Abstract: The present invention is a self-injection pen. The self-injection pen has a needle, a medication cartridge, and a pen body. The needle and the medication cartridge are standard commercially available components that are suitable for injecting a liquid medication into the subcutaneous tissue layer of a human or animal body. The medication cartridge has a dose adjustor, and the pen body has an outer casing, a dose adjustment dial and an injector button. The needle is secured to the medication cartridge and allows a liquid medication to flow from the medication cartridge into the body of the user. The dose adjustor controls the amount of liquid medication being administered from the medication cartridge.

Abstract: The present invention encompasses ophthalmic compositions that may be used for various conditions of the eye, and particularly, conditions of the cornea. Also encompassed are methods that utilise these compositions and kits that include these compositions.

Abstract: A soft baked, shelf stable brownie including a high amount of hydrolyzed collagen that achieves an indulgent texture and flavor, yet retains a soft, moist eating experience over an extended shelf life is described. The brownie includes pantry friendly ingredients to form a matrix that includes collagen, chia seed, a flour content that includes at least a portion that is gluten-free, fiber and/or sugar syrup, and fat to achieve an indulgent eating experience. Methods of making a soft baked brownie are also disclosed.

Abstract: A nonobstructive protective housing for a fire sprinkler head has a first case half and a second case half with apertures formed in the case halves. The second case half is hingedly coupled to the first case half. The first case half and the second case half are movable between an open position and a closed position. A method of non-obstructively protecting a fire sprinkler head with the nonobstructive protective housing includes fastening the nonobstructive protective housing around the fire sprinkler head such that the apertures accommodate a flow of water from the fire sprinkler head.

Abstract: A method for ceramming a glass article to a glass-ceramic includes placing a glass article into a heating apparatus, and heating the glass article to a first hold temperature at a first predetermined heating rate. The glass article is held at the first hold temperature for a first predetermined duration. The viscosity of the glass article is maintained within log viscosity ±1.0 poise during the first predetermined duration. The glass article is then heated from the first hold temperature to a second hold temperature at a second predetermined heating rate. The glass article is held at the second hold temperature for a second duration. A density of the glass article is monitored from the heating of the glass article from the first hold temperature through the second duration, and the second duration is ended when an absolute value of a density rate of change of the glass article is less than or equal to 0.10 (g/cm3)/min.

Abstract: A glass-ceramic article comprises: a center-volume composition comprising (on an oxide basis): 55-75 mol % SiO2; 0.2-10 mol % Al2O3; 0-5 mol % B2O3; 15-30 mol % Li2O; 0-2 mol % Na2O; 0-2 mol % K2O; 0-5 mol % MgO; 0-2 mol % ZnO; 0.2-3.0 mol % P2O5; 0.1-10 mol % ZrO2; 0-4 mol % TiO2; and 0-1.0 mol % SnO2. Lithium disilicate and either ?-spodumene or ?-quartz are the two predominant crystalline phases (by weight) of the glass-ceramic article. The glass-ceramic article further comprises tetragonal ZrO2 as a crystalline phase. The composition of the glass-ceramic article from a primary surface into a thickness of the glass-ceramic article can comprise over 10 mol % Na2O (on an oxide basis), with the mole percentage of Na2O decreasing from the primary surface towards the center-volume. The glass-ceramic article exhibits a ring-on-ring load-to-failure of at least 120 kgf, when the thickness of the glass-ceramic article is 0.3 mm to 2.0 mm.

Abstract: A method of minimizing the formation of a rhodium-platinum defect in a glass or glass ceramic material or in the melt thereof is provided. The method includes providing a vessel made of a platinum-rhodium alloy for use in a manufacturing process for obtaining the material, and an interface between the vessel and the melt is present. The method can include providing sufficient partial pressures of hydrogen outside and inside the vessel for controlling the partial pressure of oxygen in a region of the melt adjacent to the interface. A method of minimizing the formation of, or counteracting the impact of, a localized thermal, electrical, or composition cell in the melt during a manufacturing process is also provided. The method can include adding a multivalent compound to the melt, adding a mixer to the finer tube, adding a mixing step to the manufacturing process, or amplifying the mixing.

Abstract: A system and method for the real-time management of a device, and more particularly to the establishment and enforcement of policies or rules associated with the feature or functions that may be performed with the device, such as making and receiving calls, exchanging data, playing games and music, sending and receiving email, accessing web sites, and paying for goods and services. If a child or employee is using the device, there may be a need to regulate how that device can be used and to determine who will pay for what goods or services. In addition to providing all of the features associated with a device, service providers need to be able to establish and enforce rules (policies) regulating how and when that device can be used and who will pay for a good or service requested by the user of the device.

Abstract: A method and system provide estimated tax refund data to a user of a tax return preparation system throughout personalized tax return preparation interview. The method and system receive current user tax related data associated with the user, retrieve tax rules data, and gather historical tax related data associated with historical users of the tax return preparation system. The method and system further generate probabilistic inference data including inferences about tax related characteristics of the user based on the historical tax related data and the tax rules data. The method and system provide estimated tax refund data to the user based on the probabilistic inference data.

Abstract: A glass-ceramic article comprises: a center-volume composition comprising (on an oxide basis): 55-75 mol % SiO2; 0.2-10 mol % Al2O3; 0-5 mol % B2O3; 15-30 mol % Li2O; 0-2 mol % Na2O; 0-2 mol % K2O; 0-5 mol % MgO; 0-2 mol % ZnO; 0.2-3.0 mol % P2O5; 0.1-10 mol % ZrO2; 0-4 mol % TiO2; and 0-1.0 mol % SnO2. Lithium disilicate and either ?-spodumene or ?-quartz are the two predominant crystalline phases (by weight) of the glass-ceramic article. The glass-ceramic article further comprises tetragonal ZrO2 as a crystalline phase. The composition of the glass-ceramic article from a primary surface into a thickness of the glass-ceramic article can comprise over 10 mol % Na2O (on an oxide basis), with the mole percentage of Na2O decreasing from the primary surface towards the center-volume. The glass-ceramic article exhibits a ring-on-ring load-to-failure of at least 120 kgf, when the thickness of the glass-ceramic article is 0.3 mm to 2.0 mm.

