Patents by Inventor Carmen Méndez Fernández

Carmen Méndez Fernández has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aureolic acid derivatives, the method for preparation thereof and the uses
    Patent number: 8772253
    Abstract: Aureolic acid derivatives, process for obtaining them and uses thereof. This invention provides a bacterial strain that produces compound belonging to the family of aureolic acids useful in the treatment of cancer or nervous system diseases.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: July 8, 2014
    Assignee: Entrechem, S.L.
    Inventors: Luz Elena Núñez González, Nuria Menéndez Sánchez, Javier González Sabin, Francisco Moris Varas, Beatriz García Fernández, Maria Pérez Solares, Alfredo Fernández Braña, Maria del Carmen Méndez Fernández, José Antonio Salas Fernández
  • Glycosylated indolocarbazoles, method for obtaining same and uses thereof
    Patent number: 8598132
    Abstract: Glycosylated indolocarbazoles, method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and the production of rebeccamycin and staurosporine derivatives. The invention also relates to bacterial strains that are of use for the production of rebeccamycin and staurosporine derivatives. Lastly, the rebeccamycin and staurosporine derivatives described herein are applicable to the field of human health, specifically for manufacturing drugs that are of use in the treatment of tumour, neurological and inflammatory diseases.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: December 3, 2013
    Assignees: Universidad de Oviedo, Entrechem, S.L.
    Inventors: Aaroa Pérez Salas, César Sánchez Reillo, Alfredo Fernández Braña, Carmen Méndez Fernández, Jose Antonio Salas Fernández, Francisco Morís Varas
  • Glycosylate derivatives of mithramycin, method of preparation and uses thereof
    Patent number: 8426169
    Abstract: The present invention provides compounds characterized by the formula (I), where each of the substituent radicals is described in the specification. The invention also describes the use of said compounds in the treatment of various diseases, including: cancer or tumoral processes in general, Paget's disease, hypercalcaemia, hypercalciuria and neurological diseases (inter alia, Parkinson's, Alzheimer's, Huntington's).
    Type: Grant
    Filed: February 4, 2008
    Date of Patent: April 23, 2013
    Assignees: University of Kentucky Research Foundation, Universidad de Oviedo
    Inventors: Jürgen Rohr, Irfan Baig, José Antonio Salas Fernández, Alfredo Fernández Braña, Carmen Méndez Fernández, Mariá Pérez Solares
  • AUREOLIC ACID DERIVATIVES, THE METHOD FOR PREPARATION THEREOF AND THE USES THEREOF
    Publication number: 20120270823
    Abstract: Aureolic acid derivatives, process for obtaining them and uses thereof. This invention provides a bacterial strain that produces compound belonging to the family of aureolic acids useful in the treatment of cancer or nervous system diseases.
    Type: Application
    Filed: July 14, 2010
    Publication date: October 25, 2012
    Applicant: ENTRECHEM, S.L.
    Inventors: Luz Elena Núñez Gonzáez, Beatriz García Fernández, María Pérez Solares, Alfredo Fernández Braña, Nuria Menéndez Sánchez, Javier González Sabin, Francisco Morís Varas, María del Carmen Méndez Fernández, José Antonio Salas Fernández
  • Method of obtaining idolocarbazoles using biosynthetic rebeccamycin genes
    Patent number: 8207321
    Abstract: Method for production of indolocarbazoles by using rebeccamycin biosynthetic genes. The invention is based on utilization of rebeccamycin biosynthetic genes from Saccharothrix aerocolonigenes for production of indolocarbazoles in related microorganisms (Streptomyces spp.). Method includes the isolation of a DNA fragment from Saccharothrix aerocolonigenes ATCC39243 containing the rebeccamycin biosynthesis gene cluster and the expression of these genes in Streptomyces albus, achieving production of rebeccamycin and derivatives. The invention is suitable for use in the pharmaceutical field.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: June 26, 2012
    Assignee: Universidad De Oviedo
    Inventors: César Sánchez Reillo, Alfredo Fernandez Braña, José Antonio Salas Fernandez, Carmen Mendez Fernandez
  • OVIEDOMYCIN DERIVATIVES, METHOD FOR OBTAINING SAME AND USE THEREOF
    Publication number: 20110207705
    Abstract: Oviedomycin derivatives, method for obtaining same and use thereof. This invention relates to oviedomycin derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and to produce the oviedomycin derivatives. The invention further relates to bacterial strains that can be used to produce oviedomycin derivatives. Finally, said oviedomycin derivatives are applicable in the field of the human health, specifically to produce drugs for the treatment of tumour diseases.
