Abstract: The present invention relates to a Bicycle toxin conjugate BT5528, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof, and uses thereof.

Abstract: The present disclosure provides methods for the treatment of a cancer characterized by at least one tumor comprising intratumoral B cells and/or stromal B cells, in a subject, comprising administering to the subject an EZH2 inhibitor. The present disclosure also provides methods of identifying a subject having cancer for treatment with an EZH2 inhibitor of determining the response of a subject to an EZH2-inhibitor therapy, the methods comprising determining the level of intratumoral B cells and/or stromal B cells. The present disclosure also provides a method of decreasing the number and/or density of intratumoral B cells and/or stromal B cells in a tumor in a subject, comprising administering to the subject an EZH2 inhibitor.