Patents by Inventor Carmela R. Abraham

Carmela R. Abraham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5849560
    Abstract: A proteolytic factor has been isolated from the brains of humans with Alzheimer's disease which specifically cleaves the peptide having the sequence His-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe (SEQ ID NO: 1) between Met and Asp. This peptide is in the cleavage site of the N-terminal domain of the amyloid .beta.-protein precursor.
    Type: Grant
    Filed: February 26, 1993
    Date of Patent: December 15, 1998
    Assignee: Trustees of Boston University
    Inventor: Carmela R. Abraham
  • Patent number: 5200339
    Abstract: A proteolytic factor is capable of cleaving .beta.-protein precursor at a site near the .beta.-protein N-terminus. Also, a method for treating Alzheimer's disease in a patient includes steps of reducing .beta.-protein precursor proteolysis outside the .beta.-protein domain at a site near the .beta.-protein N-terminus. Also, a method for purifying an enzyme from a sample includes steps of incubating the sample with a labelled substrate of the enzyme or with a labelled fragment of a substrate to which the enzyme binds, treating the sample with a crosslinking agent to crosslink any enzyme-substrate complexes in the sample, and recovering labelled complexes. Also, a method for diagnosis in a subject of a disease characterized by accumulation of amyloid includes determining the level, in a sample of tissue or body fluid from the subject, of an AD proteolytic factor.
    Type: Grant
    Filed: April 5, 1991
    Date of Patent: April 6, 1993
    Inventor: Carmela R. Abraham