Patents by Inventor Carol A. Fulcher

Carol A. Fulcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Factor VIII coagulant polypeptides and monoclonal antibodies to them
    Patent number: 5747337
    Abstract: Polypeptides have been discovered which exhibit high specific VIII:C coagulant activity. Monoclonal antibodies to the polypeptides are also disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: May 5, 1998
    Assignee: The Scripps Research Institute
    Inventors: Theodore S. Zimmerman, Carol A. Fulcher
  • Factor VIII binding domain of von Willebrand factor
    Patent number: 5597711
    Abstract: Peptides which inhibit the binding of yon Willebrand Factor to Factor VIII. Monoclonal antibodies capable of specifically binding to the region of von Willebrand Factor containing the Factor VIII binding domain. Improved methods of preparing Factor VIII.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: January 28, 1997
    Assignee: The Scripps Research Institute
    Inventors: Theodore S. Zimmerman, Paul A. Foster, Carol A. Fulcher
  • Factor VIII coagulant polypeptides: method of making
    Patent number: 5362854
    Abstract: Fragments of Factor VIII:C polypeptide have been discovered which exhibit highly specific factor VIII activity. Monoclonal antibodies to the polypeptide fragments and methods for the isolation and purification of said fragments are also disclosed.
    Type: Grant
    Filed: February 24, 1993
    Date of Patent: November 8, 1994
    Assignee: Scripps Clinic & Research Foundation
    Inventors: Theodore S. Zimmerman, Carol A. Fulcher
  • Factor VIII binding domain of von Willebrand Factor
    Patent number: 5260274
    Abstract: Peptides which inhibit the binding of von Willebrand Factor to Factor VIII. Monoclonal antibodies capable of specifically binding to the region of von Willebrand Factor containing the Factor VIII binding domain. Improved methods of preparing Factor VIII.
    Type: Grant
    Filed: July 3, 1991
    Date of Patent: November 9, 1993
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Theodore S. Zimmerman, Paul A. Foster, Carol A. Fulcher
  • Factor VIII coagulant polypeptides
    Patent number: 5214033
    Abstract: Fragments of the factor VIII:C polypeptide have been discovered which exhibit highly specific factor VIII activity. Monoclonal antibodies to the polypeptide fragments and methods for the isolation and purification of said fragments are also disclosed.
    Type: Grant
    Filed: July 15, 1991
    Date of Patent: May 25, 1993
    Assignee: Scripps Clinic & Research Foundation
    Inventors: Theodore S. Zimmerman, Carol A. Fulcher
  • Recombinant Factor VIIIC fragments
    Patent number: 5149637
    Abstract: New fragments of the Factor VIII procoagulant protein (Factor VIIIC) are disclosed. These fragments have an Mr value of 88,000 d or 49,000 d or extend from amino acid residues 1974 to 2332 or 2052 to 2332. These fragments have use in the treatment of patients who have developed antibodies which inhibit Factor VIII.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: September 22, 1992
    Assignees: Scripps Clinic & Research Foundation, Rorer Biotechnology Inc.
    Inventors: Dorothea H. Scandella, William N. Drohan, Theodore S. Zimmerman, Carol A. Fulcher
  • Factor VIII coagulant polypeptides and monoclonal antibodies to them
    Patent number: 5101016
    Abstract: Polypeptides have been discovered which exhibit high specific VIII:C coagulant activity. Monoclonal antibodies to the polypeptides are also disclosed.
    Type: Grant
    Filed: October 10, 1990
    Date of Patent: March 31, 1992
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Theodore S. Zimmerman, Carol A. Fulcher
  • Protein fragments containing Factor VIII binding domain of von Willebrand Factor
    Patent number: 5043429
    Abstract: Peptides which inhibit the binding of von Willebrand Factor to Factor VIII. Monoclonal antibodies capable of specifically binding to the region of von Willebrand Factor containing the Factor VIII binding domain. Improved methods of preparing Factor VIII.
    Type: Grant
    Filed: May 1, 1987
    Date of Patent: August 27, 1991
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Theodore S. Zimmerman, Paul A. Foster, Carol A. Fulcher
  • Recombinant factor VIIIC derived fragments
    Patent number: 4980456
    Abstract: New fragments of the Factor VIII procoagulant protein (Factor VIIIC) are disclosed. These fragments have an Mr value of 88,000 d or 49,000 d or extend from amino acid residues 1974 to 2332 or 2052 to 2332. These fragments have use in the treatment of patients who have developed antibodies which inhibit Factor VIII.
