Patents by Inventor Carlotta Spano

Carlotta Spano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR THE PRODUCTION OF BI-FUNCTIONAL CELLS TO TREAT NEOPLASIA
    Publication number: 20210300990
    Abstract: Method for the production of bi-functional cells comprising engineering a starting cell population with a phenotype attributable to human pericytes extracted from adipose tissue (AD-PC), obtaining engineered cells, known as bi-functional AD-PCs, expressing (which means that they produce) simultaneously both the anti-tumor molecule TRAIL and also the truncated form of a chimeric receptor targeted against the GD2 antigen (GD2 tCAR); this dual targeting (understood as reaching a specific target), based on affinity and mediated by both TRAIL and also GD2 tCAR, supports the prediction of combining site-specificity with a prolonged retention of AD-PCs in tumors expressing the antigen GD2, so as to achieve a more effective release of TRAIL for still incurable tumors.
    Type: Application
    Filed: July 30, 2019
    Publication date: September 30, 2021
    Inventors: Giulia Golinelli, Giulia Grisendi, Carlotta Spano, Olivia Candini, Massimo Dominici
  • METHOD TO PRODUCE CONDITIONALLY APOPTOTIC CELLS
    Publication number: 20210214689
    Abstract: The method to produce conditionally apoptotic cells comprises modifying a cell population with a phenotype attributable to human adipose tissue-derived pericytes (AD-PC) expressing anti-tumor TRAIL introducing a sequence coding a conditional suicide gene (CSG).
    Type: Application
    Filed: May 31, 2019
    Publication date: July 15, 2021
    Inventors: Filippo Rossignoli, Carlotta Spano, Giulia Grisendi, Olivia Candini, Massimo Dominici
  • METHOD FOR THE PRODUCTION OF CELLULAR PARTICULATE WITH ANTITUMOR ACTIVITY
    Publication number: 20210054339
    Abstract: Method for the production of cellular particulate with antitumor activity, which comprises isolating the cellular particulate originating from a cell population with a phenotype that can be attributed to human adipose tissue derived pericytes (AD-PC) that express antitumor TRAIL.
    Type: Application
    Filed: April 24, 2019
    Publication date: February 25, 2021
    Inventors: Filippo Rossignoli, Carlotta Spano, Giulia Grisendi, Olivia Candini, Massimo Dominici
  • Modified effector cell (or chimeric receptor) for treating disialoganglioside G-expressing neoplasia
    Patent number: 10647997
    Abstract: A modified effector cell includes a non-reversibly produced vector-encoded anti-GD2-BB-? chimeric receptor for use in disialoganglioside GD2-expressing neoplasia, which is inserted in the cell, to obtain an effector cell that stably produces the anti-GD2-BB-? chimeric receptor, the chimeric receptor having two distinct mutually fused portions, i.e. an intra-cytoplasmic portion and an extra-cytoplasmic portion.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: May 12, 2020
    Assignee: St. Jude Children's Research Hospital, Inc.
    Inventors: Massimo Dominici, Sara Caldrer, Maria Carlotta Spano, Paolo Paolucci, Marco Bestagno, Dario Campana
  • Modified Effector Cell (or Chimeric Receptor) for Treating Disialoganglioside GD2-Expressing Neoplasia
    Publication number: 20140302608
    Abstract: A modified effector cell includes a non-reversibly produced vector-encoded anti-GD2-BB-? chimeric receptor for use in disialoganglioside GD2-expressing neoplasia, which is inserted in the cell, to obtain an effector cell that stably produces the anti-GD2-BB-? chimeric receptor, the chimeric receptor having two distinct mutually fused portions, i.e. an intra-cytoplasmic portion and an extra-cytoplasmic portion.
    Type: Application
    Filed: October 25, 2012
    Publication date: October 9, 2014
    Inventors: Massimo Dominici, Sara Caldrer, Maria Carlotta Spano, Paolo Paolucci, Marco Bestagno, Dario Campana