceptable salt thereof, together with aType: ApplicationFiled: March 27, 2017Publication date: March 21, 2019Inventors: Irving Wainer, Carlos Zarate, Ruin Moaddel, Todd Gould, Panos Zanos, Craig Thomas, Patrick Morris
-
Patent number: 9373158Abstract: The present invention relates to a system and method for reducing image artifacts for a CMOS camera used as an optical detector for a line confocal fluorescent imager. The method for reducing image artifacts in a monochromatic image comprises subtracting RGB channel offset mismatch; and correcting random row offset for each row. Preferably, the method also comprises correcting random column offset and gain. Optionally, the method also comprises clipping of defective pixels, and/or subtracting dark current. When the monochromatic image is a fluorescence image, the method also comprises a step of compressing CMOS camera noise. Also provided are a system for reducing image artifacts in a monochromatic image from a CMOS camera, as well as an image artifact reduction system for a CMOS camera-based line confocal fluorescent microscope.Type: GrantFiled: July 19, 2011Date of Patent: June 21, 2016Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Pavel A. Fomitchov, Witold Bula, Carlos Zarate, Yang Zhang
-
Patent number: 9057701Abstract: A system for performing automated cell screening in drug discovery, includes an automated microscope, a fast autofocus device, and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.Type: GrantFiled: June 17, 2010Date of Patent: June 16, 2015Assignee: GE HEALTHCARE NIAGARA INC.Inventors: Peter Ramm, Yuriy Alexandrov, Paul Donders, Carlos Zarate, Bohdan J. Soltys
-
Publication number: 20130129212Abstract: The present invention relates to a system and method for reducing image artifacts for a CMOS camera used as an optical detector for a line confocal fluorescent imager. The method for reducing image artifacts in a monochromatic image comprises subtracting RGB channel offset mismatch; and correcting random row offset for each row. Preferably, the method also comprises correcting random column offset and gain. Optionally, the method also comprises clipping of defective pixels, and/or subtracting dark current. When the monochromatic image is a fluorescence image, the method also comprises a step of compressing CMOS camera noise. Also provided are a system for reducing image artifacts in a monochromatic image from a CMOS camera, as well as an image artifact reduction system for a CMOS camera-based line confocal fluorescent microscope.Type: ApplicationFiled: July 19, 2011Publication date: May 23, 2013Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Pavel A. Fomitchov, Witold Bula, Carlos Zarate, Yang Zhang
-
Patent number: 8253263Abstract: A wave energy conversion system or device includes a float and base on top of which there is a power take-off system. The float, its base and the machine room are inserted in a main column supported by legs and corresponding leg supports on the bottom floor in shallow waters (seas or lakes). In deeper waters, the main column may be supported by column supports attached to an underwater float. The machine room is separated of the float frame through a rotary joint which allows the float and base to rotate in any horizontal direction while maintaining the machine room fixed in the same horizontal direction. The rotary joint separating the float frame and the machine room also allows for the vertical up and down movement when interacting with incoming waves. The distance between the machine room and the float frame is always the same. The device includes flaps or blades for the absorption of kinetic energy derived from the back and forth movement of water generated by waves.Type: GrantFiled: April 24, 2009Date of Patent: August 28, 2012Inventors: Alvaro Atilano, Carlos Zarate, Jaime Zarate, Mario Favaretto, Felix Tovar, Rafael Uzcategui
-
Patent number: 7764822Abstract: A system for performing automated cell screening in drug discovery, includes an automated microscope, a fast autofocus device, and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.Type: GrantFiled: October 17, 2008Date of Patent: July 27, 2010Assignee: GE Healthcare Niagara Inc.Inventors: Peter Ramm, Yuriy Alexandrov, Jurich Cybuch, Paul Donders, Carlos Zarate, Bohdan Soltys
-
Publication number: 20090074283Abstract: A system for performing automated cell screening in drug discovery, includes an automated microscope, a fast autofocus device, and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.Type: ApplicationFiled: October 17, 2008Publication date: March 19, 2009Applicant: GE HEALTHCARE NIAGARA INC.Inventors: PETER RAMM, Yuriy Alexandrov, Jurich Cybuch, Paul Donders, Carlos Zarate, Bohdan J. Soltys
-
