Patents by Inventor Carmel M. Lynch

Carmel M. Lynch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods, compositions, and cells for encapsidating recombinant vectors in AAV particles
    Patent number: 6893865
    Abstract: Isolated recombinant polynucleotides comprising elements which promote encapsidation into AAV particles, packaging cells comprising the recombinant polynucleotides, and methods for their use are provided in the present invention. These isolated recombinant polynucleotides comprise a non-AAV ITR encapsidation element (such as the P1 sequence located within the AAV S1 integration site of human chromosome 19) operably linked to one or more heterologous genes to be encapsidated. The constructs may be either integrated into a mammalian cell genome, maintained episomally, or provided transiently.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: May 17, 2005
    Assignee: Targeted Genetics Corporation
    Inventors: Dara H. Lockert, Carmel M. Lynch, Haim Burstein, Anthony M. Stephan
  • Amplifiable adeno-associated virus(AAV) packaging cassettes for the production of recombinant AAV vectors
    Patent number: 6642051
    Abstract: High-efficiency AAV packaging constructs and methods for their use are provided. in the present invention. These high-efficiency packaging constructs comprise an activating element (such as the P1 sequence located within the AAV S1 integration site of human chromosome 19) amplifiably linked to one or more AAV packaging genes. The constructs may be either integrated into a mammalian cell genome or maintained episomally. Use of the high-efficiency AAV packaging vectors of the invention provides for controlled amplifiable production of rAAV vector constructs.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: November 4, 2003
    Assignee: Targeted Genetics Corporation
    Inventors: Carmel M. Lynch, Haim Burstein, Anthony M. Stepan, Dara H. Lockert
  • Methods for transducing cells in blood vessels using recombinant AAV vectors
    Publication number: 20020001581
    Abstract: Current techniques for expressing recombinant genes in cells of blood vessels following direct in vivo gene transfer are limited by attendant problems or limitations. Further, an effective method of transducing microvascular cells and/or cells involved in formation of new blood vessels (angiogenesis) has not been demonstrated. This invention provides methods of transducing cells in blood vessels using recombinant adeno-associated virus (AAV) vectors.
    Type: Application
    Filed: August 23, 2001
    Publication date: January 3, 2002
    Inventors: Carmel M. Lynch, Randolph L. Geary