Abstract: The present disclosure relates to certain molecules, pharmaceutical compositions containing them, and methods of using them to treat viral infections.

Abstract: The present disclosure relates to certain molecules, pharmaceutical compositions containing them, and methods of using them to treat viral infections.

Abstract: Provided herein are zintrodes to measure intracranial free zinc levels in an individual or free zinc levels in solution. The zintrodes and multitrodes comprise a zinc chelator and a fluorophore or may comprise only a zinc-chelating fluorophore, an optical fiber having an optical tip, and a means of entrapping the zinc chelator and the fluorophore or the zinc-chelating fluorophore proximate to the optical tip within the zintrode. The zintrode may comprise a multitrode. Also provided are methods of real-time buffering of zinc ion levels in vivo in brain tissue to treat an excitotoxic neural injury using the zintrodes and multitrodes described herein. Additionally, provided herein are a system and method to measure pZn in solution.

Abstract: The invention described in detail herein relates to the detection, determination, and quantitation of certain ions and small molecules in solution. The invention specifically relates to improvements in the area of photoluminescent sensors for use in a detection scheme involving the alteration of a photoluminescent label or moiety attached to or associated with an analyte binding macromolecule. One may use the changes in photoluminescence lifetime, changes in ratios of photoluminescence intensity or changes in photoluminescence polarization (anisotropy) to determine the analyte. The photoluminescence change measured correlates to the concentration of the ion or molecule in solution.