Patents by Inventor Carmine Settembre

Carmine Settembre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF BONE GROWTH DISORDERS
    Publication number: 20200230207
    Abstract: The present invention relates to an activator of beclin 1-Vps 34 complex for use in the treatment and/or prevention of a bone growth disorder. The activator may be a polypeptide, a polynucleotide, a vector, a host cell or a small molecule. In particular the activator may be a Beclin 1 peptide or a fragment or a derivative thereof, a mTORC1 inhibitor or a BH3 mimetic. The present invention also relates to pharmaceutical composition comprising said activator.
    Type: Application
    Filed: September 28, 2016
    Publication date: July 23, 2020
    Inventors: Carmine SETTEMBRE, Laura CINQUE, Rosa BARTOLOMEO, Alberto AURICCHIO, Ivana TRAPANI, Elisabetta TORIELLO
  • TFEB variants and uses thereof
    Patent number: 9193755
    Abstract: The invention refers to TFEB related molecules, as variants, mutants, truncated proteins, chimeras etc. that are constitutively localized in the nucleus of a eukaryote cell. Such molecules have a therapeutic applicability in all of disorders that need of an induction of the cell authophagic/lysosomal system, as lysosomal storage disorders, neurodegenerative diseases, hepatic diseases, muscle diseases and metabolic diseases.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: November 24, 2015
    Assignee: FONDAZIONE TELETHON
    Inventors: Andrea Ballabio, Carmine Settembre, Diego Luis Medina Sanabria
  • TFEB VARIANTS AND USES THEREOF
    Publication number: 20150322124
    Abstract: The invention refers to TFEB related molecules, as variants, mutants, truncated proteins, chimeras etc. that are constitutively localized in the nucleus of a eukaryote cell. Such molecules have a therapeutic applicability in all of disorders that need of an induction of the cell authophagic/lysosomal system, as lysosomal storage disorders, neurodegenerative diseases, hepatic diseases, muscle diseases and metabolic diseases.
    Type: Application
    Filed: July 29, 2015
    Publication date: November 12, 2015
    Inventors: Andrea BALLABIO, Carmine SETTEMBRE, Diego Luis MEDINA SANABRIA
  • TFEB variants and uses thereof
    Patent number: 9127074
    Abstract: The invention refers to TFEB related molecules, as variants, mutants, truncated proteins, chimeras etc. that are constitutively localized in the nucleus of a eukaryote cell. Such molecules have a therapeutic applicability in all of disorders that need of an induction of the cell authophagic/lysosomal system, as lysosomal storage disorders, neurodegenerative diseases, hepatic diseases, muscle diseases and metabolic diseases.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: September 8, 2015
    Assignee: FONDAZIONE TELETHON
    Inventors: Andrea Ballabio, Carmine Settembre, Diego Luis Medina Sanabria
  • TFEB VARIANTS AND USES THEREOF
    Publication number: 20140038897
    Abstract: The invention refers to TFEB related molecules, as variants, mutants, truncated proteins, chimeras etc. that are constitutively localized in the nucleus of a eukaryote cell. Such molecules have a therapeutic applicability in all of disorders that need of an induction of the cell authophagic/lysosomal system, as lysosomal storage disorders, neurodegenerative diseases, hepatic diseases, muscle diseases and metabolic diseases.
    Type: Application
    Filed: March 7, 2012
    Publication date: February 6, 2014
    Applicant: FONDAZIONE TELETHON
    Inventors: Andrea Ballabio, Carmine Settembre, Diego Luis Medina Sanabria
  • TFEB PHOSPHORYLATION INHIBITORS AND USES THEREOF
    Publication number: 20140038920
    Abstract: The invention refers to TFEB phosphorylation inhibitors. Such molecules have a therapeutic applicability in all disorders that need induction of the cell authophagic/lysosomal system, such as lysosomal storage disorders, neurodegenerative diseases, hepatic diseases, muscle diseases and metabolic diseases.
    Type: Application
    Filed: March 7, 2012
    Publication date: February 6, 2014
    Applicant: FONDAZIONE TELETHON
    Inventors: Andrea Ballabio, Carmine Settembre, Diego Luis Medina Sanabria