    Type: Grant
    Filed: April 6, 1987
    Date of Patent: December 25, 1990
    Assignees: Scripps Clinic and Research Foundation, Rorer Biotechnology Inc.
    Inventors: Dorothea H. Scandella, William N. Drohan, Theodore S. Zimmerman, Carol A. Fulcher
  • Factor VIII coagulant polypeptides
    Patent number: 4886876
    Abstract: Active factor VIII:C coagulant polypeptides identified by partial amino acid sequences are disclosed.
    Type: Grant
    Filed: April 13, 1987
    Date of Patent: December 12, 1989
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Theodore S. Zimmerman, Carol A. Fulcher
  • Factor VIII coagulant polypeptides and monoclonal antibodies tof them
    Patent number: 4857635
    Abstract: Polypeptides have been discovered which exhibit high specific VIII:C coagulant activity. Monoclonal antibodies to the polypeptides are also disclosed.
    Type: Grant
    Filed: September 20, 1985
    Date of Patent: August 15, 1989
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Theodore S. Zimmerman, Carol A. Fulcher
  • Flouroplastic immunoaffinity columns for purification of blood proteins
    Patent number: 4831118
    Abstract: The present invention is a protein purification column comprising an organic substrate matrix having low reactivity to proteins, said matrix being capable of maintaining monoclonal antibodies attached thereto in an external configuration and preventing interaction with the protein to be bound to the antibody, and a monoclonal antibody attached to the substrate, the monoclonal antibody having a specific affinity for the protein to be isolated.The present invention also is a method for isolating and purifying specific protein from a solution, wherein1. Protein-specific monoclonal antibody is attached to the organic substrate matrix described above to form an antibody-substrate conjugate; and2. Protein to be isolated, in an appropriate buffer solution, is contacted with the antibody-substrate conjugate.An appropriate buffer may be applied to remove non-antibody bound contaminants, followed by an appropriate eluting agent to remove the protein from the monoclonal antibody.
    Type: Grant
    Filed: August 7, 1987
    Date of Patent: May 16, 1989
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Theodore S. Zimmerman, Carol A. Fulcher
  • Treatment of factor VIII inhibitors
    Patent number: 4769336
    Abstract: Fragments of human Factor VIII:C which bind to antibody inhibitors of Factor VIII in patients afflicted with such inhibitors are disclosed. The method of treating Factor VIII inhibitors, by administering one or more of these fragments, is also disclosed.
    Type: Grant
    Filed: February 12, 1987
    Date of Patent: September 6, 1988
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Theodore S. Zimmerman, Carol A. Fulcher
  • New factor VIII coagulant polypeptides
    Patent number: 4657894
    Abstract: Active factor VIII:C coagulant polypeptides identified by partial amino acid sequences are disclosed.
    Type: Grant
    Filed: November 21, 1984
    Date of Patent: April 14, 1987
    Assignee: Scripps Clinic & Research Foundation
    Inventors: Theodore S. Zimmerman, Carol A. Fulcher
  • Treatment of Factor VIII inhibitors
    Patent number: 4649132
    Abstract: Fragments of human Factor VIII:C which bind to antibody inhibitors of Factor VIII in patients afflicted with such inhibitors are disclosed. The method of treating Factor VIII inhibitors, by administering one or more of these fragments, is also disclosed.
    Type: Grant
    Filed: May 24, 1985
    Date of Patent: March 10, 1987
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Theodore S. Zimmerman, Carol A. Fulcher
  • Ultrapurification of factor VIII using monoclonal antibodies
    Patent number: 4361509
    Abstract: A method of preparing high purity procoagulant protein comprising the steps of (a) adsorbing a VIII:C/VIII:RP complex from a plasma or commercial concentrate source of factor VIII onto agarose beads bound to a monoclonal antibody specific to VIII:RP, (b) eluting VIII:C with a salt solution, (c) adsorbing the eluted VIII:C on an animohexyl agarose column and eluting the VIII:C with a salt solution.
    Type: Grant
    Filed: December 14, 1981
    Date of Patent: November 30, 1982
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Theodore S. Zimmerman, Carol A. Fulcher
  • Ultrapurification of factor VIII using monoclonal antibodies
    Patent number: RE32011
    Type: Grant
    Filed: December 21, 1983
    Date of Patent: October 22, 1985
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Theodore S. Zimmerman, Carol A. Fulcher