Abstract: The present invention relates to novel protozoal cyclic GMP dependent protein kinases and genes encoding same that have been isolated from Eimeria maxima and Plasmodium falciparum. Nucleic acid molecules having sequences that encode such proteins as well as antibodies raised against such proteins are also disclosed. These enzymes may be used in screening assays to identify potential antiprotozoal agents. As well, methods to obtain such nucleic acid molecules, proteins, antibodies and inhibitor are also provided as are therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasites such as Eimeria maxima and Plasmodium falciparum.

Abstract: The present invention relates to novel protozoal cyclic GMP dependent protein kinases and genes encoding same that have been isolated from Eimeria maxima and Plasmodium falciparum. Nucleic acid molecules having sequences that encode such proteins as well as antibodies raised against such proteins are also disclosed. These enzymes may be used in screening assays to identify potential antiprotozoal agents. As well, methods to obtain such nucleic acid molecules, proteins, antibodies and inhibitor are also provided as are therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasites such as Eimeria maxima and Plasmodium falciparum.

Abstract: Apparatus and method for detecting a protein in a sample, such as a sample flushed through a food processing system. If the sample or food processing system contains the protein in detectable amounts, a test membrane will change color. The invention thus provides a simple semi-quantitative test for the presence of a protein.

Abstract: Catheters including a rugged, reusable proximal body and a disposable distal body attached by a releasable connection are provided. The reusable proximal body is constructed from resterilizable materials such as glass, metal alloys and engineering plastics. The disposable distal body, designed for one-time use, is made from reliable but inexpensive materials. The catheters may be dilatation catheters and may be manufactured in any configuration, including rapid exchange, balloon-on-a-wire, and over-the-wire designs with single or multiple lumens. The modular construction of the catheter and releasable connection provides for rapid and easy changes in the configuration and balloon size depending on the needs of the medical procedure.

Abstract: Disclosed is an everting balloon catheter in which the balloon has a waist at the desired eversion point to minimize the size of the distal tip of the catheter during insertion. Preferably, the distal end of the outer body is bevelled and the waist is located just distal and radial to the tip of the outer body when the inner body is fully extended distal to the outer body. Usually, the waist is formed by heat shrinking the balloon during manufacture, thus usually increasing balloon thickness at the waist.Also, in the disclosed invention, the balloon is attached to the outer catheter bod via heat fusion. Generally, the outer body and the balloon are both formed of compositions having at least one component in common to promote heat fusion for attachment of the balloon. Preferably that component is polyethylene.