Patents by Inventor Carmen J. Allegra

Carmen J. Allegra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for treating neoplasia
    Patent number: 8501242
    Abstract: The present invention relates to compounds as novel thymidylate synthase inhibitors, novel strategies to treat or prevent neoplasia in a subject, methods and compositions thereof.
    Type: Grant
    Filed: May 29, 2010
    Date of Patent: August 6, 2013
    Assignee: University of Florida Research Foundation
    Inventors: David A. Ostrov, Carmen J. Allegra
  • METHODS AND COMPOSITIONS FOR TREATING NEOPLASIA
    Publication number: 20120156212
    Abstract: The present invention relates to compounds as novel thymidylate synthase inhibitors, novel strategies to treat or prevent neoplasia in a subject, methods and compositions thereof.
    Type: Application
    Filed: May 29, 2010
    Publication date: June 21, 2012
    Inventors: David A. Ostrov, Carmen J. Allegra
  • METHODS FOR DETERMINING THE PROGNOSIS OF BREAST CANCER USING ANTIBODIES SPECIFIC FOR THYMIDYLATE SYNTHASE
    Publication number: 20020090642
    Abstract: Methods for determining the prognosis of a patient afflicted with breast cancer, comprising;
    Type: Application
    Filed: September 14, 1998
    Publication date: July 11, 2002
    Inventors: PATRICK G. JOHNSTON, CARMEN J. ALLEGRA
  • Monoclonal antibodies specific for human thymidylate synthase
    Patent number: 6221620
    Abstract: The present invention relates to monoclonal antibodies that are specific for the protein thymidylate synthase, and hybridomas producing these monoclonal antibodies. The invention further relates to methods of detection and diagnostic kits to test for the presence of thymidylate synthase. The invention also relates to the use of the monoclonal antibodies in determining the presence of colon carcinoma cells.
    Type: Grant
    Filed: April 24, 1991
    Date of Patent: April 24, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Patrick G. Johnston, Carmen J. Allegra, Bruce A. Chabner, Chi-Ming Liang
  • Methods for predicting the efficacy of a chemotherapeutic regimen for gastrointestinal cancers using antibodies specific for thymidylate synthase
    Patent number: 5998151
    Abstract: Methods for determining whether a chemotherapeutic treatment is appropriate for patients afflicted with gastrointestinal cancers, comprising;(a) obtaining a solid tumor tissue sample from the patient;(b) measuring a thymidylate synthase expression level in the tissue sample; and(c) comparing the thymidylate synthase expression level with a group of standard tumor tissue samples, the standards having known thymidylate synthase expression levels and known responses to the chemotherapeutic treatment, to determine if that chemotherapeutic treatment is appropriate for the patient.
    Type: Grant
    Filed: November 27, 1996
    Date of Patent: December 7, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Patrick G. Johnston, Carmen J. Allegra, Edwin R. Fisher