Patent number: 7469056Abstract: A system for performing automated cell screening in drug discovery, including an automated microscope, a fast autofocus device and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.Type: GrantFiled: May 9, 2003Date of Patent: December 23, 2008Assignee: GE Healthcare Niagara Inc.Inventors: Peter Ramm, Yuriy Alexandrov, Jurich Cybuch, Paul Donders, Carlos Zarate, Bohdan J. Soltys
-
Patent number: 7335898Abstract: A new and improved confocal fluorescence microscope is presented. The new microscope has significant advantages relative to existing implementations of microscope confocal imagers. In common with previous confocal imagers the instant invention has the advantages relative to conventional wide-field and confocal fluorescence imagers, however it addresses the drawbacks of confocal technology in terms of cost and complexity, and provides significant savings in both due to the simplicity of the components and the elimination of the need of, in particular, spatial filters such as pinholes or slits.Type: GrantFiled: July 19, 2005Date of Patent: February 26, 2008Assignee: GE Healthcare Niagara Inc.Inventors: Paul Donders, Carlos Zarate, Pavel A. Fomitchov
-
Publication number: 20070287753Abstract: Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent or chronic depressive symptoms (>2 years).Type: ApplicationFiled: March 20, 2007Publication date: December 13, 2007Applicants: MOUNT SINAI SCHOOL OF MEDICINE, NATIONAL INSTITUTE OF HEALTH, YALE UNIVERSITY SCHOOL OF MEDICINEInventors: Dennis Charney, Sanjay Mathew, Husseini Manji, Carlos Zarate, John Krystal
-
Publication number: 20060257013Abstract: A system for performing automated cell screening in drug discovery, including an automated microscope, a fast autofocus device and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.Type: ApplicationFiled: May 9, 2003Publication date: November 16, 2006Inventors: Peter Ramm, Yuriy Alexandrov, Jurich Cybuch, Paul Donders, Carlos Zarate, Bohdan Soltys
-
Publication number: 20060017001Abstract: A new and improved confocal fluorescence microscope is presented. The new microscope has significant advantages relative to existing implementations of microscope confocal imagers. In common with previous confocal imagers the instant invention has the advantages relative to conventional wide-field and confocal fluorescence imagers, however it addresses the drawbacks of confocal technology in terms of cost and complexity, and provides significant savings in both due to the simplicity of the components and the elimination of the need of, in particular, spatial filters such as pinholes or slits.Type: ApplicationFiled: July 19, 2005Publication date: January 26, 2006Inventors: Paul Donders, Carlos Zarate, Pavel Fomitchov
-
Patent number: 6806455Abstract: The present invention relates to an apparatus and method for imaging time resolved fluorescence in biochemical and medical samples. In a primary aspect, the device includes a lens of large aperture, a flash lamp in the illumination path, a fast-acting solid state shutter or a gated detector in the emission path, a device for delivering homogenous monochromatic illumination to a plurality of wells distributed within a microwell plate, a digital camera of high quantum efficiency, and a computer under computer control, the lamp is pulsed at short intervals. The fast-acting emission shutter or gated detector operates to limit exposure of the camera to a period some microseconds after the extinction of each lamp pulse, during which only delayed fluorescence is transmitted to the camera. The invention achieves simultaneous time resolved imaging of a plurality of samples, with high sensitivity and high throughput.Type: GrantFiled: September 30, 2002Date of Patent: October 19, 2004Assignee: Imaging Research Inc.Inventors: Carlos Zarate, Paul Donders, Ahmad Yekta, Zahra Masoumi, Peter Ramm
-
Publication number: 20030160151Abstract: The present invention relates to an apparatus and method for imaging time resolved fluorescence in biochemical and medical samples. In a primary aspect, the device includes a lens of large aperture, a flash lamp in the illumination path, a fast-acting solid state shutter or a gated detector in the emission path, a device for delivering homogenous monochromatic illumination to a plurality of wells distributed within a microwell plate, a digital camera of high quantum efficiency, and a computer under computer control, the lamp is pulsed at short intervals. The fast-acting emission shutter or gated detector operates to limit exposure of the camera to a period some microseconds after the extinction of each lamp pulse, during which only delayed fluorescence is transmitted to the camera. The invention achieves simultaneous time resolved imaging of a plurality of samples, with high sensitivity and high throughput.Type: ApplicationFiled: September 30, 2002Publication date: August 28, 2003Inventors: Carlos Zarate, Paul Donders, Ahmad Yekta, Zahra Masoumi, Peter Ramm