    Type: Application
    Filed: March 26, 2009
    Publication date: August 25, 2011
    Applicant: UNIVERSIDAD DE OVIEDO
    Inventors: Carmen Méndez Fernández, Felipe Lombó Brugos, Alfredo A. Fernández Braña, José Antonio Salas Fernández
  • GLYCOSYLATED INDOLECARBAZOLES, METHOD FOR OBTAINING SAME AND USES THEREOF
    Publication number: 20110136753
    Abstract: Glycosylated indolocarbazoles, method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and the production of rebeccamycin and staurosporine derivatives. The invention also relates to bacterial strains that are of use for the production of rebeccamycin and staurosporine derivatives. Lastly, the rebeccamycin and staurosporine derivatives described herein are applicable to the field of human health, specifically for manufacturing drugs that are of use in the treatment of tumour, neurological and inflammatory diseases.
    Type: Application
    Filed: April 6, 2009
    Publication date: June 9, 2011
    Applicants: UNIVERSIDAD DE OVIEDO, ENTRECHEM S.L.
    Inventors: Aaroa Pêrez Salas, César Sánchez Reillo, Alfredo Fernández Braña, Carmen Méndez Fernández, Jose Antonio Salas Fernández, Francisco Morís Varas
  • GLYCOSYLATE DERIVATIVES OF MITHRAMYCIN, METHOD OF PREPARATION AND USES THEREOF
    Publication number: 20100086973
    Abstract: The present invention provides compounds characterized by the formula (I), where each of the substituent radicals is described in the specification. The invention also describes the use of said compounds in the treatment of various diseases, including: cancer or tumoral processes in general, Paget's disease, hypercalcaemia, hypercalciuria and neurological diseases (inter alia, Parkinson's, Alzheimer's, Huntington's).
    Type: Application
    Filed: February 4, 2008
    Publication date: April 8, 2010
    Applicant: University of Kentucky Research Foundation
    Inventors: Jürgen Rohr, Irfan Baig, José Antonio Salas Fernández, Alfredo Fernández Braña, Carmen Méndez Fernández, Mariá Pérez Solares
  • Genes Involved in the Biosynthesis of Thiocoraline and Heterologous Production of Same
    Publication number: 20090130675
    Abstract: The invention relates to genes involved in the biosynthesis of thiocoraline and to the heterologous production of same. According to the invention, the cluster of genes responsible for the biosynthesis of thiocoraline was identified and cloned. Said cluster of genes can be used in the heterologous production of thiocoraline which has an antitumor and antibacterial activity.
    Type: Application
    Filed: August 1, 2006
    Publication date: May 21, 2009
    Applicant: PHARMA MAR, S.A.
    Inventors: Angelina Ramos Castro, Alfredo Fernandez Brana, Felipe Lombo Brugos, Carmen Mendez Fernandez, Jose Antonio Salas Fernandez, Ana Velasco Iglesias, Carmen Schleissner Sanchez
  • Method of Obtaining Idolocarbazoles Using Biosynthetic Rebeccamycin Genes
    Publication number: 20080004326
    Abstract: Method for production of indolocarbazoles by using rebeccamycin biosynthetic genes. The invention is based on utilization of rebeccamycin biosynthetic genes from Saccharothrix aerocolonigenes for production of indolocarbazoles in related microorganisms (Streptomyces spp.). Method includes the isolation of a DNA fragment from Saccharothrix aerocolonigenes ATCC39243 containing the rebeccamycin biosynthesis gene cluster and the expression of these genes in Streptomyces albus, achieving production of rebeccamycin and derivatives. The invention is suitable for use in the pharmaceutical field.
    Type: Application
    Filed: October 17, 2002
    Publication date: January 3, 2008
    Inventors: Cesar Sanchez Reillo, Alfredo Fernandez Brana, Jose Antonio Salas Fernandez, Carmen Mendez Fernandez