Abstract: A glass ceramic article including a lithium disilicate crystalline phase, a petalite crystalline phased, and a residual glass phase. The glass ceramic article has a warp (?m)<(3.65×10?9/?m×diagonal2) where diagonal is a diagonal measurement of the glass ceramic article in ?m, a stress of less than 30 nm of retardation per mm of glass ceramic article thickness, a haze (%)<0.0994t+0.12 where t is the thickness of the glass ceramic article in mm, and an optical transmission (%)>0.91×10(2-0.03t) of electromagnetic radiation wavelengths from 450 nm to 800 nm, where t is the thickness of the glass ceramic article in mm.

Abstract: A system and method for the real-time management of a device, and more particularly to the establishment and enforcement of policies or rules associated with the feature or functions that may be performed with the device, such as making and receiving calls, exchanging data, playing games and music, sending and receiving email, accessing web sites, and paying for goods and services. If a child or employee is using the device, there may be a need to regulate how that device can be used and to determine who will pay for what goods or services. In addition to providing all of the features associated with a device, service providers need to be able to establish and enforce rules (policies) regulating how and when that device can be used and who will pay for a good or service requested by the user of the device.

Abstract: A glass-ceramic article having greater than or equal to 65.00 wt. % and less than or equal to 80.00 wt. % SiO2, greater than 4.00 wt. % and less than or equal to 12.00 wt. % Al2O3, greater than or equal to 0.10 wt. % and less than or equal to 3.5 wt. % P2O5, greater than or equal to 8.00 wt. % and less than or equal to 17.00 wt. % Li2O, greater than or equal to 4.00 wt. % and less than or equal to 15.00 wt. % ZrO2, and greater than or equal to 0.05 wt. % and less than or equal to 4.00 wt. % CaO.

Abstract: A glass ceramic article including a lithium disilicate crystalline phase, a petalite crystalline phased, and a residual glass phase. The glass ceramic article has a warp (?m)<(3.65×10?9/?m×diagonal2) where diagonal is a diagonal measurement of the glass ceramic article in ?m, a stress of less than 30 nm of retardation per mm of glass ceramic article thickness, a haze (%)<0.0994t+0.12 where t is the thickness of the glass ceramic article in mm, and an optical transmission (%)>0.91×10(2?0.03t) of electromagnetic radiation wavelengths from 450 nm to 800 nm, where t is the thickness of the glass ceramic article in mm.

Abstract: Exclusion devices for anatomical structures, and related instruments and related methods, are disclosed. An application instrument for an exclusion device may include an end effector including a head configured to be disposed distally on a shaft, a stationary jaw fixedly disposed on the head and configured to releasably couple to a first clamping portion of an exclusion device, the exclusion device being biased in a closing direction, and a movable jaw movably disposed on the head and configured to releasably couple to a second clamping portion of the exclusion device. The movable jaw may be movable relative to the stationary jaw to reconfigure the exclusion device from a closed configuration to an open configuration. The movable jaw may be oriented generally parallel to the stationary jaw when the exclusion device is in the open configuration and the closed configuration.

Abstract: Exclusion devices for anatomical structures, and related instruments and related methods, are disclosed. An exclusion device for an anatomical structure may include a first beam, a second beam, and/or at least one spring operatively coupled to the first beam and the second beam to exert a closing force on the first beam and the second beam and bias the first beam and the second beam in a closing direction. The spring may be operatively coupled to the first beam by a crimp connection.

Abstract: Exclusion devices for anatomical structures, and related instruments and related methods, are disclosed. An exclusion device may include a first clamping portion, a second clamping portion opposing the first clamping portion, and/or a biocompatible fabric cover at least partially sheathing the first clamping portion and/or the second clamping portion. The cover may be generally tubular and/or may define a relaxed circumference when the first clamping portion and the second clamping portion are in a closed configuration. At least a portion of the cover may be configured to stretch to a stretched circumference of about 2× to about 3× the relaxed circumference when the first clamping portion and the second clamping portion are reconfigured from the closed configuration to an open configuration.

Abstract: Exclusion devices for anatomical structures, and related instruments and related methods, are disclosed. An exclusion device for an anatomical structure may include a first beam, a second beam, and/or a first spring operatively coupled to the first beam and the second beam to exert a closing force on the first beam and the second beam. The first spring may be generally U-shaped and/or may include a first end portion and a second end portion generally opposite a connecting portion.

Abstract: A computer-implemented system and method for predicting rule-based compliance scenarios to implement rule-based topic determinations. A server computing device generates a compliance scenario prediction model by training a machine learning model for a topic with historical user data and cohort labels created by analyzing the scenarios in a completeness graph to predict a set of scenario cohorts that constitute a set of most probable compliance scenarios. The server computing device executes the scenario prediction model to process a user profile including data features associated with the topic to predict a scenario cohort and a compliance scenario corresponding to the predicted cohort for the user. The server computing device automatically infers one or more personalized responses to at least one question of the respective decision node based on the predicted compliance scenario.

Abstract: This invention relates to kits including novel oral food challenge meal formulations. In particular, the invention also relates to kits including novel oral food challenge meal formulations, wherein the placebo dose formulation is indistinguishable from non-placebo dose formulations.